A model system for evaluating the role of dietary fiber in chemical carcinogenesis

Clinton, Steven K.; Truex, C. R.; Visek, Willard J.

doi:10.1016/0006-2952(78)90128-4

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Various dietary fibers are known to bind biliary steroids in vitro [25]. Clinton et al [26] found that wheat bran decreased exposure of the intestinal epithelium to the carcinogen benzo(cr)pyrene (BP) in BP-treated rats. A highfiber diet appears to decrease the mutagenicity of human feces as evaluated by.…”

Section: Introductionmentioning

confidence: 99%

“…In dietary studies in which rats were treated with 1,2-dimethylhydrazine (DMH) or its metabolites, both plant oil and animal fat have significantly increased the incidence of large bowel tumors [20][21][22][23][24][25][26][27][28][29][30][31][32][33] as has a high-protein diet in one study [34] (but not in another [35]). Fibers such as wheat bran [36][37][38][39][40][41] or cellulose [37,42,43] have decreased large bowel carcinogenesis in some cases but not in others [41,[44][45][46].…”

Section: Introductionmentioning

confidence: 99%

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Effects of wheat, rice, corn, and soybean bran on 1,2‐dimethylhydrazine‐induced large bowel tumorigenesis in F344 rats

Barnes

Clapp

Scott

et al. 1983

Nutrition and Cancer

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This study was designed to determine the relative effects of four dietary brans on large bowel tumorigenesis in rats treated with 1,2-dimethylhydrazine (DMH). Four-week-old F344 rats were fed a 20% bran (either wheat, rice, corn, or soybean) semisynthetic diet or a no-fiber-added control diet for life. All rats except for one control diet for life. All rats except for one control group were infected with DMH (2SC doses; approximately 150 mg/kg body weight) at 8 and 10 weeks of age. Two additional groups were fed the control diet and then at 4 and 18 weeks, respectively, after the second DMH dose, were fed the wheat bran diet. All surviving rats were killed 9 months following the first DMH dose. Survival was increased in all groups receiving bran diets. Large bowel tumor incidences in the DMH group were as follows: control, 95%; wheat, 75%; rice 86%; corn, 100%; soybean, 84%; wheat after 4 weeks, 62% (lower than control group, p less than 0.05); wheat after 18 weeks, 84%. All but one of the DMH groups had approximately two tumors/tumor-positive rat; the corn group had four. The effect of bran on large bowel carcinogenesis appears to depend both on the source of bran and when it is fed in relation to tumor initiation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of wheat, rice, corn, and soybean bran on 1,2‐dimethylhydrazine‐induced large bowel tumorigenesis in F344 rats

Barnes

Clapp

Scott

et al. 1983

Nutrition and Cancer

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Epidemiology of Colon Cancer: Fiber, Fats, Fallacies, and Facts

Modan

Lubin

1980

Medical Aspects of Dietary Fiber

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Effects of Dietary Fiber on Gastrointestinal Transit Time, Fecal Properties and Fat Absorption in Rats.

Munakata¹,

Iwane²,

Todate³

et al. 1995

Tohoku J. Exp. Med.

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The gastrointestinal transit time of food was determined by x-ray fluoroscopy using barium sulfate in rats fed with diets of various dietary fiber contents, and the effects of dietary fiber on the transit time, properties of feces, and fat absorption were examined. In 4-and 16-month-old rats fed with the diet for 3 and 15 month, respectively, the transit time of the cecum and colon in those receiving 20 and 40% wheat bran diets was shortened compared with that in the 0% group. The fecal pellet number and volume increased as the wheat bran content of the diet increased. In another experiments, the daily total fat excretion was found to be the greatest in rats receiving 15% pectin diet, followed by rats receiving 15% cellulose and non-fiber diets, respectively. These results suggest that shortening of the transit time through the cecum and colon with increase of fecal volume and suppression of fat absorption all participate in the mechanism of the inhibitory action of wheat bran on carcinogenesis and on the development of diverticulum of the large intestine, dietary fiber; wheat bran; transit timeThe effects of dietary fiber (DF) on gastrointestinal function, which have been described in many reports, include its action in shortening the gastrointestinal transit time of food, especially large intestine transit time, which has received attention as a major factor for the development of colonic carcinomas, and also for the development of diverticulum in the large intestine (Burkitt 1971;Burkitt et al. 1972). In the present study, we measured the transit time of food through each of the esophagus, stomach, and small and large intestine in rats fed with wheat bran by x-ray fluoroscopy using barium sulfate to examine the effects of dosage and administration period of wheat bran on the transit time. The changes in fecal properties induced by wheat bran administration and the effects of pectin

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A model system for evaluating the role of dietary fiber in chemical carcinogenesis

Cited by 3 publications

References 8 publications

Effects of wheat, rice, corn, and soybean bran on 1,2‐dimethylhydrazine‐induced large bowel tumorigenesis in F344 rats

Effects of wheat, rice, corn, and soybean bran on 1,2‐dimethylhydrazine‐induced large bowel tumorigenesis in F344 rats

Epidemiology of Colon Cancer: Fiber, Fats, Fallacies, and Facts

Effects of Dietary Fiber on Gastrointestinal Transit Time, Fecal Properties and Fat Absorption in Rats.

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