A mixed spatial prediction model in estimating spatiotemporal variations in benzene concentrations in Taiwan

Hsu, Chin-Yu; Xie, Hong‐Xin; Wong, Pei-Yi; Chen, Yu‐Cheng; Chen, Pau‐Chung; Wu, Chih-Da

doi:10.1016/j.chemosphere.2022.134758

Cited by 12 publications

(3 citation statements)

References 47 publications

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“…The 10‐fold cross validation R 2 s of prediction models for PM 2.5 , O 3 , NO 2 , and benzene were approximately 0.87, 0.85, 0.70, and 0.89, respectively. Detailed information on the collected air pollutant data, geospatial/land‐use datasets, and prediction model procedures is provided elsewhere 19 …”

Section: Methodsmentioning

confidence: 99%

Air pollution associate with advanced hepatic fibrosis among patients with chronic liver disease

Jang,

Ho,

Liang

et al. 2023

The Kaohsiung J of Med Scie

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We aimed to investigate the association between air pollution and advanced fibrosis among patients with metabolic associated fatty liver disease (MAFLD) and chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. A total of 1376 participants who were seropositive for HBV surface antigen (HBsAg) or antibodies to HCV (anti‐HCV) or had abnormal liver function in a community screening program from 2019 to 2021 were enrolled for the assessment of liver fibrosis using transient elastography. Daily estimates of air pollutants (particulate matter ≤2.5 μm in diameter [PM2.5], nitrogen dioxide [NO2], ozone [O3] and benzene) were aggregated into mean estimates for the previous year based on the date of enrolment. Of the 1376 participants, 767 (52.8%) and 187 (13.6) had MAFLD and advanced fibrosis, respectively. A logistic regression analysis revealed that the factors associated with advanced liver fibrosis were HCV viremia (odds ratio [OR], 3.13; 95% confidence interval [CI], 2.05–4.77; p < 0.001), smoking (OR, 1.79; 95% CI, 1.16–2.74; p = 0.01), age (OR, 1.04; 95% CI, 1.02–1.05; p < 0.001) and PM2.5 (OR, 1.10; 95% CI, 1.05–1.16; p < 0.001). Linear regression analysis revealed that LSM was independently correlated with PM2.5 (β: 0.134; 95% CI: 0.025, 0.243; p = 0.02). There was a dose‐dependent relationship between different fibrotic stages and the PM2.5 level (the PM2.5 level in patients with fibrotic stages 0, 1–2 and 3–4: 27.9, 28.4, and 29.3 μg/m3, respectively; trend p < 0.001). Exposure to PM2.5, as well as HBV and HCV infections, is associated with advanced liver fibrosis in patients with MAFLD. There was a dose‐dependent correlation between PM2.5 levels and the severity of hepatic fibrosis.

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Section: Methodsmentioning

confidence: 99%

Air pollution associate with advanced hepatic fibrosis among patients with chronic liver disease

Jang,

Ho,

Liang

et al. 2023

The Kaohsiung J of Med Scie

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“…The detailed information on the collected air pollutant data, geospatial/land-use datasets, and prediction model procedures has been presented in previous studies. [18][19][20]…”

Section: Air Pollution Exposurementioning

confidence: 99%

Air pollution as a potential a risk factor for hepatocellular carcinoma in Taiwanese patients after adjusting for chronic viral hepatitis

