A Moderate-Intensity Static Magnetic Field Enhances Repair of Cartilage Damage in Rabbits

Super-paramagnetic responsive nanofibrous scaffolds under static magnetic field enhance osteogenesis for bone repair in vivo

“…For instances, several groups reported that weak magnetic or pulse electromagnetic fields of Gauss order are one effective stimuli that promoted bone fracture healing, spinal fusion, bone ingrowths into ceramics in animal models121314151617181920. Strong static magnetic field of 5–10 T was also reported to have the potency of regulating the orientation of matrix proteins and cells in vitro and in vivo 212223242526272829303132.…”

Magnetic field application or mechanical stimulation via magnetic microparticles does not enhance chondrogenesis in mesenchymal stem cell sheets

“…A pulsed electromagnetic magnetic field (1 T; 30 single pulses each 5 ms in duration (200 Hz) with 5 s in between pulses) elevated chondrogenic gene expression and GAG/DNA of human adipose-derived stem cells in monolayer and pellet cultures in growth medium to similar levels as cells grown in chondrogenic medium 14 . In vivo, an estimated 8 mT static field induced healing of osteochondral defects in rabbits compared to sham-operated groups 15 and a 1.6 mT pulsed electromagnetic field (4.5 ms duration (222 mHz) single pulse repeated at 15 bursts/s, 8 hr/day) accelerated chondrogenesis during endochondral ossification 28 . These few studies illustrate that magnetic fields by themselves may influence chondrogenesis in specific circumstances, although the mechanisms behind its actions are poorly understood 5, 24 .…”

“…While application of a magnetic field without the incorporation of a magnetically responsive material into tissue engineered constructs has been reported to enhance chondrogenesis 13–15 , mechanostimulation via magnetic particles has not been evaluated on its ability to improve cartilage formation. In this work, the ability of static and variable magnetic fields to enhance chondrogenesis of scaffold-free human mesenchymal stem cell (hMSC) sheets undergoing chondrogenesis 16 without and with incorporated magnetic particles, which exert forces on cells and/or surrounding ECM in response to the gradients in the magnetic field, was investigated in a custom-made magnetic field bioreactor.…”

The effects of EMF (ELECTROMAGNETIC FIELDS) on the Bone and Cartilage Tissue

“…Moderate-intensity SMF have also been shown to promote bone formation and prevent decrease in bone mineral density in an ischemic rat model [9]. Decreasing in lamation and edema are among the other effects of SMF [9].…”

“…Published: May 1, 2017 055 0,6 T static magnetic ield increased metabolic activity in human cartilage tissue, whereas moderate intensity SMF induced cell proliferation, and high intensity SMF (3T) reduced human chondrocyte cell proliferation and induced cell apoptosis [9].…”