A minimally invasive method for clinical trans-diaphragmatic pressure measurement in anaesthetized dogs

Pavlidou, Kiriaki; Savvas, Ioannis; Moens, Yves; Vasilakos, D.; Raptopoulos, D.

doi:10.1111/vaa.12073

Cited by 6 publications

(12 citation statements)

References 6 publications

(9 reference statements)

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“…P di value in control group was 11.62±3.54 mmHg and this finding is in accordance with the P di reference published values in our previous study (Pavlidou et al 2013). Regarding the anesthetic protocol, it was the same with the protocol (premedication, induction, maintenance) that has been used in the other two published clinical studies about P di (Pavlidou et al 2013, Pavlidou et al 2014). This anesthetic protocol seems to have a weak effect on diaphragmatic contractility.…”

Section: Discussionsupporting

confidence: 90%

“…The evaluation of diaphragmatic contractility was based on the modified technique for P di measurement with balloon catheters (Pavlidou et al 2014). P di value in control group was 11.62±3.54 mmHg and this finding is in accordance with the P di reference published values in our previous study (Pavlidou et al 2013).…”

Section: Discussionsupporting

confidence: 87%

“…Obese animals were scored as 4 or 5. Furthermore, it has been shown that in very small or large breed dogs, the introduction and proper placement of the balloon catheter into the stomach is difficult and the P gast measurement is inaccurate (Pavlidou et al 2014). Therefore, medium size dogs were used in this study.…”

Section: Methodsmentioning

confidence: 99%

“…To achieve this, the endotracheal tube was disconnected from the anesthetic circuit and tightly closed with a thumb after the end of expiration, so that the animal was forced to breathe against a completely closed airway (Laporta and Grassino 1985;Pavlidou et al 2014) (modified Mueller's maneuver). P gast and P oes were assessed 3 times during a period of 60 minutes independently of the duration of the surgery.…”

Section: Trans-diaphragmatic Pressure Measurementmentioning

confidence: 99%

“…In human medicine, the Mueller's maneuver is an attempt of inspiration with closed mouth and nose (or the glottis). A modified technique for the application of Mueller's maneuver has already been described in dogs under anesthesia in clinical conditions (Pavlidou et al 2014).…”

Section: Introductionmentioning

confidence: 99%

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The effect of aminophylline on trans-diaphragmatic pressure in isoflurane anaesthetised dogs undergoing castration

Pavlidou

Savvas

Moens

et al. 2018

J Hellenic Vet Med Soc

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ABSTRACT. The trans-diaphragmatic pressure (P di )is the main indicator of diaphragmatic contractility and the influence of many different drugs on P di has already been studied. The main aim of this study was to investigate the effect of aminophylline on P di in anaesthetised dogs. Eighteen, healthy, client-owned, male dogs undergoing castration were recruited in the study. All the animals were premedicated with dexmedetomidine and morphine. Anesthesia was induced with propofol to effect and maintained with isoflurane in oxygen. Animals were randomly allocated into two groups. In the animals of the aminophylline group (group A), aminophylline was administered as an intravenous bolus at 4mg/kg after induction, whereas in the animals of the control group (group C), no aminophylline was given. When the surgical plane of anesthesia was achieved, two balloon catheters, one in the stomach and one in the mid-third of the oesophagus were inserted for P di measurement. The two groups differed non-significantly with regards to P di (p=0.182). The results of the study could be viewed as an indication that the aminophylline might increase diaphragmatic contractility if also proven in a larger population of animals'.Keywords: diaphragm, trans-diaphragmatic pressure, oesophageal balloon catheters, dog ΠΕΡΙΛΗΨΗ. Η δια-διαφραγματική πίεση (P di ) είναι ο κύριος δείκτης της συσπαστικότητας του διαφράγματος και η επίδραση αρκετών διαφορετικών φαρμάκων σε αυτήν έχει μελετηθεί. Ο κύριος στόχος αυτής της μελέτης είναι να μελετηθεί η επίδραση της αμινοφυλλίνης στη P di σε σκύλους υπό αναισθησία. Σε αυτή την μελέτη συμπεριλήφθηκαν δεκαοχτώ, υγιείς, ιδιόκτητοι, αρσενικοί σκύλοι οι οποίοι υποβλήθηκαν σε ορχεκτομή. Η προαναισθητική αγωγή σε όλα

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 87%

Section: Methodsmentioning

confidence: 99%

Section: Trans-diaphragmatic Pressure Measurementmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The effect of aminophylline on trans-diaphragmatic pressure in isoflurane anaesthetised dogs undergoing castration

Pavlidou

Savvas

Moens

et al. 2018

J Hellenic Vet Med Soc

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Ultrasound assessment of the diaphragm: Preliminary study of a canine model of X‐linked myotubular myopathy

et al. 2014

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Introduction We tested the feasibility of using neuromuscular ultrasound for non-invasive real time assessment of diaphragmatic structure and function in a canine model of X-Linked Myotubular Myopathy (XLMTM). Methods Ultrasound images in 3 dogs (Wild Type WT, n=1; XLMTM untreated, n=1; XLMTM post AAV8-mediated MTM1 gene replacement, n=1) were analyzed for diaphragm thickness, change in thickness with respiration, muscle echogenicity, and diaphragm excursion amplitude during spontaneous breathing. Results Quantitative parameters of diaphragm structure were different among the animals. WT diaphragm was thicker and less echogenic than the XLMTM control, whereas the diaphragm measurements of the MTM1-treated XLMTM dog were comparable to the WT dog. Discussion This pilot demonstrates the feasibility of using ultrasound for quantitative assessment of the diaphragm in a canine model. Ultrasonography may potentially replace invasive measures of diaphragm function in canine models and in humans in the future, for non-invasive respiratory monitoring and evaluation of neuromuscular disease.

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Aminophylline increases parasternal muscle action in awake canines

Jagers

Rothwell

et al. 2019

Pulmonary Pharmacology & Therapeutics

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A minimally invasive method for clinical trans-diaphragmatic pressure measurement in anaesthetized dogs

Cited by 6 publications

References 6 publications

The effect of aminophylline on trans-diaphragmatic pressure in isoflurane anaesthetised dogs undergoing castration

The effect of aminophylline on trans-diaphragmatic pressure in isoflurane anaesthetised dogs undergoing castration

Ultrasound assessment of the diaphragm: Preliminary study of a canine model of X‐linked myotubular myopathy

Aminophylline increases parasternal muscle action in awake canines

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