A model of heart rate changes to detect seizures in severe epilepsy

Elmpt, Wouter J. C. van; Nijsen, Tamara M.E.; Griep, P.A.M.; Arends, Johan

doi:10.1016/j.seizure.2006.03.005

Cited by 103 publications

(115 citation statements)

References 14 publications

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“…16 Severe tachycardia, a common feature of seizures in human patients, correlates with neuronal discharges and is a sensitive method for early detection of seizures in newborns and adult patients. [20][21][22][23][24] In newborn piglets, we observed a robust increase in HR concomitant with vasodilation of pial arterioles for the duration of the ictal episode. 7-10 Therefore, we compared the bicuculline-induced dynamics of HR as a reliable indicator of seizure activity in control and CORM-A1-treated piglets (Figure 3).…”

Section: Acute Effects Of Enteral Corm-a1 In Systemic and Cerebral CImentioning

confidence: 68%

“…8 Alternatively, one may hypothesize that CO-derived CORM-A1 has anticonvulsant effects. However, CORM-A1 did not affect the dynamics of ictal tachycardia, a reliable and sensitive indicator of status epilepticus in patients, [20][21][22][23][24] of the EEG suggested that CO has proconvulsant, rather than anticonvulsant action. 16 Importantly, CORM-A1 (2 mg/kg), administered via enteral or parenteral routes, provides a safe and effective pharmacological option for prevention of oxidative stress-induced cerebral vascular disease.…”

Section: Discussionmentioning

confidence: 92%

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Enteral Supplements of a Carbon Monoxide Donor CORM-A1 Protect against Cerebrovascular Dysfunction Caused by Neonatal Seizures

Liu

Fedinec

Leffler

et al. 2014

J Cereb Blood Flow Metab

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Cerebral blood flow dysregulation caused by oxidative stress contributes to adverse neurologic outcome of seizures. A carbon monoxide (CO) donor CORM-A1 has antioxidant and cytoprotective properties. We investigated whether enteral supplements of CORM-A1 can improve cerebrovascular outcome of bicuculline-induced seizures in newborn piglets. CORM-A1 (2 mg/kg) was given to piglets via an oral gastric tube 10 minutes before or 20 minutes after seizure onset. Enteral CORM-A1 elevated CO in periarachnoid cerebrospinal fluid and produced a dilation of pial arterioles. Postictal cerebral vascular responses to endothelium-, astrocyte-, and vascular smooth muscle-dependent vasodilators were tested 48 hours after seizures by intravital microscopy. The postictal responses of pial arterioles to bradykinin, glutamate, the AMPA receptor agonist quisqualic acid, ADP, and heme were greatly reduced, suggesting that seizures cause injury to endothelial and astrocyte components of the neurovascular unit. In contrast, in the two groups of piglets receiving enteral CORM-A1, the postictal cerebral vascular responsiveness to these dilators was improved. Overall, enteral supplements of CORM-A1 before or during seizures offer a novel effective therapeutic option to deliver cytoprotective mediator CO to the brain, reduce injury to endothelial and astrocyte components of cerebral blood flow regulation and to improve the cerebrovascular outcome of neonatal seizures.

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Section: Acute Effects Of Enteral Corm-a1 In Systemic and Cerebral CImentioning

confidence: 68%

Section: Discussionmentioning

confidence: 92%

Enteral Supplements of a Carbon Monoxide Donor CORM-A1 Protect against Cerebrovascular Dysfunction Caused by Neonatal Seizures

Liu

Fedinec

Leffler

et al. 2014

J Cereb Blood Flow Metab

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“…In ADL, the use of PPG is for instance researched to detect PR changes in patients with epilepsy [20], as this can indicate seizures [21]. Susceptibility to motion hampers beat-to-beat analysis, e.g., to obtain pulse rate variability (PRV) [22], or to detect atrial fibrillation [23].…”

mentioning

confidence: 99%

Reduction of Periodic Motion Artifacts in Photoplethysmography

Wijshoff

Mischi²,

Aarts³

2017

IEEE Trans. Biomed. Eng.

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Abstract-Periodic motion artifacts affect photoplethysmography (PPG) signals in activities of daily living (ADL), cardiopulmonary exercise testing (CPX), and cardiopulmonary resuscitation (CPR). This hampers measurement of inter-beat-intervals (IBIs) and oxygen saturation (SpO2). Our objective was to develop a generic algorithm to remove periodic motion artifacts, recovering artifact-reduced PPG signals for beat-to-beat analysis. Methods: The algorithm was retrospectively evaluated on forehead PPG signals measured while walking on a treadmill. The step rate was tracked in a motion reference signal via a secondorder generalized-integrator with a frequency-locked loop. Two reference signals were compared: sensor motion relative to the skin (∆x[n]) measured via self-mixing interferometry, and head motion (av[n]) measured via accelerometry. The step rate was used in a quadrature harmonic model to estimate the artifacts. Quadrature components need only two coefficients per frequency leading to a short filter, and prevent undesired frequencyshifted components in the artifact estimate. Subtracting the estimate from the measured signal reduced the artifacts. Results: Compared to ∆x[n], av[n] had a better signal-to-noise ratio and more consistently contained a component at the step rate. Artifact reduction was effective for distinct step rate and pulse rate, since the artifact-reduced signals provided more stable IBI and SpO2 measurements. Conclusion: Accelerometry provided a more reliable motion reference signal. The proposed algorithm can be of significance for monitoring in ADL, CPX or CPR, by providing artifact-reduced PPG signals for improved IBI and SpO2 measurements during periodic motion.

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“…Moreover, the autonomic imbalance in the regulation of cardiac functions is the leading mechanisms of sudden death in epilepsy [3,6]. Some authors suggest using parameters of heart rate as a biomarker refl ecting the risk of status epilepticus [5,10].The causal connection between the brain and the heart is evident [7-9], however, association of cardiovascular and CNS disorders with increasing convulsive readiness (CR) remains poorly understood. For this reason, the study of cardiovascular regulation at different levels of CR will clarify the role of each system and their interrelationship in provoking the pathological processes.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

Heart Rate Regulation at Different Levels of Convulsive Readiness

Мамалыга

2013

Bull Exp Biol Med

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Heart rate variability parameters and the level of convulsive readiness during pentylenetetrazole-induced kindling in rats were analyzed using telemetric ECG and EEG monitoring. Analysis of ECG recorded over many days showed that heart rate variability was equally reduced after 7 and 27 days of kindling irrespective of the level of convulsive readiness. Reduced sympathovagal index after 7 days of kindling showed the compensatory character of changes. However, compensatory mechanisms cannot prevent high risk of life-threatening arrhythmias. High convulsive readiness after 27 days of kindling was accompanied by a shift of autonomic balance towards the increase in sympathetic tone, which may lead to decompensation and transition to a prenosological state.

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A model of heart rate changes to detect seizures in severe epilepsy

Cited by 103 publications

References 14 publications

Enteral Supplements of a Carbon Monoxide Donor CORM-A1 Protect against Cerebrovascular Dysfunction Caused by Neonatal Seizures

Enteral Supplements of a Carbon Monoxide Donor CORM-A1 Protect against Cerebrovascular Dysfunction Caused by Neonatal Seizures

Reduction of Periodic Motion Artifacts in Photoplethysmography

Heart Rate Regulation at Different Levels of Convulsive Readiness

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