A model of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice for the characterisation of intervention therapies

Peiris, Madusha; Monteith, Gregory R.; Roberts‐Thomson, Sarah J.; Cabot, Peter J.

doi:10.1016/j.jneumeth.2007.03.013

Cited by 59 publications

(57 citation statements)

References 56 publications

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“…EAE has been induced in rodents by many kinds of myelin proteins, including myelin basic protein (MBP) (16,17), proteolipid protein (PLP) (18,19), MOG (20 -22), myelin-associated glycoprotein (23), and myelin oligodendrocyte basic protein (24). In particular, MOG peptide is a well-characterized target Ag of encephalitogenic T cells and is used to initiate EAE in the H-2 b C57BL/6 mouse model (25). Recently, MOGinduced EAE attracted interest because MOG-reactive T cells were readily found circulating in MS patients (26,27).…”

Section: Discussionmentioning

confidence: 99%

Essential Role of CD8+CD122+ Regulatory T Cells in the Recovery from Experimental Autoimmune Encephalomyelitis

Lee

Ishida

Rifa’i

et al. 2008

The Journal of Immunology

135

111

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Experimental autoimmune encephalomyelitis (EAE) is one of the best-documented animal models of autoimmune disease. We examined the role of CD8+CD122+ regulatory T cells, which we previously identified as naturally occurring regulatory T cells that effectively regulate CD8+ T cells, in EAE. Depletion of CD8+CD122+ regulatory T cells by in vivo administration of anti-CD122 mAb resulted in persistent EAE symptoms. Transfer of CD8+CD122+ regulatory T cells into EAE mice at the peak EAE score clearly improved symptoms, indicating an important role of CD8+CD122+ regulatory T cells in the recovery phase of EAE. This was further confirmed by an increase and a decrease in the number of infiltrating T cells in the CNS and T cell cytokine production in mice that were depleted of or complemented with CD8+CD122+ cells. Furthermore, transfer of preactivated CD8+CD122+ regulatory T cells resulted in diminished EAE symptoms, especially in the recovery phase of EAE. These results elucidate the essential role of CD8+CD122+ regulatory T cells in the recovery phase of EAE and suggest the preventive effect of preactivated CD8+CD122+ regulatory T cells for EAE.

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Section: Discussionmentioning

confidence: 99%

Essential Role of CD8+CD122+ Regulatory T Cells in the Recovery from Experimental Autoimmune Encephalomyelitis

Lee

Ishida

Rifa’i

et al. 2008

The Journal of Immunology

135

111

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“…The relapsing and remitting form of MS is the most frequent disease course, although some patients develop progressive forms of the disease [5,6]. The etiology of MS is currently unknown and it has been extensively investigated with animal models [7,8].…”

Section: Introductionmentioning

confidence: 99%

Phytosterols ameliorate clinical manifestations and inflammation in experimental autoimmune encephalomyelitis

et al. 2010

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“…A mild EAE model with a relapsing remitting (RR) cycle followed by a complete recovery period can be induced using MOG 35--55 (myelin oligodendrocyte glycoprotein peptide sequence 35--55) and Quil A, which acts once at the site of immunisation [52]. CFA is an adjuvant prepared from killed mycobacteria in water and oil emulsion [50].…”

Section: Refers To Paralysis That Is Usually Observed As a Flaccid Pamentioning

confidence: 99%

Current Developments In Mri For Assessing Rodent Models of Multiple Sclerosis

et al. 2014

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MRI is a key radiological imaging technique that plays an important role in the diagnosis and characterization of heterogeneous multiple sclerosis (MS) lesions. Various MRI methodologies such as conventional T 1/T 2 contrast, contrast agent enhancement, diffusion-weighted imaging, magnetization transfer imaging and susceptibility weighted imaging have been developed to determine the severity of MS pathology, including demyelination/remyelination and brain connectivity impairment from axonal loss. The broad spectrum of MS pathology manifests in diverse patient MRI presentations and affects the accuracy of patient diagnosis. To study specific pathological aspects of the disease, rodent models such as experimental autoimmune encephalomyelitis, virus-induced and toxin-induced demyelination have been developed. This review aims to present key developments in MRI methodology for better characterization of rodent models of MS.

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A model of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice for the characterisation of intervention therapies

Cited by 59 publications

References 56 publications

Essential Role of CD8+CD122+ Regulatory T Cells in the Recovery from Experimental Autoimmune Encephalomyelitis

Essential Role of CD8+CD122+ Regulatory T Cells in the Recovery from Experimental Autoimmune Encephalomyelitis

Phytosterols ameliorate clinical manifestations and inflammation in experimental autoimmune encephalomyelitis

Current Developments In Mri For Assessing Rodent Models of Multiple Sclerosis

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