A mode of action-based probabilistic framework of dose-response assessment for nonmutagenic liver carcinogens: a case study of PCB-126
Yun Zhou,
Qiran Chen,
James E Klaunig
et al.
Abstract:A main function of dose-response assessment is to estimate a “safe” dose in the target population to support chemical risk assessment. Typically, a “safe” dose is developed differently for cancer and noncancer effects based on a 2-step procedure, ie, point of departure (POD) derivation and low-dose extrapolation. However, the current dose-response assessment framework is criticized for its dichotomized strategy without integrating the mode of action (MOA) information. The objective of this study was, based on … Show more
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