A mitochondrial-targeted near-infrared fluorescent probe for visualizing the fluctuation of hypochlorite acid in idiopathic pulmonary fibrosis mice

Methylthio‐substituted coumarin‐based fluorescent probe for highly specific and fast detection of hypochlorite and bioimaging application

“…Such a transformation of functional groups might be used to sense oxidising species. [31][32][33][34] Though a number of alkylthio-substituted coumarin derivatives have been reported for their significant roles in medicinal chemistry and biological chemistry, [59][60][61] their utility as fluorescent probes for ClO À detection has not been developed yet. We designed the probe MOMTC as shown in Scheme 1 based on the following considerations.…”

“…In this regard fluorescent chemosensors receive extensive attention and application in view of their high sensitivity and selectivity, and temporal and spatial resolution for real-time imaging. [12][13][14][15][16][17][18] The design of ClO À fluorescent probes is mainly based on the selective oxidation of specific response groups by ClO À , including C=N double bond, [19][20][21][22][23][24][25][26] C=C double bond, [27][28][29][30] chalcogenide [sulphur (S) and selenium (Se)] atoms, [31][32][33][34][35] amido group, [36][37][38][39][40] p-aminophenol analogues, [41][42][43][44] thiocarbamate moiety, [45][46][47] aryl boronate group, 48,49 carbonsulphur bond 50,51 and several other bonds or groups. [52][53][54] By far people have synthesised a variety of fluorescent probes derived from different fluorophore platforms that specifically detect ClO À in living systems, achieving encouraging advancement in this field.…”

“…The new probe MOMTC having pushÀpull system emitted at farred region and displayed high specificity and rapid response to hypochlorite due to the fact that thioether groups were sensitive to redox thus alkylthio-containing fluorogenic chemosensors tended to exhibit extremely fast reaction rates and high selectivity toward hypochlorite. [15][16][17][18][31][32][33][34] These features made MOMTC an efficient probe for highly specific and prompt detection of hypochlorite over a wide range of pH 3-8. Furthermore, MOMTC had been successfully applied to monitor changes in hypochlorite levels in living cells.…”

“…We designed and synthesised a methylthio‐substituted coumarin (named MOMTC) bearing (methylacryloyloxy)imino moiety as an efficient fluorescent probe for hypochlorite. The new probe MOMTC having push−pull system emitted at far‐red region and displayed high specificity and rapid response to hypochlorite due to the fact that thioether groups were sensitive to redox thus alkylthio‐containing fluorogenic chemosensors tended to exhibit extremely fast reaction rates and high selectivity toward hypochlorite 15–18,31–34 . These features made MOMTC an efficient probe for highly specific and prompt detection of hypochlorite over a wide range of pH 3–8.…”

A phenothiazine and semi-cyanine based colorimetric and fluorescent probe for the rapid detection of hypochlorous acid

“…Fluorescence-based imaging technology, which provides non-invasive, real-time and high-resolution imaging results, is a powerful support tool for HClO detection studies. [14][15][16] These probes can be structurally divided into the following categories: (1) oxidation of CQC 17,18 or CQN 19,20 bonds; (2) oxidation of oximes 21,22 and hydrazines; 23,24 (3) oxidation of p-alkoxyaniline; 25,26 (4) oxidation of sulfur atoms [27][28][29][30][31][32][33][34][35] and some others. [36][37][38] By contrast (the properties of reported probes are listed in ESI † Table S1), sulfur atoms can be used in the construction of probes due to their various forms (thioethers, thioesters, thioacetals, etc.)…”