Tyng-Yuan,

Ho,

et al. 2024

Journal of the Chinese Medical Association

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Background. Air pollution is a risk factor for hepatocellular carcinoma (HCC). However, the effect of air pollution on HCC risk in patients with hepatitis remains unclear. Methods. This cross-sectional study recruited 348 patients with chronic hepatitis who were tested for serum hepatitis B surface antigen (HBsAg) and for antibodies against hepatitis B core antigen (HBcIgG) and hepatitis C virus (anti-HCV) in 2022. The diagnosis of HCC was based on the International Classification of Diseases, 10 th revision (ICD-10). Daily estimates of air pollutants were aggregated into mean estimates for the previous year based on the date of recruitment or HCC diagnosis. Results. Out of 348 patients, twelve had HCC (3.4%). Patients with HCC were older (71.7 years vs 50.9 year; p=0.004), had higher proportion of HBsAg seropositivity (41.7% vs 5.1%; p<0.001), and substantially higher levels of particulate matter 2.5 (PM2.5) (21.5 μg/m 3 vs 18.2 μg/m 3; p=0.05). Logistic regression analysis revealed that the factors associated with HCC were age (OR: 1.10; CI: 1.03–1.17; p=0.01), PM2.5 level (OR: 1.51; CI: 1.02–2.23; p=0.04), and HBsAg seropositivity (OR: 6.60; CI: 1.51–28.85; p=0.01). There was a combined effect of PM2.5 and HBsAg seropositivity on the risk of HCC development (OR: 22.17; CI: 3.33–147.45; p=0.001). Conclusion. In this study, we demonstrated that PM2.5 and HBsAg seropositivity were associated with HCC occurrence and had synergistic effects after adjusting for confounding factors.

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“…Detailed information on the collected air pollutant data, geospatial/land use datasets, and prediction model procedures was provided elsewhere. [18][19][20]…”

Section: Air Pollution Exposurementioning

confidence: 99%

Air pollution impede ALT normalization in chronic hepatitis B patients treated with nucleotide/nucleoside analogues

Jang,

Ho,

et al. 2023

Medicine

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Biochemical response is an important prognostic indicator in chronic hepatitis B (CHB) patients receiving nucleotide/nucleoside analogues (NAs). However, the effects of air pollution in alanine aminotransferase (ALT) normalization remain elusive. This longitudinal study recruited 80 hepatitis B e antigen–negative CHB patients who received NAs. ALT levels were measured during the first year of anti-hepatitis B virus therapy. Normal ALT levels were defined as <19 U/L for females and <30 U/L for males, and the risk factors associated with ALT abnormalities were analyzed. The daily estimations of air pollutants (particulate matter ≤2.5 µm in diameter (PM2.5), nitrogen dioxide, ozone (O3), and benzene) were aggregated into the mean estimation for the previous month based on the date of recruitment (baseline) and 1 year later. Sixteen patients (20.0%) had a baseline ALT > 40 U/L; overall, 41 (51.6%) had an abnormal ALT (≥19 U/L for females and ≥ 30 U/L for males). After 1 year of NA therapy, 75 patients (93.8%) had undetectable hepatitis B virus DNA levels. Mean post-treatment ALT levels were significantly lower than mean pretreatment levels (21.3 vs 30.0 U/L, respectively; P < .001). The proportion of patients with a normal ALT was also significantly higher after versus before treatment (71.2% vs 51.2%, respectively; P = .001). The strongest factors associated with ALT abnormality after 1 year of NA treatment were body mass index (odds ratio [OR], 1.28; 95% confidence interval [CI], 1.05–1.54; P = .01) and ozone level (OR, 1.11; 95% CI, 1.02–1.22; P = .02). Among hepatitis B e antigen-negative CHB patients with relatively low viral loads, 1 year of NA treatment improved ALT levels after the adjustment for confounding factors and increased the proportion of patients with normal ALT levels. Air pollution affects the efficacy of ALT normalization.

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A mixed spatial prediction model in estimating spatiotemporal variations in benzene concentrations in Taiwan

Cited by 12 publications

References 47 publications

Air pollution associate with advanced hepatic fibrosis among patients with chronic liver disease

Air pollution associate with advanced hepatic fibrosis among patients with chronic liver disease

Air pollution as a potential a risk factor for hepatocellular carcinoma in Taiwanese patients after adjusting for chronic viral hepatitis

Air pollution impede ALT normalization in chronic hepatitis B patients treated with nucleotide/nucleoside analogues

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