A mitochondrial nexus in major depressive disorder: Integration with the psycho-immune-neuroendocrine network

Ciubuc-Batcu, M.T.; Stapelberg, N.J.C.; Headrick, J.P.; Renshaw, G.M.C.

doi:10.1016/j.bbadis.2023.166920

Cited by 1 publication

(1 citation statement)

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“…Markedly, a growing body of evidence demonstrates that impaired mitochondrial function is associated with major depressive disorder, and a relationship between mitochondrial dysfunction and GC stress is also important to understand the pathogenesis of depressive disorder [32]. Indeed, studies have demonstrated the critical influence of the mitochondrial system on cognitive processes in the mature brain via regulating NSC fate during neurodevelopment [33] and the role of mitochondrial function in the NAc and CRH neurons in anxiety and stress [34].…”

Section: Glucocorticoids and Neuronal Functionsmentioning

confidence: 99%

An Interaction between Brain-Derived Neurotrophic Factor and Stress-Related Glucocorticoids in the Pathophysiology of Alzheimer’s Disease

Numakawa,

Kajihara

2024

IJMS

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Both the brain-derived neurotrophic factor (BDNF) and glucocorticoids (GCs) play multiple roles in various aspects of neurons, including cell survival and synaptic function. BDNF and its receptor TrkB are extensively expressed in neurons of the central nervous system (CNS), and the contribution of the BDNF/TrkB system to neuronal function is evident; thus, its downregulation has been considered to be involved in the pathogenesis of Alzheimer’s disease (AD). GCs, stress-related molecules, and glucocorticoid receptors (GRs) are also considered to be associated with AD in addition to mental disorders such as depression. Importantly, a growing body of evidence suggests a close relationship between BDNF/TrkB-mediated signaling and the GCs/GR system in the CNS. Here, we introduce the current studies on the interaction between the neurotrophic system and stress in CNS neurons and discuss their involvement in the pathophysiology of AD.

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Section: Glucocorticoids and Neuronal Functionsmentioning

confidence: 99%