A model generating the pattern of cartilage skeletal elements in the embryonic chick limb

A Clock and Trail Model for Somite Formation, Specialization and Polarization

“…A model based on a wave gradient was introduced in Wilby & Ede (1975) and Flint et al (1978). It posits that the regression of Hensen's node recruits cells of the paraxial mesoderm into synthesizing a morphogen.…”

A Cell Cycle Model for Somitogenesis: Mathematical Formulation and Numerical Simulation

“…During the last three decades, several models have been proposed to explain the formation of somites: the clock and wavefront model (Cooke & Zeeman, 1976), the wave gradient model (Wilby & Ede, 1975;Flint et al, 1978), a reaction}di!usion-type model (Meinhardt, 1982(Meinhardt, , 1986, the cell cycle model Primmett et al, 1989), the wave and cell polarization model (Polezhaev, 1992(Polezhaev, , 1995a and a clock and induction model . Some of these successfully account for a number of aspects of somitogenesis, but fail to explain, or even contradict other observations (see, for a review .…”

The Cell Programming Language

“…Thus, the cellular aggregate widths and Iresponse can be selected to produce the desired number of precartilage bands. The talpid mutant of the chick has a wider limb bud and not surprisingly a larger number of skeletal elements [22,40], which is predicted by our model. The proximo-distal dimension has no affect on the number of skeletal elements formed.…”

“…18 Wilby and Ede (1975) proposed a model that, given the proximo-distal pattern, simulates the anterior-posterior positioning of skeletal elements [40]. They were able to produce patterning resembling the layout of the bones in the limb (humérus; radius and ulna; metacarpals; digits).…”