2020
DOI: 10.1371/journal.pcbi.1007601
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A model for time interval learning in the Purkinje cell

Abstract: Recent experimental findings indicate that Purkinje cells in the cerebellum represent time intervals by mechanisms other than conventional synaptic weights. These findings add to the theoretical and experimental observations suggesting the presence of intra-cellular mechanisms for adaptation and processing. To account for these experimental results we propose a new biophysical model for time interval learning in a Purkinje cell. The numerical model focuses on a classical delay conditioning task (e.g. eyeblink … Show more

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Cited by 7 publications
(6 citation statements)
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References 49 publications
(59 reference statements)
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“…The complex temporal interplay of ON/OFF excitation and ON inhibition makes the timer unit selective for interval durations (Wehr and Zador, 2003;Edwards et al, 2008;Simen et al, 2011;Takizawa et al, 2012;Naud et al, 2015;Majoral et al, 2018;Rajaram et al, 2019). At the start, the IC soma is charged by mini EPSCs by MSO neurons and discharged by IPSCs by DNLL neurons.…”
Section: Interval-tuned Microcircuitsmentioning
confidence: 99%
“…The complex temporal interplay of ON/OFF excitation and ON inhibition makes the timer unit selective for interval durations (Wehr and Zador, 2003;Edwards et al, 2008;Simen et al, 2011;Takizawa et al, 2012;Naud et al, 2015;Majoral et al, 2018;Rajaram et al, 2019). At the start, the IC soma is charged by mini EPSCs by MSO neurons and discharged by IPSCs by DNLL neurons.…”
Section: Interval-tuned Microcircuitsmentioning
confidence: 99%
“…Those studies, however, have assumed that individual neurons are simple elements that cannot perform complex functions by dendritic computation. In contrast, a few studies have proposed other types of timing mechanisms on single PCs rather than network mechanisms (Fiala et al, 1996 ; Majoral et al, 2020 ). The present study seems consistent with a view that single PCs might be sufficient for temporal information processing in the cerebellum (Johansson et al, 2014 ).…”
Section: Discussionmentioning
confidence: 99%
“…The time course could be regulated over hundreds of ms by regulators of G-protein signaling (RGS proteins) as in the temporal regulation of photoreceptors returning to resting state (Krispel et al, 2006 ) and prolonged inhibition in hippocampal neurons (Xie et al, 2010 ). Purkinje cell modeling by Majoral et al ( 2020 ) and Mandwal et al ( 2021 ) incorporate these components in biochemical cascades, showing that they could replicate part of the phenomena. Until there are more empirical findings on the involved mechanisms, we here aimed at presenting a general model, exploring what is computationally feasible.…”
Section: Discussionmentioning
confidence: 99%
“…Biochemical models that present possible mechanisms for parts of the phenomena have recently been proposed (Majoral et al, 2020 ; Mandwal et al, 2021 ). Given that the currents and molecules involved are yet to be elucidated, here we explore a conceptual and mathematical model of what kind of mechanism could explain all the phenomena described above.…”
Section: Introductionmentioning
confidence: 99%