A mixture of milk and vegetable lipids in infant formula changes gut digestion, mucosal immunity and microbiota composition in neonatal piglets

Huërou‐Luron, Isabelle Le; Bouzerzour, Karima; Ferret‐Bernard, Stéphanie; Ménard, Olivia; Normand, Laurence Le; Perrier, Cécile; Bourgot, Cindy Le; Jardin, Julien; Bourlieu-Lacanal, Claire; Carton, Thomas; Ruyet, Pascale Le; Cuinet, Isabelle; Bonhomme, Cécile; Dupont, Didier

doi:10.1007/s00394-016-1329-3

Cited by 60 publications

(46 citation statements)

References 49 publications

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“…211 The addition of MFGM alone did not lead to changes in gut microbiota composition in 28-day-old piglets compared with standard IFs but the addition of both dairy lipids and MFGM affected gut microbiota composition, with an increase in Proteobacteria and a decrease in Firmicutes phyla compared with piglets fed a standard vegetable-oil IF. 212 These changes were similar to those observed at 3 months of age between breastfed infants and infants fed a vegetable-oil-based IF. 213 To conclude, relationships have been described between macronutrients and specific bacteria but further studies are needed to better understand them and evaluate their long-term impact on health.…”

Section: Effects Of the If Composition On Gut Microbiota: A Possible supporting

confidence: 76%

Effects of infant formula composition on long-term metabolic health

Lemaire

Huërou‐Luron

Blat

2018

J Dev Orig Health Dis

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Early nutrition may have long-lasting metabolic impacts in adulthood. Even though breast milk is the gold standard, most infants are at least partly formula-fed. Despite obvious improvements, infant formulas remain perfectible to reduce the gap between breastfed and formula-fed infants. Improvements such as reducing the protein content, modulating the lipid matrix and adding prebiotics, probiotics and synbiotics, are discussed regarding metabolic health. Numerous questions remain to be answered on how impacting the infant formula composition may modulate the host metabolism and exert long-term benefits. Interactions between early nutrition (composition of human milk and infant formula) and the gut microbiota profile, as well as mechanisms connecting gut microbiota to metabolic health, are highlighted. Gut microbiota stands as a key actor in the nutritional programming but additional well-designed longitudinal human studies are needed.

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Section: Effects Of the If Composition On Gut Microbiota: A Possible supporting

confidence: 76%

Effects of infant formula composition on long-term metabolic health

Lemaire

Huërou‐Luron

Blat

2018

J Dev Orig Health Dis

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“…But MFGM-supplementation did not change FITC-dextran intestinal permeability, although it improved expression of tight junction proteins. Using neonatal piglets, we also evidenced MFGM-induced mucosal growth without any impact on epithelial permeability as measured in Ussing chambers (Le Huërou-Luron et al, 2018). Moreover, in challenging conditions against pathogenic bacteria such as Clostridium difficile or Listeria monocytogenes, MFGM were described as conferring protection, probably by stimulating mucin secretion and preventing adherence of pathogens to the intestinal mucosa in rats (Sprong et al, 2012;Bhinder et al, 2017).…”

Section: Mfgm Prevents Infection and Improves Gut Barrier Integrity Imentioning

confidence: 71%

“…In a murine model with an early life LPS-induced brain inflammation, the partial replacement of vegetable lipids with dairy lipids had a protective effect on the adverse consequences of LPS exposure on neurogenesis and adult spatial memory (Dinel et al, 2016). In a neonatal piglet model fed IF from birth, the presence of dairy lipids in combination with MGFM changed the dynamic of dairy protein digestion compared to IF containing only vegetable lipids or vegetable lipids plus MFGM, with a higher resistance of casein and b-lactoglobulin to digestion (Le Huërou-Luron et al, 2018). This effect may be related to differences in emulsion interface composition between IFs (Macierzanka et al, 2009).…”

