A mixture of <i>Lactobacillus</i>
 species isolated from traditional fermented foods promote recovery from antibiotic-induced intestinal disruption in mice

Shi, Ying; Zhao, Xuelin; Zhao, Jianxin; Zhang, H.; Zhai, Qixiao; Narbad, Arjan; Chen, Wei

doi:10.1111/jam.13687

Cited by 45 publications

(42 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although previous studies have shown that probiotics can promote intestinal barrier function and reduce intestinal inflammation, (24,62,(85)(86)(87)(88) in our studies only LR had this beneficial effect. Based on our current results, LR had the ability to alter the Firmicutes:Bacteriodetes ratio, strengthen intestinal barrier function, and reduce intestinal inflammation, whereas LGG did not.…”

Section: Discussioncontrasting

confidence: 77%

“…Previous studies have shown that increased intestinal permeability observed in diseases, such as IBD, is correlated with bone loss . Studies have also shown that ABX‐induced dysbiosis can affect intestinal permeability . Thus, we posited that ABX‐induced dysbiosis decreases bone health through altering intestinal permeability .…”

Section: Resultsmentioning

confidence: 99%

“…How does post-ABX induced dysbiosis promote bone loss? Dysbiosis has been linked to increased intestinal permeability/ leaky gut, (10,21,62) which has been linked to bone loss in diseases such as IBD. (11,22,24,69,81) Our analyses indicate that colon flux significantly negatively correlates with trabecular bone density.…”

Section: Discussionmentioning

confidence: 99%

“…(50) Studies have also shown that ABX-induced dysbiosis can affect intestinal permeability. (61,62) Thus, we posited that ABXinduced dysbiosis decreases bone health through altering intestinal permeability. (24) To test this directly, 2-week ABX mice were given a high-molecular-weight polymer, MDY-1001 (MDY), or vehicle for 4 weeks after cessation of ABX treatment.…”

Section: Antibiotic-induced Dysbiosis Causes Bone Loss Via Gut Barriementioning

confidence: 99%

See 3 more Smart Citations

Probiotic Lactobacillus reuteri Prevents Postantibiotic Bone Loss by Reducing Intestinal Dysbiosis and Preventing Barrier Disruption

Schepper

Collins

Rios‐Arce³

et al. 2019

Journal of Bone and Mineral Research

128

154

View full text Add to dashboard Cite

Antibiotic treatment, commonly prescribed for bacterial infections, depletes and subsequently causes long‐term alterations in intestinal microbiota composition. Knowing the importance of the microbiome in the regulation of bone density, we investigated the effect of postantibiotic treatment on gut and bone health. Intestinal microbiome repopulation at 4‐weeks postantibiotic treatment resulted in an increase in the Firmicutes:Bacteroidetes ratio, increased intestinal permeability, and notably reduced femoral trabecular bone volume (approximately 30%, p < 0.01). Treatment with a mucus supplement (a high‐molecular‐weight polymer, MDY‐1001 [MDY]) prevented the postantibiotic‐induced barrier break as well as bone loss, indicating a mechanistic link between increased intestinal permeability and bone loss. A link between the microbiome composition and bone density was demonstrated by supplementing the mice with probiotic bacteria. Specifically, Lactobacillus reuteri, but not Lactobacillus rhamnosus GG or nonpathogenic Escherichia coli, reduced the postantibiotic elevation of the Firmicutes:Bacteroidetes ratio and prevented femoral and vertebral trabecular bone loss. Consistent with causing bone loss, postantibiotic‐induced dysbiosis decreased osteoblast and increased osteoclast activities, changes that were prevented by both L. reuteri and MDY. These data underscore the importance of microbial dysbiosis in the regulation of intestinal permeability and bone health, as well as identify L. reuteri and MDY as novel therapies for preventing these adverse effects. © 2018 American Society for Bone and Mineral Research.

show abstract

Section: Discussioncontrasting

confidence: 77%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Antibiotic-induced Dysbiosis Causes Bone Loss Via Gut Barriementioning

confidence: 99%

See 2 more Smart Citations

Probiotic Lactobacillus reuteri Prevents Postantibiotic Bone Loss by Reducing Intestinal Dysbiosis and Preventing Barrier Disruption

