A mixture ofSalacia oblongaextract and IP-PA1 reduces fasting plasma glucose (FPG) and low-density lipoprotein (LDL) cholesterol levels

Abstract

At present, lifestyle-related diseases are one of the most critical health issues worldwide. It has been reported that lipopolysaccharide derived from a Gram-negative bacteria (IP-PA1) symbiotic with wheat exhibited several advantageous biological effects, such as the reduction of plasma glucose levels in NOD mice and low-density lipoprotein (LDL) levels in WHHL rabbits. In this study, the beneficial effects on plasma glucose and lipids of a tea (SI tea) consisting of IP-PA1 and Salacia (which contains an inhibitor of α-glucosidase) were investigated in the KK-Ay/TaJcl type 2 diabetic model mice and in human subjects with premetabolic syndrome in a double-blind, randomized study. SI tea significantly decreased plasma glucose levels in KK-Ay/TaJcl mice. A clinical trial of SI tea was performed with 41 subjects between the ages of 40 and 69, who belonged either to a high plasma glucose group (HG: FPG 100-125 mg/dl) or to a hyperlipidemia group (HL: TG ≥ 150 mg/dl, or LDL ≥ 120 mg/dl, or HDL < 40 mg/dl). These subjects ingested either Salacia without IP-PA1 (the control) or SI tea. Blood samples were collected at 0, 30, and 60 days after initiating SI tea treatment, and were measured for FPG, HbA1c, TG, LDL, and HDL. These results showed that SI tea reduced FPG and HbA1c more rapidly than the control in the HL group, and also significantly improved LDL and HDL levels in the HG group. Thus, SI tea may be helpful in preventing lifestyle-related diseases.

Effects of 3 months continuous intake of supplement containing Pantoea agglomerans LPS to maintain normal bloodstream in adults: Parallel double‐blind randomized controlled study

“…The decrease in HbA1c was consistent with the results of Nakata et al. (). Since macrophage distinguish denatured protein, such as AGEs, as a foreign matter and eliminate (Ott et al., ), the decrease in HbA1c may be related with phagocytic elimination by macrophages activated through oral administration of LPS.…”

“…In the study on the physiological actions of LPSp derived from P. agglomerans , (1) it was confirmed that stiff neck, malaise, lassitude, visual fatigue, and constipation were improved by the ingestion of LPSp combination Citrus sudachi juice for 3 weeks in 98 males and females aged from 30 to 60; 48.6 μg LPSp/day (open study) (Nakata et al., ). (2) In 47 males and females with high blood glucose levels and serum lipid levels aged from 40 years or older to 70 years or younger, it was confirmed that HbA1c levels and LDL marker were decreased by the ingestion of LPSp Salacia tea for 2 months; 500 μg LPSp/day (double‐blind study) (Nakata et al., ). (3) In 52 females aged from 40 to 79 years, it was confirmed that a decrease in the bone mineral density was suppressed by the ingestion of an LPSp soymilk for 3 months; 600 μg LPSp/day (double‐blind study) (Nakata et al., ).…”

Pantoea agglomerans lipopolysaccharide maintains bone density in premenopausal women: a randomized, double‐blind, placebo‐controlled trial

“…LPSp dose setting was based on previous studies (Nakata et al. ), and the mice ingested LPSp at 0.05 μ g/mL day −1 . The sham‐operated and OVX mice were allowed free access to DW and fermented flour extract for 4 weeks.…”

“…; Nakata et al. ), and atopic dermatitis, as well as preventing infections (Nakamoto et al. ) and reducing pain (Okutomi et al.…”

“…In Europe, live P. agglomerans is also used as a biocontrol agent to prevent the fungal spoilage of fruit (Kamber et al 2012) and it has been confirmed as a safe substance for oral consumption. The effects of P. agglomerans LPS (LPSp) have been reported in animal and human clinical trials, and it has been shown to improve diabetes, dyslipidemia (Iguchi et al 1992;Okutomi et al 1992a;Nakata et al 2011), and atopic dermatitis, as well as preventing infections (Nakamoto et al 2007) and reducing pain (Okutomi et al 1992b,c).…”