A Model for the Future Care of Acute Spinal Cord Injuries

Botterell, E. H.; Jousse, A T; Kraus, A S; Thompson, Marlene; Wynne-Jones, M; Geisler, W O

doi:10.1017/s0317167100020497

Cited by 47 publications

(23 citation statements)

References 11 publications

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“…The mortality in this series is low and differs little from that in other reports (Botterell et at., 1975;Hardy, 1976). Among the 101 patients, there were seven deaths during the initial period of hospital stay (Table IX).…”

Section: Resultscontrasting

confidence: 90%

Experience with early anterior operation in acute injuries of the cervical spine

et al. 1977

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Abstract. Of 101 patients with acute injury to the cervical spine below the level of the axis, 74 were selected for anterior operation to ensure stability and comfort and to decompress the neural elements when indicated. Forty-six of the patients underwent a Cloward fusion at the level of the injury. Twenty-eight were treated by bar graft fusion. The indications for these procedures and the techniques involved are outlined. A success ful operative result was achieved primarily in 65 of the 74 patients and eventually in 73 patients. The management mortality for patients treated by anterior operation was 2'7 per cent. The advantages of these procedures are the achievement of comfort, the facilitation of early rehabilitation, the maintenance of bony alignment and the preservation and maximal recovery of neurological function.

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Section: Resultscontrasting

confidence: 90%

Experience with early anterior operation in acute injuries of the cervical spine

et al. 1977

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“…It impairs motor, sensory and autonomic functions [1][2][3] . The degree of dysfunction having direct effects on the the quality of life of the affiliated.…”

Section: Introductionmentioning

confidence: 99%

Anti-edema effect of melatonin on spinal cord injury in rats

Li¹,

Yu²,

Yang³

et al. 2015

BIOMED PAP

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, Liangbi Xiang aAim. To determine the anti-edema effects of melatonin on spinal cord injury (SCI) in rats. Methods. A total of 150 adult male Sprague-Dawley rats were randomly allocated to the following three groups (n=50): a sham group which underwent laminectomy without dural compression; an SCI group, which underwent laminectomy followed by SCI and received saline i.p. immediately after injury and then daily for 2 days; an MT group, which underwent laminectomy followed by SCI and received a 100 mg/kg dose of melatonin i.p. immediately after SCI and then daily for 2 days. The cords were removed at 12, 24, 48 and 72 h after surgery in every group. Spinal cord edema was evaluated by determining the spinal cord water content. Expressions of AQP4 and GFAP positive cells in injured spinal cord were detected by immunohistochemical staining, and protein expressions of AQP4 and GFAP were detected by Western blotting. Results. Spinal cord water content was obviously increased after SCI, which was maintained almost unchanged by melatonin treatment (100 mg/kg) at 12 h after injury but was significantly reduced from 24 h to 72 h. The expressions of AQP4 and GFAP increased in the injured spinal cord segments, which were decreased by melatonin treatment (100 mg/kg) between 24 h and 72 h after SCI. Conclusions. Melatonin (100 mg/kg) had anti-edema effects after acute SCI probably by down-regulating the expression level of AQP4 protein, and it may eliminate astrocytic swelling after SCI through down-regulating the expression level of GFAP protein.

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“…Recently Botterill (1975) indicated the need for more full-time personnel. Whilst this may be possible in some parts of the world, in Australia this will be difficult for a long time to come.…”

Section: The Education Of Medical and Paramedical Personnelmentioning

confidence: 99%