A mixture of quercetin 4′-O-rhamnoside and isoquercitrin from Tilia americana var. mexicana and its biotransformation products with antidepressant activity in mice

Martínez-Hernández, Gabriela Belen; Jiménez-Ferrer, Enrique; Román-Ramos, Rubén; Zamilpa, Alejandro; González-Cortazar, Manasés; León‐Rivera, Ismael; Vargas-Villa, Gabriela; Herrera-Ruíz, Maribel

doi:10.1016/j.jep.2020.113619

Cited by 13 publications

(6 citation statements)

References 32 publications

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“…Additionally, the compounds quercetin, gallic acid, corilagin, and ellagic acid protect against some cytotoxic effects of acetaminophen, microcystins, galactosamine, and lipopolysaccharides [ 46 ]. Therefore, isolation and chromatographic analysis of polyphenolic compounds such as flavonoids, hydroxycinnamic acid derivatives, and organic acids from plants aid in the understanding of their inherited bioactivity [ 47 , 48 , 49 ]. In the case of A. arvensis extracts, it was found that around (8–10 min) ellagitannin was found during chromatographic analysis.…”

Section: Discussionmentioning

confidence: 99%

Ellagitannin, Phenols, and Flavonoids as Antibacterials from Acalypha arvensis (Euphorbiaceae)

Blé-González

Gómez-Rivera

Zamilpa

et al. 2022

Plants

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There is a significant need to gain access to new and better antibacterial agents. Acalypha arvensis, a plant from the Euphorbiaceae family, has been used in traditional medicine for centuries to treat infectious diseases. This manuscript reports the isolation, characterization, and antibacterial screening of 8 natural products extracted from maceration of aerial parts of Acalypha arvensis. Specifically, three extracts were assessed (n-hexane, ethyl acetate, and ethanol), in which antibacterial activity was evaluated against diverse bacterial strains. The ethanolic extract showed the best activity against methicillin-sensitive and methicillin-resistant Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa strains, which supports the medicinal properties attributed to this plant. The chromatographic fractions AaR4 and AaR5 were the most bioactive, in which the ellagitannin natural product known as corilagin (1) was identified for the first time in this plant. Therefore, it can be said that this is the main chemical responsible for the observed antibacterial activity. However, we also identified chlorogenic acid (2), rutin (3), quercetin-3-O-glucoside (4), caffeic acid (5), among others (6–8). Hence, this plant can be considered to be a good alternative to treat health-related issues caused by various bacteria.

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Section: Discussionmentioning

confidence: 99%

Ellagitannin, Phenols, and Flavonoids as Antibacterials from Acalypha arvensis (Euphorbiaceae)

Blé-González

Gómez-Rivera

Zamilpa

et al. 2022

Plants

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“…Among the doses, 150 mg/kg of CS exhibited the strongest antidepressant effect. It is worth noting that quercitrin (Sun et al, 2021), isoquercitrin (Martinez-Hernandez et al, 2021), hypericin (Zhai et al, 2022), chlorogenic acid (Lim et al, 2018), kaempferol (Li et al, 2022) and astragalin (Yao et al, 2022) identified in CS extracts have all been previously reported to have antidepressant effects. Among them, hypericin is also the main component of the traditional antidepressant St. John's Wort, which has shown good antidepressant effects in randomized controlled clinical trials (Linde et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Cuscutae semen alleviates CUS-induced depression-like behaviors in mice via the gut microbiota-neuroinflammation axis

Hou

Yang²,

Zhu³

et al. 2023

Front. Pharmacol.

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Introduction: Major depressive disorder is a mental disease with complex pathogenesis and treatment mechanisms involving changes in both the gut microbiota and neuroinflammation. Cuscutae Semen (CS), also known as Chinese Dodder seed, is a medicinal herb that exerts several pharmacological effects. These include neuroprotection, anti-neuroinflammation, the repair of synaptic damage, and the alleviation of oxidative stress. However, whether CuscutaeSemen exerts an antidepressant effect remains unknown.Methods: In this study, we evaluated the effect of CS on chronic unpredictable stress (CUS)-induced depression-like behaviors in mice by observing changes in several inflammatory markers, including proinflammatory cytokines, inflammatory proteins, and gliocyte activation. Meanwhile, changes in the gut microbiota were analyzed based on 16 S rRNA sequencing results. Moreover, the effect of CS on the synaptic ultrastructure was detected by transmission electron microscopy.Results: We found that the CS extract was rich in chlorogenic acid and hypericin. And CS relieved depression-like behaviors in mice exposed to CUS. Increased levels of cytokines (IL-1β and TNF-α) and inflammatory proteins (NLRP3, NF-κB, and COX-2) induced by CUS were reversed after CS administration. The number of astrocytes and microglia increased after CUS exposure, whereas they decreased after CS treatment. Meanwhile, CS could change the structure of the gut microbiota and increase the relative abundance of Lactobacillus. Moreover, there was a significant relationship between several Lactobacilli and indicators of depression-like behaviors and inflammation. There was a decrease in postsynaptic density after exposure to CUS, and this change was alleviated after CS treatme.Conclusion: This study found that CS treatment ameliorated CUS-induced depression-like behaviors and synaptic structural defects in mice via the gut microbiota-neuroinflammation axis. And chlorogenic acid and hypericin may be the main active substances for CS to exert antidepressant effects.

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“…Staphisagria contains flavonoids such as astragalin, which increase sleep rate and sleep time and decrease sleep latency in combination with sodium pentobarbital [ 11 ]. Rutin and isoquercitrin are active constituents of Staphisagria, with antidepressant activity [ 12 , 13 ]; rutin also decreases some symptoms of chronic stress such as anxiety and improves cognition and locomotor and muscle coordination skills. N. vomica acts mainly on the cerebrospinal nervous system.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Individualized Homeopathy in Treatment-Resistant Depression

Zepeda-Quiroz

Luna-Reséndiz

Soto‐Sanchez

2021

Cureus

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A mixture of quercetin 4′-O-rhamnoside and isoquercitrin from Tilia americana var. mexicana and its biotransformation products with antidepressant activity in mice

Cited by 13 publications

References 32 publications

Ellagitannin, Phenols, and Flavonoids as Antibacterials from Acalypha arvensis (Euphorbiaceae)

Ellagitannin, Phenols, and Flavonoids as Antibacterials from Acalypha arvensis (Euphorbiaceae)

Cuscutae semen alleviates CUS-induced depression-like behaviors in mice via the gut microbiota-neuroinflammation axis

Efficacy of Individualized Homeopathy in Treatment-Resistant Depression

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