A mixed treatment comparison of selected osteopathic techniques used to treat acute nonspecific low back pain: a proof of concept and plan for further research

Abstract

Context Back injuries have a high prevalence in the United States and can be costly for both patients and the healthcare system at large. While previous guidelines from the American College of Physicians for the management of acute nonspecific low back pain (ANLBP) have encouraged nonpharmacologic management, those treatment recommendations involved only superficial heat, massage, acupuncture, and spinal manipulation. Investigation about the efficacy of spinal manipulation in the management of ANLBP is warranted. Objectives To compare the results in previously-published literature documenting the outcomes of osteopathic manipulative treatment (OMT) techniques used to treat ANLBP. The secondary objective of this study was to demonstrate the utility of using Bayesian network meta-analysis (NMA) to perform a mixed treatment comparison (MTC) of a variety of osteopathic techniques. Methods A literature search for randomized controlled trials (RCTs) of ANLBP treatments was performed in April 2020 according to PRISMA guidelines by searching MEDLINE/PubMed, OVID, Cochrane Central, PEDro, and OSTMED.Dr databases; scanning the reference lists of articles; and using the Canadian Agency for Drugs and Technologies in Health grey literature checklist. Each database was searched from inception to April 1, 2020. The following search terms were used: acute low back pain, acute low back pain plus physical therapy, acute low back pain plus spinal manipulation, and acute low back pain plus osteopathic manipulation. The validity of eligible trials was assessed by the single author using an adapted National Institute for Health and Care Excellence methodology checklist for randomized, controlled trials and an extraction form based on that checklist. The outcome measure chosen for this NMA was the Visual Analogue Scale of pain. The NMA were performed using the GeMTC user interface for automated NMA utilizing a Bayesian hierarchical model of random effects. Results The literature search initially found 483 unduplicated records. After screening and full text assessment, five RCTs were eligible for the MTC, yielding a total of 430 participants. Results of the MTC model suggested that there was no statistically significant decrease in reported pain when exercise, high-velocity low-amplitude (HVLA), counterstrain, muscle energy technique, or a mix of techniques were added to conventional treatment to treat ANLBP. However, the rank probabilities assessment determined that HVLA and the OMT mixed treatment protocol plus conventional care were ranked superior to conventional care alone for improving ANLBP. Conclusions While this study failed to provide definitive evidence upon which clinical recommendations can be based, it does demonstrate the utility of performing NMA for MTCs of osteopathic modalities used to treat ANLBP. However, to take full advantage of this statistical technique, future studies should be designed with consideration for the methodological shortcomings found in past osteopathic research.

Nonopioid pharmacological management of acute low back pain: A level I of evidence systematic review

“…The missing contact between patients and health care providers might be one of the reasons why the literature and research regarding acute LBP is scarcer than the one regarding chronic LBP, and conclusions are often discordant 13–15 . Thus, there is limited knowledge regarding the best management for acute LBP, and most meta‐analyses and systematic reviews on the topic report a lack of sufficient data to reach definitive conclusions 13,14,16–24 . According to current guidelines, nonpharmacological treatment should represent the first line of treatment, with pharmacological management can be initiated if the patient wishes it or if first‐line treatment proved to be insufficient 25 .…”

“…[13][14][15] Thus, there is limited knowledge regarding the best management for acute LBP, and most meta-analyses and systematic reviews on the topic report a lack of sufficient data to reach definitive conclusions. 13,14,[16][17][18][19][20][21][22][23][24] According to current guidelines, nonpharmacological treatment should represent the first line of treatment, with pharmacological management can be initiated if the patient wishes it or if first-line treatment proved to be insufficient. 25 However, evidence regarding nonpharmacological treatment of acute LBP is only low to moderate and includes local heat, acupuncture, or massage/manipulations.…”