A Mobile Application for Exercise Intervention in People Living with HIV

Bonato, Matteo; Turrini, Filippo; Zan, Valentina De; Meloni, Andrea; Plebani, Marta; Brambilla, Elena; Giordani, Alessandra; Vitobello, Chiara; Caccia, Roberta; Piacentini, Maria Francesca; Torre, Antonio La; Lazzarin, Adriano; Merati, Giampiero; Galli, Laura; Cinque, Paola

doi:10.1249/mss.0000000000002125

Cited by 26 publications

(29 citation statements)

References 31 publications

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“…While the study was not designed to make cause and effect inferences, the results suggest an association between exercising via the app and improvement in lower extremity strength (STS), dynamic balance and mobility (TUG), quality of life (PDQ8), and overall improvement (Global Rating of Change). These results are consistent with a beneficial effect of independent exercise using other smartphone apps in other clinical populations [50].…”

Section: Principal Findingssupporting

confidence: 87%

A Mobile App Specifically Designed to Facilitate Exercise in Parkinson Disease: Single-Cohort Pilot Study on Feasibility, Safety, and Signal of Efficacy (Preprint)

Landers¹,

Ellis²

2020

Preprint

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BACKGROUND Many people with Parkinson disease do not have access to exercise programs that are specifically tailored to their needs and capabilities. This mobile application (app) allows people with Parkinson disease (PD) to access PD-specific exercises that are individually tailored using in-app demographic questions and performance tests which are fed into an algorithm which in turn produces a video-guided exercise program. OBJECTIVE To test the feasibility, safety, and signal of efficacy of a mobile app that facilitates exercise for people with PD. METHODS A prospective, single cohort design of people with PD who had downloaded the 9zest app for exercise was used for this 12 week pilot study. Participants were encouraged to exercise with the app for ≥150 minutes each week. The primary endpoints were feasibility (app usage and usability questions) and safety (adverse events and falls). The primary endpoints for signal of efficacy were a comparison of the in-app baseline and 8 week outcomes on the 30 second Sit-To-Stand (STS), Timed Up and Go (TUG), and the Parkinson’s Disease Questionnaire 8 (PDQ8). RESULTS For feasibility, of the 28 participants that completed the study, 12 participants averaged >150 minutes of app usage per week (3 averaged 120-150, 4 averaged 90-120, and 9 averaged less than 90 minutes). A majority of participants (>73.7%) felt the exercise was of value, provided adequate instruction, and was appropriate for level of function. For safety, there were no serious adverse events that occurred during the app-guided exercise. There were 4 reports of strain/sprain injuries while using the app among 3 participants, none of which necessitated medical attention. For single of efficacy, there was improvement for each of the primary endpoints: STS (P=.008), TUG (P<.001), and PDQ8 (P=.008). CONCLUSIONS Independent, video-guided exercise using a mobile app designed for exercise in PD was safe and feasible though there was variability in app usage. Despite this, the results provide evidence for a signal of efficacy as there were improvements in 3 of the 3 outcomes. CLINICALTRIAL Fox Trial Finder ID: 005206; Clinicaltrials.gov Identifier: NCT03459586

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Section: Principal Findingssupporting

confidence: 87%

A Mobile App Specifically Designed to Facilitate Exercise in Parkinson Disease: Single-Cohort Pilot Study on Feasibility, Safety, and Signal of Efficacy (Preprint)

Landers¹,

Ellis²

2020

Preprint

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“…However, strategies available in the literature are several, and even unorthodox approaches to increase the access of PLHIV to PA produced promising results. For instance, a recent controlled trial conducted in Italy, has shown that exercising with the support of a smartphone application was capable to improve physical fitness, metabolic, and psychological outcomes of middle-aged patients ( 40 ).…”

Section: Discussionmentioning

confidence: 99%

Physical activity among women of low socioeconomic status living with HIV in two major cities of Brazil and Mozambique: A cross-sectional comparative study

Mangona¹,

Brasil²,

Borges³

et al. 2020

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OBJECTIVES: Physical activity (PA) may reduce cardiovascular risk and preserve functional capacity of people living with human immunodeficiency virus (HIV). However, only limited research objectively measured PA in patients with low socioeconomic status (SES) in low-income countries, particularly in South America and sub-Saharan Africa. This study compared the PA assessed by accelerometers in women of low SES living with HIV under common antiretroviral therapy (cART) from two major cities in Brazil (Rio de Janeiro, n=33; 40.1±6.1 years) and Mozambique (Maputo, n=50; 38.8±8.7 years). METHODS: Eligible women wore triaxial accelerometers during seven consecutive days, to estimate their habitual PA and daily energy expenditure. RESULTS: The proportion of participants with overweight/obesity was greater in Rio than Maputo (57% vs . 30%; p =0.021), as well as those classified as sedentary based on steps/day (45% vs. 22%; p =0.02). Sedentary time was prevalent (Median±IQD: Rio-1236±142 vs. Maputo-1192±135 min/day; p =0.15). Time spent in PA was short, but Brazilians exhibited lower amount of light (111±56 vs. 145±51 min/day; p <0.001) and moderate-to-vigorous PA (88±3 vs. 64±36 min/day; p =0.001) vs. Mozambicans. The proportion of patients performing 60 min/day of moderate-to-vigorous PA were 58% (Rio) and 82% (Maputo), respectively. Despite of this, estimated daily energy expenditure was equivalent in both groups (1976±579 vs. 1933±492 kcal; p =0.731). CONCLUSIONS: Women with low SES living with HIV in Maputo were more active vs. patients from Rio de Janeiro. Albeit sedentary behavior was prevalent, the proportion of patients complying with the minimum recommended PA for health was higher than values usually reported in developed countries.

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“…For example, interactive video-game systems that combine gaming and PA (also known as exergames), and exercise programs delivered via digital platforms (e.g., smartphone apps) also are plausible alternative strategies to encourage PA participation, and improve quality of life (Sween et al, 2014 ; Romeo et al, 2019 ). Exergaming through novel mediums such as virtual reality (VR), and digital behavior change apps provide a multisensory and immersive environment that is customizable to the user's functional abilities and personal preferences, and thus may increase motivation for regular PA participation or enhanced adherence (Albergoni et al, 2019 ; Ng et al, 2019 ; Stockwell et al, 2019 ; Bonato et al, 2020 ). For individuals reluctant to participate in PA, the interactive environment of exergames can create a distraction from negative thoughts about PA and encourage the individual to participate in a non-traditional environment (Molina et al, 2014 ; Street et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Make Fitness Fun: Could Novelty Be the Key Determinant for Physical Activity Adherence?

et al. 2020

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A Mobile Application for Exercise Intervention in People Living with HIV

Cited by 26 publications

References 31 publications

A Mobile App Specifically Designed to Facilitate Exercise in Parkinson Disease: Single-Cohort Pilot Study on Feasibility, Safety, and Signal of Efficacy (Preprint)

A Mobile App Specifically Designed to Facilitate Exercise in Parkinson Disease: Single-Cohort Pilot Study on Feasibility, Safety, and Signal of Efficacy (Preprint)

Physical activity among women of low socioeconomic status living with HIV in two major cities of Brazil and Mozambique: A cross-sectional comparative study

Make Fitness Fun: Could Novelty Be the Key Determinant for Physical Activity Adherence?

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