“…Of potential interest, however, is an intercuff technique for IV RA that has been developed for use in knee surgery in an effort to produce better localization and reduce overall dosing requirements. 249,250 Opioids (other than meperidine, 30 mg or more) are generally considered not to be beneficial when given via the IV regional technique 251 ; systemic side effects of meperidine are manifested at the 30-mg threshold. Tramadol, 100 mg, administered as IV RA with lidocaine is associated with a selflimited rash below the tourniquet and does not necessarily confer an analgesic benefit.…”