A mixture of honey bee products ameliorates the genotoxic side effects of cyclophosphamide

Fahmy, Maha A.; Hassan, Neveen A.; El-Fiky, S.; Elalfy, Heba Gamal

doi:10.1016/s2222-1808(15)60904-5

Cited by 24 publications

(25 citation statements)

References 49 publications

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“…Although it can treat a targeted disease, it slightly can induce oxidative damage caused by its byproduct during biological process (Fahmy et al, 2015). There were studies on the effect of honey to reduce the genotoxic effect induced by mitomycin-C and tamoxifen (Mogib El-Dahtory & Yahia, 2011;Yaacob & Ismail, 2014).…”

Section: Journal Of Agricultural Sciencementioning

confidence: 99%

“…There are several agent that can cause DNA damage such as mitomycin-C (Kumari et al, 2017), cyclophosphamide (Fahmy et al, 2015), carbon tetrachloride (CCl 4 ) (Cheng et al, 2015), malathion (Kandiel et al, 2014), alloxan (2,4,5,6-tetraoxypyrimidine; 5,6-dioxyuracil) (Oršolić et al, 2013), 2,3,7,8-tetrachlorodibenzo-p-dioxin (Türkez et al, 2013, cadmium (Cavuşoğlu et al, 2009), pesticides (Alleva et al, 2016), peroxynitrate (Luo et al, 2007), hydrogen peroxide (Russo et al, 2006) and dimethylhydrazine (Alves De Lima et al, 2005).…”

Section: In Vivo Studiesmentioning

confidence: 99%

“…Mitomycin-C is a drug for treat diseases related to pancreatic, gastric, breast, prostate and bladder cancer (Verweij & Pinedo, 1990) meanwhile cyclophosphamide was used to treat cancer and autoimmune disease. These drugs originally were not in toxic form but when it undergoes enzymatic reduction process in biological system the secondary product will lead to DNA damage (Fahmy et al, 2015;Kumari et al, 2017) and lead to genetic mutation. Study conducted by Kumari et al (2017) and Fahmy et al (2015) proposed that mice treated with mytomycin-C and cyclophosphamide will reduce the DNA damage when following treatment with propolis and royal jelly.…”

Section: In Vivo Studiesmentioning

confidence: 99%

“…Honey can become cytotoxic to the cancer cell similar as tamoxifen, a drug for treatment breast cancer but, at the same time it can reduce formation of free radicals during the biological process (Yaacob & Ismail, 2014). Consumption of any drug can lead to several side effects to health such as development of other diseases at different drug targeted (Fahmy et al, 2015;Mogib El-Dahtory & Yahia, 2011) due to the byproduct formation. Nevertheless, propolis was found to cause damage on DNA molecules when used in higher doses (Pereira et al, 2013).…”

Section: In Vivo Studiesmentioning

confidence: 99%

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Current Knowledge on Honey and Its Derivatives with Genomic Stability: A Mini Review

Yaacob¹,

Stanis²,

Rajab³

et al. 2017

JAS

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Genome health is an important factor that plays a role in various degenerative diseases. Instability of genome is the prevalence of mutation within the genome such as changed in nucleic acid and chromosomal arrangement and also the presence of abnormal number of chromosome in cell. Therefore, several method were used to overcome this problem and one of them is by using natural product such as honey, propolis, bee pollen and royal jelly that is high in antioxidant. Those are products that derive from honey bee and had been used as food supplement to increase the quality of life. Therefore, this systematic review provides the updates on the potential of honey bee products to decrease DNA damage both in in vivo and in vitro approaches. Search term of "honey", "propolis", "bee pollen", royal jelly", "DNA damage", "genome integrity", and "telomere" were used for searching purpose in three databases (Scopus, Pubmed and Medline) and also Google Scholar. All the published articles were assessed using PRISMA guidelines and finally after the eligibility process, only 34 published articles were selected for this review. Based on the reports, the product from the honey bee decrease the genome related diseases by reducing the accumulation of free radical, increase the DNA repair protein expression and decrease the telomerase activity in the cell. This provides a large gap in the research field focusing on the effect of those derivatives from bees on genomic stability.

