A model for educational simulation of the evolution of uterine contractions during labor

Bastos, L.; Meurs, Willem Van; Ayres-de-Campos, Diogo

doi:10.1016/j.cmpb.2011.09.016

Cited by 18 publications

(12 citation statements)

References 30 publications

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“…For consistency, all values are given in three significant digitsSymbolDescriptionValueUnitReferenceP 1 Baseline oxytocin release rate in hypothalamus0.740mU/min[7]P 2 Gain from cervical dilation to oxytocin release rate in hypothalamus50.0mU/(min cm)P 3 Pharmacokinetic parameter: Elimination rate constant0.06931/min[3]P 4 Pharmacokinetic parameter: Volume of distribution18,700mL[8, 9]P 5 Maximal concentration frequency0.5001/min[2]P 6 Pharmacodynamic parameter: Oxytocin concentration resulting in 50% effect7.90mU/mL[3]P 7 Pharmacodynamic parameter: Slope of sigmoidal curve1.11dimensionless[2]P 8 Baseline contraction amplitude40.0mm Hg[10]P 9 Maximal contraction amplitude40.0mm Hg[2]P 10 Dilation increase due to pressure exerted by the fetus on the cervix1.00 × 10 −3 cm/min[11]P 11 Dilation increase due to contraction frequency and amplitude1.90 × 10 −2 cm/mm Hg…”

Section: Methodsmentioning

confidence: 99%

An empirical model for educational simulation of cervical dilation in first-stage labor

et al. 2018

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BackgroundSeveral models for educational simulation of labor and delivery were published in the literature and incorporated into a commercially available training simulator (CAE Healthcare Lucina). However, the engine of this simulator does not include a model for the clinically relevant indicators: uterine contraction amplitude and frequency, and cervical dilation. In this paper, such a model is presented for the primigravida in normal labor.MethodsThe conceptual and mathematical models represent oxytocin release by the hypothalamus, oxytocin pharmacokinetics, and oxytocin effect on uterine contractions, cervical dilation, and (positive) feedback from cervical dilation to oxytocin release by the hypothalamus.ResultsSimulation results for cervical dilation are presented, together with target data for a normal primigravida. Corresponding oxytocin concentrations and amplitude and frequency of uterine contractions are also presented.ConclusionAn original empirical model for educational simulation of oxytocin concentration, uterine contractions, and cervical dilation in first-stage labor is presented. Simulation results for cervical dilation match target data for a normal patient. The model forms a basis for taking into account more independent variables and patient profiles and can thereby considerably expand the range of training scenarios that can be simulated.

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Section: Methodsmentioning

confidence: 99%

An empirical model for educational simulation of cervical dilation in first-stage labor

et al. 2018

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“…At the other end of the spatial scale, several groups have attempted to model uterine electrophysiology at the organ scale. Diverse approaches have been taken, including representing the uterus as a network of discrete contracting cells sending electrical signals to their neighboring cells in simple ellipsoidal geometries and simple compartmental models of function . Models of tissue excitation have also been applied in realistic uterine geometries (Figure ), with partial differential equations describing tissue excitation in a homogenous medium (reaction–diffusion coupled with a Fizhugh‐Nagumo model for ionic currents), and the effect of geometry on wave propagation illustrated.…”

Section: Biomechanics Of the Uterus And Timing Of Deliverymentioning

confidence: 99%

Mathematical modeling of the female reproductive system: from oocyte to delivery

Clark

Kruger

2016

WIREs Mechanisms of Disease

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From ovulation to delivery, and through the menstrual cycle, the female reproductive system undergoes many dynamic changes to provide an optimal environment for the embryo to implant, and to develop successfully. It is difficult ethically and practically to observe the system over the timescales involved in growth and development (often hours to days). Even in carefully monitored conditions clinicians and biologists can only see snapshots of the development process. Mathematical models are emerging as a key means to supplement our knowledge of the reproductive process, and to tease apart complexity in the reproductive system. These models have been used successfully to test existing hypotheses regarding the mechanisms of female infertility and pathological fetal development, and also to provide new experimentally testable hypotheses regarding the process of development. This new knowledge has allowed for improvements in assisted reproductive technologies and is moving toward translation to clinical practice via multiscale assessments of the dynamics of ovulation, development in pregnancy, and the timing and mechanics of delivery. WIREs Syst Biol Med 2017, 9:e1353. doi: 10.1002/wsbm.1353 For further resources related to this article, please visit the WIREs website.

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“…Their features are important to interpret the progress of labour and the significance of certain FHR abnormalities, such as decelerations. Some authors have developed mathematical models for simulation of UC waveforms but without simultaneous simulation of FHR signals [15].…”

Section: Contractionsmentioning

confidence: 99%

“…Under this perspective, the development of software and models to generate synthetic signals with appropriate characteristics is a subject that has been widely investigated also for adult subjects [11,12]. Moreover, the usefulness of simulated heart rate traces with various characteristics for the assessment of diagnostic devices and analysing algorithms has been shown in different studies, both on adult and on foetal heart signals [13][14][15]. Encouraged from the above highlighted results, in this paper, we present a recent upgrade of a novel software for simulating CTG recordings relative to different foetal conditions and recording situations.…”

Section: Introductionmentioning

confidence: 99%

Computerized Cardiotocography: A Software to Generate Synthetic Signals

A¹

2014

J Health Med Informat

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In recent years there has been an increasing interest in developing computerized methods to analyse cardiotocographic recordings, due to the widespread use of cardiotocography to record foetal heart rate and uterine activity signals and the recognized inter and intra-observer variability in the visual evaluation of these signals, in recent years there has been an increasing interest in developing computerized methods to analyse cardiotocographic recordings. As a result of this trend, new biomedical software and analysing algorithms have been enforced to replace the traditional interpretation of cardiotocographic traces. Artificial cardiotocographic signals play a predominant role in testing performance of these software. The present study presents a software for simulating synthetic cardiotocographic recordings developed in order to cover a wide range of physiological conditions and recording situations. It allows the simulation of the main features and characteristics of a real cardiotocographic trace (baseline fluctuation, accelerations, decelerations and contractions). Moreover, it permits the simulation of anomalies due to the acquisition system and/ or cardiac arrhythmia (signal loss and outliers). All the parameters used in the simulation can be set and modified at user choice. The proposed software, which generates synthetic signals resembling real cardiotocographic recordings, facilitates the comparison of different signal processing methods in order to establish their performances and could be employed also as a teaching tool for demonstration to medical students and others

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A model for educational simulation of the evolution of uterine contractions during labor

Cited by 18 publications

References 30 publications

An empirical model for educational simulation of cervical dilation in first-stage labor

An empirical model for educational simulation of cervical dilation in first-stage labor

Mathematical modeling of the female reproductive system: from oocyte to delivery

Computerized Cardiotocography: A Software to Generate Synthetic Signals

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