A Mixed Valence Copper Cyanide 3D-supramolecular Coordination Polymer Containing 1,10-Phenathorline Ligand as a Potential Antitumor Agent, Effective Catalyst and Luminescent Material

Etaiw, Safaa El‐din H.; Amer, Said A.; El‐bendary, Mohamed M.

doi:10.1007/s10904-011-9532-4

Cited by 47 publications

(19 citation statements)

References 51 publications

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“…We selected MCF‐7 and HepG‐2 because they are the most common among the various types of carcinomas. The anticancer activity and growth inhibitory activities were specified by IC 50 . IC 50 refers to the concentration of scanned component which minimizes cell growth (by 50%) applying the same conditions.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, structural characterization and DNA binding affinity of new bioactive nano‐sized transition metal complexes with sulfathiazole azo dye for therapeutic applications

Saad

El‐Ghamry

Kassem

2019

Applied Organom Chemis

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The azo dye ligand 4‐(5‐chloro‐2‐hydroxyphenylazo)‐N‐thiazol‐2‐ylbenzenesulfonamide (H2L) formed by the coupling reaction of sulfathiazole and p‐chlorophenol was synthesized and characterized using elemental analysis and Fourier transform infrared (FT‐IR) as well as UV–visible spectra. Nano‐sized divalent Cu, Co, Ni, Mn and Zn complexes of the synthesized azo dye ligand were prepared and investigated using various spectroscopic and analytical techniques. Elemental and thermal analyses indicated the formation of the Cu(II), Ni(II) and Mn(II) complexes in a molar ratio of 1:2 (L:M) while Co(II) and Zn(II) complexes exhibited a 1:1 (M:L) ratio. FT‐IR spectral studies confirmed the coordination of the ligand to the metal ions through the phenolic hydroxyl oxygen, azo nitrogen, sulfonamide oxygen and/or thiazole nitrogen. The geometric arrangements around the central metal ions were investigated applying UV–visible and electron spin resonance spectra, thermogravimetric analysis and molar conductance measurements. X‐ray diffraction patterns revealed crystalline nature of H2L and amorphous nature of all synthesized complexes. Transmission electron microscopy images confirmed nano‐sized particles and their homogeneous distribution over the complex surface. Antibacterial, antifungal and antitumour activities of the investigated complexes were screened compared with familiar standard drugs to confirm their potential therapeutic applications. The Cu(II) complex showed IC50 of 3.47 μg ml−1 (5.53 μM) against hepatocellular carcinoma cells, which means that it is a more potent anticancer drug compared with the standard cisplatin (IC50 = 3.67 μg ml−1 (12.23 μM)). Furthermore, the Co(II), Ni(II), Cu(II) and Zn(II) complexes displayed IC50 greater than that of an applied standard anticancer agent (5‐flurouracil) towards breast carcinoma cells. Hence, these complexes can be considered as promising anticancer drugs. The mode of binding of the complexes with salmon serum DNA was determined through electronic absorption titration and viscosity studies.

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Section: Resultsmentioning

confidence: 99%

Synthesis, structural characterization and DNA binding affinity of new bioactive nano‐sized transition metal complexes with sulfathiazole azo dye for therapeutic applications

Saad

El‐Ghamry

Kassem

2019

Applied Organom Chemis

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“…After 60 min, there is a fast degradation of methyl orange, and degradation efficiency approximately 67.1% for 1 and 75.3% for 2 of the methyl orange dye have been decomposed, respectively. This is may be due to increase of the p-conjugation within the heterocyclic aromatic N-donors, leading to greatly enhanced hydrolytic stability of the compounds which are a necessary condition for catalytic oxidation processes [40,41]. Then, concentration of methyl orange decreases steadily for 1, and finally the degradation percentage is 73.5% after 130 min.…”

Section: Catalytic Propertiesmentioning

confidence: 99%

Structural modulation of Co(II) coordination polymers with flexible bis(benzimidazole) and different dicarboxylate ligands

Wang

et al. 2014

Journal of Molecular Structure

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“…However, the structure features of these SCP are the formation of 3D-networks which contain the rhombic [Cu 2 (l 3 -CN) 2 ] motif or strong Cu…Cu interaction, even shorter than in elemental copper, via interwoven of the sheets [7][8][9]. Such porous networks have potential applications in areas such as separations, gas storage, antitumor, luminescence and catalysis [5,[10][11][12]. In addition, highly luminescent metal-organic materials might be used in sensing systems when molecular absorption of small molecules leads to an alteration in network luminescence behavior [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

3D-Interpenetrating Frameworks of 3∞[Cu2(CN)4(Me3Pb)2(bpy)] Containing the Rhombic [Cu2(µ3-CN)2] Motifs

Etaiw

Abdou

El‐din

2015

J Inorg Organomet Polym

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A supramolecular coordination polymer (SCP), 3 ?[Cu 2 (CN) 4 (Me 3 Pb) 2 (bpy)], 1, based on the Cu n (CN) m building blocks and (Me 3 Pb) ? cation was synthesized in the presence of an auxiliary rigid-planar bipodal 4,4 0 -bipyridine (4,4 0 -bpy) ligand under ambient conditions. The single crystal X-ray diffraction analysis revealed that the Cu(I) sites acquire T-4 geometry and the lead atom, Pb1 assumes TBPY-5 configuration. The rhombic [Cu 2 (l 3 -CN) 2 ] motifs display the essential role as the main building blocks which are interconnected by the (Me 3 Pb) ? cations to form infinite quasi-planer sheets containing the 24-atomic C 8 N 8 Cu 4 Pb 4 rings. These sheets are connected by the bpy ligands producing 3D-network. The wide vacant space present in the framework of 1 is occupied by a second and identical 3D-framework in that each bpy pillar of one framework passes the center of the 24-atomic ring of the complementary framework producing an inextricably interpenetrated structure. The IR, electronic absorption and emission spectra are also investigated. The SCP 1 is an effective catalyst for methylene blue degradation in presence of H 2 O 2 .

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A Mixed Valence Copper Cyanide 3D-supramolecular Coordination Polymer Containing 1,10-Phenathorline Ligand as a Potential Antitumor Agent, Effective Catalyst and Luminescent Material

Cited by 47 publications

References 51 publications

Synthesis, structural characterization and DNA binding affinity of new bioactive nano‐sized transition metal complexes with sulfathiazole azo dye for therapeutic applications

Synthesis, structural characterization and DNA binding affinity of new bioactive nano‐sized transition metal complexes with sulfathiazole azo dye for therapeutic applications

Structural modulation of Co(II) coordination polymers with flexible bis(benzimidazole) and different dicarboxylate ligands

3D-Interpenetrating Frameworks of 3∞[Cu2(CN)4(Me3Pb)2(bpy)] Containing the Rhombic [Cu2(µ3-CN)2] Motifs

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