In this paper, the authors present a proposal to support the creation of test cases for software systems under cloud computing environments. This approach is based on Model Driven Engineering (MDE). A Methodology and metamodels are proposed to support the generation of test cases. Specific metamodels for cloud computing environments are provided. Business models are created conform to UML (including profiles) and test cases are created conform to a metamodel that is independent testing platform. Both models are manipulated by model transformation that generates test cases for cloud computing environments. These metamodels are used in conjunction with the tool MT4MDE and SAMT4MDE for developing testing models. An illustrative example helps to understand the proposed approach.