A model for the genesis of arterial pressure Mayer waves from heart rate and sympathetic activity

Myers, Christopher W.; Cohen, Michael A.; Eckberg, Dwain L.; Taylor, J. Andrew

doi:10.1016/s1566-0702(01)00289-2

Cited by 36 publications

(32 citation statements)

References 56 publications

(20 reference statements)

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“…Conversely, a model of human BP by Myers et al (31) showed that the sympathetic activity contributes little to the LF oscillations in BP. In the present work, however, we have demonstrated a strong temporal forward and feedback correlation between the LF fluctuations in SBP and the LF changes in MSNA spike rate in healthy humans at rest.…”

Section: Lf Sbp -Lf Spike Rate Relationmentioning

confidence: 98%

“…A more hotly debated issue is the idea that low-frequency (LF, 0.04 -0.14 Hz) BP oscillations with a 10-s periodicity, generally referred to as Mayer waves, reflect sympathetically mediated vasomotor BP modulation. It has been proposed that the origin of these waves is a resonance phenomenon of the baroreflex pathway (12), and the LF power has been used as a marker of sympathetic activity (34,35,37), although this practice remains controversial (31,48).…”

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confidence: 99%

“…Kamiya et al (23) adapted a transfer function approach used in rabbits to explain the LF fluctuations in human BP and sympathetic activity during tilt but applied this model only to simulated data. In their explanation of human BP fluctuations, Myers et al (31) used a linear model with integrated sympathetic activity as an input parameter, which yielded less accurate results than the transfer functions used in animals. However, the primary concern of this model was explanation of LF BP ; it utilized integrated burst areas with arbitrary units to quantify sympathetic activity, rather than the spike rates typically found in animal models, and involved euglycemic clamping to enhance sympathetic activation, a procedure that induces vasodilation through increased insulin release and may alter the neurovascular coupling (11).…”

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confidence: 99%

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A simplified two-component model of blood pressure fluctuation

Brychta

Shiavi²,

Robertson³

et al. 2007

American Journal of Physiology-Heart and Circulatory Physiology

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September 29, 2006; doi:10.1152/ajpheart.00645.2006.-We propose a simple moving-average (MA) model that uses the low-frequency (LF) component of the peroneal muscle sympathetic nerve spike rate (LFspike rate) and the high-frequency (HF) component of respiration (HFResp) to describe the LF neurovascular fluctuations and the HF mechanical oscillations in systolic blood pressure (SBP), respectively. This method was validated by data from eight healthy subjects (23-47 yr old, 6 male, 2 female) during a graded tilt (15°increments every 5 min to a 60°angle). The LF component of SBP (LFSBP) had a strong baroreflex-mediated feedback correlation with LFspike rate (r ϭ Ϫ0.69 Ϯ 0.05) and also a strong feedforward relation to LFspike rate [r ϭ 0.58 Ϯ 0.03 with LFSBP delay () ϭ 5.625 Ϯ 0.15 s]. The HF components of spike rate (HFspike rate) and SBP (HFSBP) were not significantly correlated. Conversely, HFResp and HFSBP were highly correlated (r ϭ Ϫ0.79 Ϯ 0.04), whereas LFResp and LFSBP were significantly less correlated (r ϭ 0.45 Ϯ 0.08). The mean correlation coefficients between the measured and model-predicted LFSBP (r ϭ 0.74 Ϯ 0.03) in the supine position did not change significantly during tilt. The mean correlation between the measured and model-predicted HFSBP was 0.89 Ϯ 0.02 in the supine position. R 2 values for the regression analysis of the model-predicted and measured LF and HF powers indicate that 78 and 91% of the variability in power can be explained by the linear relation of LFspike rate to LFSBP and HFResp to HFSBP. We report a simple two-component model using neural sympathetic and mechanical respiratory inputs that can explain the majority of blood pressure fluctuation at rest and during orthostatic stress in healthy subjects. wavelet transform; blood pressure variability; Mayer waves; respiration; muscle sympathetic nerve activity VARIOUS RHYTHMIC OSCILLATIONS in human blood pressure (BP) have been proposed to reflect the action of different physiological mechanisms on BP regulation. For instance, it has been suggested that very low-frequency (VLF) trends (period Ͼ25 s, frequency Ͻ0.04 Hz) in BP represent the influence of hormonal regulation and thermoregulation and that high-frequency (HF, 0.15-0.4 Hz) fluctuations mark the effect of respiration on BP. A more hotly debated issue is the idea that low-frequency (LF, 0.04 -0.14 Hz) BP oscillations with a 10-s periodicity, generally referred to as Mayer waves, reflect sympathetically mediated vasomotor BP modulation. It has been proposed that the origin of these waves is a resonance phenomenon of the baroreflex pathway (12), and the LF power has been used as a marker of sympathetic activity (34,35,37), although this practice remains controversial (31, 48).Several lines of indirect evidence have been used to associate the oscillations in BP with oscillations in these other physiological rhythms. For example, physiological maneuvers have identified changes in the oscillatory patterns of sympathetic nerve activity and respiration that correspond to those in BP ...

