“…These authors comprehensively reviewed all HAE causal genes, including those most recently described, and emphasized the crucial role of next generation sequencing (NGS), specifically whole-exome sequencing (WES), in these recent discoveries. When they dealt with PLG, one of the recently described HAE causal genes, they focused on the p.Lys330Glu mutation, a recurrent mutation described in more than 20 independent families from different European countries and Japan (Belbézier et al, 2018;Bork et al, 2018b;Germenis et al, 2018;Yakushiji et al, 2018;Recke et al, 2019), and also mentioned the p.Lys311Glu variant, described in three patients by Dewald (2018). I would like to clarify that Lys330Glu and Lys311Glu are actually two different names for the same FIGURE 1 | Plasminogen gene structure and location of the c.988A>G/p.Lys330Glu mutation at the DNA and protein level.…”