The aim of this paper is to investigate the effectiveness of combining mobile technologies and sensors to detect harmful particles in the air and address the problem of air pollution caused by traffic and exhaust emissions. The paper contains a systematic literature review of information technology research related to pollution detection in order to point out the main obstacles in the field and propose solutions. Furthermore, the paper presents the development of an Android smartphone-based real-time monitoring system that utilizes an external analog sensor board to acquire and evaluate physical measurements. The proposed system is calibrated for CO gas measurements, and it is compared with a commercial gas analyzer instrument. Results imply that the developed system is capable of detecting concentration levels in the air and that the accuracy is within the range of the industrial device’s accuracy.