A mitochondria-targetable colorimetric and far-red fluorescent probe for the sensitive detection of carbon monoxide in living cells

Wang, Zuokai; Zhao, Ziyang; Wang, Ke; Yuan, Ruifang; Liu, Caiyun; Duan, Qingxia; Zhu, Weiwei; Liu, Xiuyun; Zhu, Baocun

doi:10.1039/c8ay02152j

Cited by 26 publications

(17 citation statements)

References 44 publications

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“…Fluorescent sensors utilize the photoluminescence response triggered by reaction between CO and fluorescent probes for CO measurements in living tissues and aqueous solutions [ 32 , 72 , 73 ]. The transition metal complexes employed in some CO colorimetric, such as ruthenium, iridium, and rhenium, can also be used for fluorescent CO detection [ 56 , 68 , 74 ].…”

Section: Dissolved Co Measurement Methodsmentioning

confidence: 99%

“…The review suggests that direct measurement of DCO concentration might be achieved using colorimetric sensors fabricated with transition metal complexes, fluorescent sensors with transition metal complexes, fluorescent proteins, or palladium catalyzed Tsuji–Trost reaction. However, the drawbacks of colorimetric sensors and fluorescent sensors in the reversibility issue, such as a long recovery time [ 70 ], reagents [ 73 ], and heating [ 84 ] aided reversibility, indicate that these sensors are most appropriate for offline, disposable DCO measurement.…”

Section: Dissolved Co Measurement Methodsmentioning

confidence: 99%

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Review of Dissolved CO and H2 Measurement Methods for Syngas Fermentation

Dang

Wang

Atiyeh

2021

Sensors

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Syngas fermentation is a promising technique to produce biofuels using syngas obtained through gasified biomass and other carbonaceous materials or collected from industrial CO-rich off-gases. The primary components of syngas, carbon monoxide (CO) and hydrogen (H2), are converted to alcohols and other chemicals through an anaerobic fermentation process by acetogenic bacteria. Dissolved CO and H2 concentrations in fermentation media are among the most important parameters for successful and stable operation. However, the difficulties in timely and precise dissolved CO and H2 measurements hinder the industrial-scale commercialization of this technique. The purpose of this article is to provide a comprehensive review of available dissolved CO and H2 measurement methods, focusing on their detection mechanisms, CO and H2 cross interference and operations in syngas fermentation process. This paper further discusses potential novel methods by providing a critical review of gas phase CO and H2 detection methods with regard to their capability to be modified for measuring dissolved CO and H2 in syngas fermentation conditions.

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Section: Dissolved Co Measurement Methodsmentioning

confidence: 99%

Section: Dissolved Co Measurement Methodsmentioning

confidence: 99%

Review of Dissolved CO and H2 Measurement Methods for Syngas Fermentation

Dang

Wang

Atiyeh

2021

Sensors

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“…colourless to pink in aqueous solution makes it suitable for visual detection of CO. Fluctuation of CO levels in living cells also provide an avenue to make it suitable to understand the biological functioning of mitochondrial CO in living HeLa cells. [68] Zhou et al reported a new rhodamine centred mitochondria targetable specific CO detection probe RCO having a reactionbased opening of the spirolactam ring without using Pd 2 + which is distinct in literature. Due to the high allergic and toxic effect Pd 2 + mediated detection of CO is supposed to be less favourable than the palladium free reaction-based detection which is inexpensive as well.…”

Section: Fluorescent Probes For Mitochondrial-targetable Co Detectionmentioning

confidence: 99%

“…reported a far‐red probe FR‐CO for the detection of CO levels in mitochondria of living cells (Figure ). The colorimetric detection of CO by changing colour from colourless to pink in aqueous solution makes it suitable for visual detection of CO. Fluctuation of CO levels in living cells also provide an avenue to make it suitable to understand the biological functioning of mitochondrial CO in living HeLa cells …”

Section: Fluorescent Probes For Mitochondrial‐targetable Co Detectionmentioning

confidence: 99%

Recent Advances in Fluorescence Light‐Up Endogenous and Exogenous Carbon Monoxide Detection in Biology

Mukhopadhyay

Sarkar

Chattopadhyay

et al. 2020

Chemistry An Asian Journal

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Considerable attention has been paid by the scientific community to detect toxic carbon monoxide (CO) in sub-cellular organelles like mitochondria, lysosomes, nuclei, etc. due to their generation and accumulation through numerous biological processes and their role as signal transducer, therapeutics, etc. Various methods are also available for detection of CO, but fluorescence light-up detection is considered the best due to its easy and accurate sensing capability. As of now, no review is available in the literature dedicated to fluorescent detection of only CO both in vitro and in vivo, but considering the huge amount of work reporting every year, it is necessary to have an account of all the recent significant works devoted to it. This review will give special attention to the most noteworthy development of fluorescent light-up probes for the detection of cellular and sub-cellular targetable CO starting from 2012 and emphasizing also the mechanism of action and the applications.

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“…Each detection method has its own unique advantages and has been widely used. With the continuous development of science and technology, among these methods colorimetric fluorescence probes have been given much attention by researchers because they can not only detect analytes by the naked eye, but also have advantages of rapid response, high sensitivity, and selectivity . Among the synthesized and reported fluorescent probes for the detection of NO 2 − , aromatic ortho‐diamines are usually used as probes, and are able to react with NO 2 − to yield benzotriazole derivatives in an acidic medium.…”

Section: Introductionmentioning

confidence: 99%

A colorimetric fluorescent probe for rapid and specific detection of nitrite

Shi

Yang

et al. 2019

Luminescence

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The method of fluorescent probes has been an important technique for detection of nitrite (NO2−). As an important inorganic salt, excessive nitrite would threaten humans and the environment. In this paper, a colorimetric fluorescent probe P‐N (1,2‐diaminoanthraquinone) with rapid response and high selectivity, which could detect NO2− by visual colour changes and fluorescence spectroscopy is presented. The probe P‐N solution (pH 1) changed from pink to colourless with the addition of NO2− and fluorescence intensity at 639 nm clearly decreased. Good linear exists between fluorescence intensities and NO2− concentrations for the range 0–16 μM, and the detection limit was 54 nM (based on a 3σ/slope). Moreover, probe P‐N could also detect NO2− in real water samples, and results were all satisfactory. Probe P‐N shows great practical application value for detecting NO2− in the environment.

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A mitochondria-targetable colorimetric and far-red fluorescent probe for the sensitive detection of carbon monoxide in living cells

Abstract: A simple colorimetric and far-red fluorescent probe was developed for the first time to visualize the gasotransmitter carbon monoxide in subcellular mitochondria.

Cited by 26 publications

References 44 publications

Review of Dissolved CO and H2 Measurement Methods for Syngas Fermentation

Review of Dissolved CO and H2 Measurement Methods for Syngas Fermentation

Recent Advances in Fluorescence Light‐Up Endogenous and Exogenous Carbon Monoxide Detection in Biology

A colorimetric fluorescent probe for rapid and specific detection of nitrite

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