A Model for Prediction of Endometrial Cancer

Abstract

An epidemiological statistical model was designed to identify women at low and high risk of developing endometrial cancer (EC). The model was based on a number of easily identified clinical factors such as hirsutism, parity, diabetes mellitus, body mass index (BMI) and smoking. A retrospectively collected series of 77 women aged 31 to 45 years with EC and a prospectively collected series of 122 women aged 43 to 70 years with EC were compared with 1409 controls. The participation frequencies in the two case materials were 83 and 87%, respectively. The series were examined by means of a questionnaire. In a stepwise multiple logistic regression analysis of the entire series the following variables were found to be significant; hirsutism, parity, BMI, diabetes mellitus and smoking.

Is the risk of cancer of the corpus uteri reduced by a recent pregnancy? A prospective study of 765,756 norwegian women

“…The decrease in risk with increasing number of full-term pregnancies observed in the present study is consistent with findings from several other studies (Brinton et al, 1992;Dahlgren et al, 1989;Elwood et al, 1977;Henderson et al, 1983;Inoue et al, 1994;Kelsey et al, 1982;Koumantaki et al, 1989;Kvdle et al, 1988;Miller et al, 1980;Petterson et al, 1986;Shu et a[., 1991). The protective effect of the first pregnancy, however, was more pronounced than that observed for any subsequent pregnancy.…”