A mixed-valence biotinylated Cu(<scp>i</scp>/<scp>ii</scp>) complex for tumor-targeted chemodynamic therapy accompanied by GSH depletion

Hong, Zhao-Guo; You, Xin; Zhong, Jingjing; Yao, Di; Bian, He‐Dong; Zhao, Shulin; Zhang, Liangliang; Liang, Hong; Huang, Fu‐Ping

doi:10.1039/d3qi00254c

Cited by 9 publications

(3 citation statements)

References 37 publications

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“…The ROS generation via direct one electron reduction of oxygen by Cu(I)-based reductants is not thermodynamically favored, which argues for more strong oxidants as triggers for the Fenton-like transformations [ 13 , 27 ]. The presence of hydrogen peroxide is commonly demonstrated as the main prerequisite for catalytic activity of Cu(I) complexes in Fenton-like reactions due to Equilibrium 1 [ 1 , 3 – 8 ]. …”

Section: Resultsmentioning

confidence: 99%

“…Cu(I) complexes have gained great attention in recent decades due to their ability to catalyze the Fenton-like reactions leading to the ROS generation, since the latter allows a cell treating through an oxidation stress or the so-called chemodynamic therapy (CDT) [ 1 – 15 ]. In most cases, the ROS generation via the Fenton-like reactions is triggered by hydrogen peroxide or the gentle temperature increase without light irradiation [ 1 – 3 ]. However, developing of Cu(I) complex species exhibiting self-boosting ROS generation is very attractive, but challenging task.…”

Section: Introductionmentioning

confidence: 99%

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ROS-producing nanomaterial engineered from Cu(I) complexes with P2N2-ligands for cancer cells treating

Faizullin,

Dayanova,

Kurenkov

et al. 2023

Discover Nano

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The work presents core–shell nanoparticles (NPs) built from the novel Cu(I) complexes with cyclic P2N2-ligands (1,5-diaza-3,7-diphosphacyclooctanes) that can visualize their entry into cancer and normal cells using a luminescent signal and treat cells by self-enhancing generation of reactive oxygen species (ROS). Variation of P- and N-substituents in the series of P2N2-ligands allows structure optimization of the Cu(I) complexes for the formation of the luminescent NPs with high chemical stability. The non-covalent modification of the NPs with triblock copolymer F-127 provides their high colloidal stability, followed by efficient cell internalization of the NPs visualized by their blue (⁓450 nm) luminescence. The cytotoxic effects of the NPs toward the normal and some of cancer cells are significantly lower than those of the corresponding molecular complexes, which correlates with the chemical stability of the NPs in the solutions. The ability of the NPs to self-enhanced and H2O2-induced ROS generation is demonstrated in solutions and intracellular space by means of the standard electron spin resonance (ESR) and fluorescence techniques correspondingly. The anticancer specificity of the NPs toward HuTu 80 cancer cells and the apoptotic cell death pathway correlate with the intracellular level of ROS, which agrees well with the self-enhancing ROS generation of the NPs. The enhanced level of ROS revealed in HuTu 80 cells incubated with the NPs can be associated with the significant level of their mitochondrial localization.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

ROS-producing nanomaterial engineered from Cu(I) complexes with P2N2-ligands for cancer cells treating

Faizullin,

Dayanova,

Kurenkov

et al. 2023

Discover Nano

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“…13 Our group prepared certain atom-precise biotinylated Cu( i ) or Cu( i )/Cu( ii ) complexes for tumor-targeted CDT. 14,15 Metal–organic macrocycles (MOMs), a type of discrete complex with multiple metal catalytic centers and interesting supermolecular recognition ability, could be a good candidate for CDT research. 16…”

Section: Introductionmentioning

confidence: 99%

Stepwise formation of a chemodynamic therapy agent of {Cu₈} macrocyclic complex recognized by iodide ions

Huang,

Zhong,

Huang

et al. 2023

Dalton Trans.

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Cd/Cd(OH)₂ Nanosheets Enhancing the Electrocatalytic Activity of CO₂ Reduction to CO

Jia,

Qi,

Yang

et al. 2023

Chemistry A European J

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Electric‐driven conversion of carbon dioxide (CO2) to carbon monoxide (CO) under mild reaction conditions offers a promising approach to mitigate the greenhouse effect and the energy crisis. The surface engineering is believed to be one of the prospective methods for enhancing the electrocatalytic activity of CO2 reduction. Herein, the hydroxyl (OH) groups were successfully introduced to cadmium nanosheets to form cadmium and cadmium hydroxide nanocomposites (i.e. Cd/Cd(OH)2 nanosheets) via a facile two‐step method. The as‐prepared Cd/Cd(OH)2/CP (CP indicates carbon paper) electrode displays excellent electrocatalytic activity for CO2 reduction to produce CO. The Faradaic efficiency of CO reaches 98.3% and the current density achieves 23.8 mA cm‐2 at ‐2.0 V vs. Ag/Ag+ in a CO2‐saturated 30 wt% 1‐butyl‐3‐methylimidazole hexafluorophosphate ([Bmim]PF6)‐65 wt% acetonitrile (CH3CN)‐5 wt% water (H2O) electrolyte. And the CO partial current density can reach up to 71.6 mA cm‐2 with the CO Faradaic efficiency of more than 85% at ‐2.3 V vs. Ag/Ag+, which stands out against Cd/CP, Cd(OH)2/CP, and Cd/CdO/CP electrodes. The excellent electrocatalytic performance of the Cd/Cd(OH)2/CP electrode can be attributed to its unique structural properties, suitable OH groups, perfect interaction with electrolyte, abundant active sites and fast electron transfer rate.

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A mixed-valence biotinylated Cu(i/ii) complex for tumor-targeted chemodynamic therapy accompanied by GSH depletion

Abstract: Chemodynamic therapy (CDT), in which highly toxic hydroxyl radicals (•OH) could be triggered by Fenton or Fenton-like reaction to kill cancer cells, has been emerged recently. Compared to traditional CDT...

Cited by 9 publications

References 37 publications

ROS-producing nanomaterial engineered from Cu(I) complexes with P2N2-ligands for cancer cells treating

ROS-producing nanomaterial engineered from Cu(I) complexes with P2N2-ligands for cancer cells treating

Stepwise formation of a chemodynamic therapy agent of {Cu₈} macrocyclic complex recognized by iodide ions

Cd/Cd(OH)₂ Nanosheets Enhancing the Electrocatalytic Activity of CO₂ Reduction to CO

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A mixed-valence biotinylated Cu(i/ii) complex for tumor-targeted chemodynamic therapy accompanied by GSH depletion

Abstract: Chemodynamic therapy (CDT), in which highly toxic hydroxyl radicals (•OH) could be triggered by Fenton or Fenton-like reaction to kill cancer cells, has been emerged recently. Compared to traditional CDT...

Cited by 9 publications

References 37 publications

ROS-producing nanomaterial engineered from Cu(I) complexes with P2N2-ligands for cancer cells treating

ROS-producing nanomaterial engineered from Cu(I) complexes with P2N2-ligands for cancer cells treating

Stepwise formation of a chemodynamic therapy agent of {Cu8} macrocyclic complex recognized by iodide ions

Cd/Cd(OH)2 Nanosheets Enhancing the Electrocatalytic Activity of CO2 Reduction to CO

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Product

Resources

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Stepwise formation of a chemodynamic therapy agent of {Cu₈} macrocyclic complex recognized by iodide ions

Cd/Cd(OH)₂ Nanosheets Enhancing the Electrocatalytic Activity of CO₂ Reduction to CO