A modified anaesthetic induction chamber for rats

Gwynne, B. J.; Wallace, Julian M.

doi:10.1258/002367792780740620

Cited by 6 publications

(2 citation statements)

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“…Induction chambers can be purchased or made (Gwynne & Wallace, 1992) from acrylic or other clear materials. Standard induction chambers have a fresh gas inlet and an outlet for exhaled and waste gases.…”

Section: Induction Chambers and Anesthetic Deliverymentioning

confidence: 99%

Mouse and Rat Anesthesia and Analgesia

Oh,

Narver

2024

Current Protocols

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Anesthesia and analgesia play pivotal roles in ethically and humanely using animal models in research, especially concerning mice and rats. These rodent species, extensively utilized in scientific investigations due to their genetic resemblance to humans, serve as invaluable tools for studying diseases and testing treatments. Proper anesthesia and analgesia not only prioritize animal welfare but also heighten experimental validity by minimizing stress‐induced physiological responses. Recent years have seen remarkable advancements in anesthesia for mice and rats. The focus has shifted away from the ‘one size fits all’ toward tailoring anesthesia protocols, considering factors like age, strain, and the nature of the experimental procedure. The use of inhalation agents such as isoflurane and sevoflurane is often preferred due to their rapid induction and recovery characteristics, allowing precise control over anesthesia depth. However, refinements in injectable anesthetic agents also provide researchers the flexibility to select suitable agents based on study requirements. Additionally, progress in analgesic techniques has led to effective pain management strategies for these rodents. Common analgesics such as nonsteroidal anti‐inflammatory drugs (NSAIDs), opioids, and local anesthetics are administered to alleviate pain and discomfort. However, standard practice also involves continuous monitoring of animals' behavior and physiological parameters, ensuring timely adjustments in analgesic regimens for optimal pain relief without compromising experimental outcomes. By integrating tailored anesthesia and analgesia protocols into the experimental design, researchers uphold high animal welfare standards while obtaining reliable scientific data. This contributes significantly to advancing medical knowledge and therapeutic interventions with reproducible results. Published 2024. This article is a U.S. Government work and is in the public domain in the USA. Current Protocols published by Wiley Periodicals LLC.Basic Protocol 1: Injectable anesthesia for mouse and ratBasic Protocol 2: Inhalant anesthesia using isoflurane for mouse and ratBasic Protocol 3: Analgesia for mice and rats

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Section: Induction Chambers and Anesthetic Deliverymentioning

confidence: 99%

Mouse and Rat Anesthesia and Analgesia

Oh,

Narver

2024

Current Protocols

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“…Induction chambers can be purchased or made (Gwynne and Wallace, 1992) from acrylic or other clear materials. Standard induction chambers have a fresh gas inlet and an outlet for exhaled and waste gases.…”

Section: Induction Chambersmentioning

confidence: 99%

Mouse and Rat Anesthesia and Analgesia

Davis

2001

CP Neuroscience

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Many animal models used in neuroscience research must be surgically created and/or anesthetized for imaging studies. The purpose of this unit is to review the advantages and disadvantages of various anesthetic and analgesic agents in rodents; to discuss state‐of‐the‐art methods for monitoring anesthesia; and to provide tips for troubleshooting problems with anesthesia. Curr. Protoc. Neurosci. 42:A.4B.1‐A.4B.21. © 2008 by John Wiley & Sons, Inc.

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Mouse and Rat Anesthesia and Analgesia

Davis

2008

CP Neuroscience

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A modified anaesthetic induction chamber for rats

Cited by 6 publications

References 1 publication

Mouse and Rat Anesthesia and Analgesia

Mouse and Rat Anesthesia and Analgesia

Mouse and Rat Anesthesia and Analgesia

Mouse and Rat Anesthesia and Analgesia

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