Schepper

Collins

Rios‐Arce³

et al. 2019

Journal of Bone and Mineral Research

128

154

View full text Add to dashboard Cite

show abstract

“…In addition, mixtures of lactic bacteria obtained from fermented products restore the integrity of the microbiota by enhancing the gut barrier following an exposure to antibiotics in certain intervals [70]. There are novel techniques which facilitate the manipulation of the gut microflora by suppressing pathogens in the epithelium and intestines, in order to regulate the activity of immune cells [71].…”

Section: The Relevance Of Gut Microflora In Parkinson's Disease Pathomentioning

confidence: 99%

Minireview on the Relations between Gut Microflora and Parkinson’s Disease: Further Biochemical (Oxidative Stress), Inflammatory, and Neurological Particularities

Ilie

Ciobîcă

McKenna

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

The aetiology of Parkinson’s disease (PD) is a highly debated topic. Despite the progressive increase in the number of patients diagnosed with PD over the last couple of decades, the causes remain largely unknown. This report is aimed at highlighting the main features of the microbial communities which have been termed “the second brain” that may be a major participant in the etiopathophysiology of PD. It is possible that dysbiosis could be caused by an overactivity of proinflammatory cytokines which act on the gastrointestinal tract as well as infections. The majority of patients who are diagnosed with PD display gastrointestinal symptoms as one of the earliest features. In addition, an unbalanced cycle of oxidative stress caused by dysbacteriosis may have the effect of gradually promoting PD’s specific phenotype. Thus, it seems that bacteria possess the ability to manipulate the brain by initiating specific responses, defining their capability to configure the human body, with oxidative stress playing a pivotal role in preventing infections but also in activating related signalling pathways.

show abstract

Lactiplantibacillus plantarum ELF051 Alleviates Antibiotic-Associated Diarrhea by Regulating Intestinal Inflammation and Gut Microbiota

Liang,

Gao,

Zhao

et al. 2023

Probiotics & Antimicro. Prot.

View full text Add to dashboard Cite

Probiotics are widely recognized for their ability to prevent and therapy antibiotic-associated diarrhea (AAD). This study was designed to evaluate Lactiplantibacillus plantarum ELF051 ability to prevent colon inflammation and its effect on gut microbial composition in a mouse model of AAD. The mice were intragastrically administered triple antibiotics for 7 days and then subjected to L. plantarum ELF051 for 14 days. The administration of L. plantarum ELF051 ameliorated the pathological changes in the colon tissue, downregulated interleukin (IL)-1β and tumor necrosis factor (TNF)-α, and upregulated IL-10, and increased the intestinal short-chain fatty acids (SCFAs) level. Lactiplantibacillus plantarum ELF051 also regulated the Toll-like receptor/myeloid differentiation primary response 88/nuclear factor kappa light chain enhancer of activated B cells (TLR4/MyD88/NF-κB) and the phosphatidylinositol 3-kinase/protein kinase B/ NF-κB (PI3K/AKT/ NF-κB) inflammatory signaling pathways. 16S rRNA analyses showed that L. plantarum ELF051 increased the abundance and diversity of gut bacteria, restoring gut microbiota imbalance. A Spearman’s rank correlation analysis showed that lactobacilli are closely associated with inflammatory markers and SCFAs. This work demonstrated that L. plantarum ELF051 can attenuate antibiotic-induced intestinal inflammation in a mouse AAD model by suppressing the pro-inflammatory response and modulating the gut microbiota.

show abstract

A mixture of Lactobacillus species isolated from traditional fermented foods promote recovery from antibiotic-induced intestinal disruption in mice

Abstract: Consumption of a mixture of Lactobacillus species may encourage faster recovery from antibiotic-induced gut dysbiosis and gut microbiota-related immune disturbance.

Cited by 45 publications

References 57 publications

Probiotic Lactobacillus reuteri Prevents Postantibiotic Bone Loss by Reducing Intestinal Dysbiosis and Preventing Barrier Disruption

Probiotic Lactobacillus reuteri Prevents Postantibiotic Bone Loss by Reducing Intestinal Dysbiosis and Preventing Barrier Disruption

Minireview on the Relations between Gut Microflora and Parkinson’s Disease: Further Biochemical (Oxidative Stress), Inflammatory, and Neurological Particularities

Lactiplantibacillus plantarum ELF051 Alleviates Antibiotic-Associated Diarrhea by Regulating Intestinal Inflammation and Gut Microbiota

Contact Info

Product

Resources

About