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Section: Lf Sbp -Lf Spike Rate Relationmentioning

confidence: 98%

mentioning

confidence: 99%

mentioning

confidence: 99%

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A simplified two-component model of blood pressure fluctuation

Brychta

Shiavi²,

Robertson³

et al. 2007

American Journal of Physiology-Heart and Circulatory Physiology

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“…23 Thus, in POTS patients, the higher heart rate compensates for the lower burst incidence at rest, which results in a burst frequency similar to that in controls, and amplifies the burst incidence change during hypotension, which results in an enhanced sympathetic burst frequency response. Because of the response characteristics of the vasculature for burst effects, 29 the total burst number as a function of time (burst frequency) is physiologically more relevant to the vasoconstrictor response than the burst incidence.…”

Section: Nauseamentioning

confidence: 99%

Sympathetic Nerve Activity in Response to Hypotensive Stress in the Postural Tachycardia Syndrome

Bonyhay

Freeman

2004

Circulation

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Background-Increased central sympathetic activity and/or deficient peripheral sympathetic nerve function are among the proposed pathophysiological changes in patients with the postural tachycardia syndrome (POTS). Little is known about sympathetic nerve outflow and its role in hemodynamic control in this disorder. Methods and Results-We recorded peroneal muscle sympathetic nerve activity in 9 POTS patients and 9 control subjects at rest and during a nitroprusside-induced hypotensive stimulus. Baseline blood pressure (BP) and heart rate were significantly higher in POTS patients than in controls. At rest, the burst frequency was similar in POTS patients and controls (18.1Ϯ6.2 and 20.1Ϯ7.9 bursts/min, respectively; PϭNS), whereas the burst incidence was significantly lower (23.1Ϯ6.8 versus 32.2Ϯ11.4 bursts/100 heartbeats, PϽ0.05). Nitroprusside increased sympathetic outflow significantly more in POTS patients than in controls despite a similar BP decrease (burst frequency 20.4Ϯ7.5 versus 12.1Ϯ4.1 bursts/min, Pϭ0.008, and burst incidence 21.8Ϯ8.4 versus 14.4Ϯ5.2 bursts/100 heartbeats, Pϭ0.03). The change in mean burst area, a measure of the number of actively firing sympathetic neurons, was similar in patients and controls (117Ϯ15% versus 114Ϯ21%, PϭNS). Conclusions-At rest, the tachycardia and normal burst frequency result in normal or even elevated BP in POTS patients.During a hypotensive stimulus, cardiovascular homeostasis is maintained by the increased sympathetic outflow and normal heart rate response despite the lack of concomitant increase in mean burst area that is most likely due to sympathetic denervation.

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“…A. et al [66] довгі хвилі також можуть виникати внаслідок ритмічності міо-генних реакцій артеріол. Myers C. W. et al [101] показано, що симпатичні впливи модулюють хвилі Майєра через зміни опору периферійних судин.…”

Section: характеристика та теоретичні основи методів аналізу варіабелunclassified

Characteristics and Theoretical Foundations of Methods to Analyze Heart Rate Variability

Коваленко¹

2017

Ukr. ž. med. bìol. sportu

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Біологічні наукиУкраїнський журнал медицини, біології та спорту -№ 2 (4) 223Проведено аналіз наукових публікацій по істо-рії розробки методів аналізу варіабельності серце-вого ритму, характеристики статистичних, геомет-ричних та спектральних методів коливань гемоди-намічних показників. Проаналізовані дані відносно вимог до тривалості реєстрацій кардіоінтервалог-рам та відтворюваності їх характеристик.Ключові слова: варіабельність серцевого ритму.Зв'язок роботи з науковими програмами, планами і темами. Робота виконана у рамках НДР «Індивідуальні особливості реакцій систем організ-му здорових людей на різноманітні навантаження», № держ. реєстрації 0109U002549.Постановка проблеми. Загальновизнаним та аксіоматичним є положення про те, що прогрес у певних галузях науки визначає розробка методів дослідження. Сучасний етап розвитку суспільства характеризується суттєвими досягненнями у роз-робленні методів вивчення мікроструктури живого організму, а також стрімким розвитком та доступні-стю передових інформаційних технологій. Однією з сфер використання комп'ютерних технологій є оці-нка біологічних ритмів і, зокрема, однієї з їх різно-видів -варіабельності серцевого ритму.Аналіз останніх досліджень і публікацій. Питанням розробки та інтерпретації методів дослі-дження варіабельності коливань хроно-та інотроп-ної діяльності серця присвячена значна кількість оглядів [1,4,8,11,12,15,17,18,24,27,32,29,49,58]. Разом з цим деякі аспекти досліджуваної про-блеми до цього часу висвітлені недостатньо.Мета статті -проаналізувати та узагальнити літературні джерела по методам варіабельності серцевого ритму.Виклад основного матеріалу Історія. Методи оцінки варіабельності серце-вого ритму у вигляді пульсової діагностики з'яви-лись декілька тисячоліть назад [32]. Вперше явище варіабельності тривалості інтервалу часу від поча-тку циклу одного серцевого скорочення до початку іншого описав A. Haller у 1760 році [57]. Вже у од-ному з перших експериментальних досліджень системи кровообігу при катетеризації артерії у коня у 1743 році S. Hales відмітив, що артеріальний тиск

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A model for the genesis of arterial pressure Mayer waves from heart rate and sympathetic activity

Cited by 36 publications

References 56 publications

A simplified two-component model of blood pressure fluctuation

A simplified two-component model of blood pressure fluctuation

Sympathetic Nerve Activity in Response to Hypotensive Stress in the Postural Tachycardia Syndrome

Characteristics and Theoretical Foundations of Methods to Analyze Heart Rate Variability

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