A model for the pathogenesis of bisphosphonate-associated osteonecrosis of the jaw and teriparatide's potential role in its resolution

Analysis of ADAMTS, MMPs, Versican and Related Proteoglycans in Origin and Progression of BRONJ

“…[36] Collectively, these factors contribute to the hypothesis that following extractions, dental surgical procedures, and trauma, the mandibular expression of ADAMTS-4 and -5 as well as of versican and aggrecan is decreased, and bone remodelling is compromised by bisphosphonates which contributes to impaired healing and tissue regeneration. [36,38] …”

Osteochemonecrosis: An Overview

“…For instance the parathormone analog teriparatide (Forteo Ò ) has been shown to be helpful during the treatment phase of OCN. Because it also has some benefit in the management of low bone density, it offers the advantage of a therapeutic agent other than a bisphosphonate [43][44][45]. Its disadvantages are cost and its ability to only be used for a two-year timeframe.…”

Experience with the treatment of bisphosphonate-related osteonecrosis of the jaw

“…In the pathogenesis defective bone remodelling caused by weakened synergism among the key cells that interact during bone remodeling plays a main role. Disruption of the boneremodelling may be caused by the combination of the underlying disease and the effects of bisphosphonate medication at the lesion site 10 . Minor dentoalveolar surgery such as tooth extraction or chronic trauma of the oral mucosa caused by poorly fitting dentures are common triggering factors of bone exposure.…”