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Section: Journal Of Agricultural Sciencementioning

confidence: 99%

Section: In Vivo Studiesmentioning

confidence: 99%

Section: In Vivo Studiesmentioning

confidence: 99%

Section: In Vivo Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Current Knowledge on Honey and Its Derivatives with Genomic Stability: A Mini Review

Yaacob¹,

Stanis²,

Rajab³

et al. 2017

JAS

View full text Add to dashboard Cite

show abstract

“…Cyclophosphamide is an effective anti-cancer drug widely used in the treatment of many types of cancers, e.g., acute and chronic leukemia, lymphomas, multiple myeloma, breast cancer, ovarian cancer, neuroblastoma, and sarcoma (Zaki et al 2003). It is also used in immunosuppression disorders (Fahmy et al 2015). In spite of its wide range of medical benefits, it can induce many destructive effects on patients under its treatment (Khan et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Albizia chinensis bark extract ameliorates the genotoxic effect of cyclophosphamide

et al. 2020

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Background The genus Albizia (Leguminoseae) is used in folk medicine for the treatment of a wide range of ailments. Recently, saponins from plant origin have attracted much attention. Saponins are recorded to have a broad range of biological and pharmacological activities. This study was performed to evaluate the protective role of Albizia chinensis bark methanolic extract (MEAC) against the genotoxicity induced by cyclophosphamide (CP) using different mutagenic parameters. Results The results showed that MEAC induced an inhibitory effect against chromosomal aberrations of CP in mouse bone marrow and spermatocytes. Such effect was found to be significant (p < 0.01) with a dose of 100 mg/kg treated once for 24 h and also after repeated treatment at a dose of 25 mg/kg for 7 days. In sperm abnormalities, the protective effect of Albizia extract showed a dose-related relationship. Different doses of MEAC (25, 50, and 100 mg/kg) significantly (p < 0.01) ameliorated sperm abnormalities induced by CP dose-dependently. The percentage of sperm abnormalities was decreased to 5.14 ± 0.72 in the group of animals treated with CP plus MEAC (100 mg/kg) indicating an inhibitory effect of about 50%. Conclusion MEAC at the doses examined was non-genotoxic compared to control (negative) and exhibited a protective role against CP genotoxicity.

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The effect of Anzer honey onX‐rayinduced genotoxicity in human lymphocytes: An in vitro study

Bagatir

Kaya

Suer

et al. 2022

Microscopy Res & Technique

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Anzer honey is well known in Turkey and used for its medicinal properties, especially for pharyngitis, tonsillitis, ulcers and cancer. In this study, we investigated whether Anzer honey, which is shown to have antioxidant, anti-tumoral, and antiinflammatory properties, has a protective effect against X-ray induced genotoxic damage by cytogenetic methods. Peripheral blood lymphocytes isolated from 20 healthy volunteers were divided into two groups and cultivated by conventional methods. Study group lymphocytes were treated with 10% diluted honey while those in the control group were not. Both groups were exposed to a high dose (2 Gy) X-ray at the 48th hour of culture. Conventional cytogenetic staining and Giemsa banding methods were applied to evaluate chromosomal breakage and ring formation. Micronucleus frequencies were determined by the cytokinesis-block micronucleus (CBMN) assay. Paired sample t test was used to compare groups. Anzer honey, which was analyzed melissopalynologically, was used. Micronucleus frequency was significantly decreased in the study group (CI = 348.75 ± 31, median 326, min. 98, max. 704) compared to the control group (CI = 489.10 ± 27, median 500, min. 216, max. 645) (p = .001). Chromosomal breakage was also significantly decreased in the study group (CI = 118.70 ± 16, median 109, min. 12, max. 316) compared to the control group (CI = 233.60 ± 25, median 225, min. 65, max. 492) (p < .0001). This is the first study indicating that genotoxic damage in the peripheral blood lymphocytes of healthy volunteers induced by X-radiation may be prevented or alleviated by adding Anzer honey in vitro. These results encourage further research about the protective effects of honey. Research Highlights• Anzer honey has a genoprotective effect against radiation-induced genotoxicity, probably by preventing oxidation damage.

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A mixture of honey bee products ameliorates the genotoxic side effects of cyclophosphamide

Cited by 24 publications

References 49 publications

Current Knowledge on Honey and Its Derivatives with Genomic Stability: A Mini Review

Current Knowledge on Honey and Its Derivatives with Genomic Stability: A Mini Review

Albizia chinensis bark extract ameliorates the genotoxic effect of cyclophosphamide

The effect of Anzer honey onX‐rayinduced genotoxicity in human lymphocytes: An in vitro study

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