Section: Benefits Of Bovine Milk Fat In Ifsmentioning

confidence: 99%

Health benefits of dairy lipids and MFGM in infant formula

Huërou‐Luron¹,

Lemaire²,

Blat³

2018

OCL

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Human breast milk (HBM) is the gold standard for the early nutrition of the neonates. The best way to improve infant formulas (IFs) is to mimic both the composition and the structure of HBM components. Supplementation of IF with dairy lipids or bovine milk components such as milk fat globule membrane (MFGM), in partial replacement of plant oils that are currently mainly used, has health benefits for infants. In this article, results of clinical studies on the impact of IF supplementation with MFGM and dairy lipids on psychomotor development and infectious disease prevalence in infants are reviewed and supported by recent pre-clinical studies. Numerous human studies have reported beneficial effects of MFGM supplementation on neurocognitive development and protection against infectious agents without deleterious impact on growth. Based on rodent and porcine studies, benefits of adding bovine MFGM and dairy lipids in IFs on gut digestion, physiology and protection against pathogens and inflammatory challenges have also been highlighted. However, more randomized controlled trials testing IF supplementation with bovine milk fat, and specifically apolar lipids and associated glycoproteins, must be performed to increase scientific-based knowledge, address safety concerns, and study its potential programming role of adult health.

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“…Previous studies have indicated that MFGM significantly impacts on the gut microbiota (Bhinder et al., ; Le Huerou‐Luron et al., ; Thompson et al., ). In this study, MFGM significantly affected relative abundance levels of different bacteria, with the addition of the prebiotic blend further enhancing this impact.…”

Section: Discussionmentioning

confidence: 98%

The enduring effects of early‐life stress on the microbiota–gut–brain axis are buffered by dietary supplementation with milk fat globule membrane and a prebiotic blend

O’Mahony

Neufeld

Waworuntu

et al. 2019

Eur J of Neuroscience

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Nutritional interventions targeting the microbiota–gut–brain axis are proposed to modulate stress‐induced dysfunction of physiological processes and brain development. Maternal separation (MS) in rats induces long‐term alterations to behaviour, pain responses, gut microbiome and brain neurochemistry. In this study, the effects of dietary interventions (milk fat globule membrane [MFGM] and a polydextrose/galacto‐oligosaccharide prebiotic blend) were evaluated. Diets were provided from postnatal day 21 to both non‐separated and MS offspring. Spatial memory, visceral sensitivity and stress reactivity were assessed in adulthood. Gene transcripts associated with cognition and stress and the caecal microbiota composition were analysed. MS‐induced visceral hypersensitivity was ameliorated by MFGM and to greater extent with the combination of MFGM and prebiotic blend. Furthermore, spatial learning and memory were improved by prebiotics and MFGM alone and with the combination. The prebiotic blend and the combination of the prebiotics and MFGM appeared to facilitate return to baseline with regard to HPA axis response to the restraint stress, which can be beneficial in times where coping mechanisms to stressful events are required. Interestingly, the combination of MFGM and prebiotic reduced the long‐term impact of MS on a marker of myelination in the prefrontal cortex. MS affected the microbiota at family level only, while MFGM, the prebiotic blend and the combination influenced abundance at family and genus level as well as influencing beta‐diversity levels. In conclusion, intervention with MFGM and prebiotic blend significantly impacted the composition of the microbiota as well as ameliorating some of the long‐term effects of early‐life stress.

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A mixture of milk and vegetable lipids in infant formula changes gut digestion, mucosal immunity and microbiota composition in neonatal piglets

Abstract: The incorporation of both milk fat and MFGM fragments in infant formula modifies protein digestion, the dynamic of the immune system maturation and the faecal microbiota composition.

Cited by 60 publications

References 49 publications

Effects of infant formula composition on long-term metabolic health

Effects of infant formula composition on long-term metabolic health

Health benefits of dairy lipids and MFGM in infant formula

The enduring effects of early‐life stress on the microbiota–gut–brain axis are buffered by dietary supplementation with milk fat globule membrane and a prebiotic blend

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