A miniaturized stir bar sorptive dispersive microextraction method for the determination of bisphenols in follicular fluid using a magnetic covalent organic framework

Vállez-Gomis, Víctor; Benedé, Juan L.; Lara-Molina, Evelin; López-Nogueroles, Marina; Chisvert, Alberto

doi:10.1016/j.aca.2024.342215

Cited by 5 publications

(1 citation statement)

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“…The technique has been recently scaled down in the so-called miniaturized stir bar sorptive dispersive microextraction (mSBSDME), which presents important advantages. It is adapted to process low-availability samples (e.g., saliva and the follicular fluid) , because of the reduction of the extraction device. It decreases the sorbent and solvent requirements, thus reducing waste generation.…”

Section: Introductionmentioning

confidence: 99%

Coupling Miniaturized Stir Bar Sorptive Dispersive Microextraction to Needle-Based Electrospray Ionization Emitters for Mass Spectrometry: Determination of Tetrahydrocannabinol in Human Saliva as a Proof of Concept

López-Juan,

Millán-Santiago,

Benedé

et al. 2024

Anal. Chem.

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Direct coupling of sample preparation with mass spectrometry (MS) can speed up analysis, enabling faster decision-making. In such combinations, where the analysis time is mainly defined by the extraction procedure, magnetic dispersive solid-phase extraction emerges as a relevant technique because of its rapid workflow. The dispersion and retrieval of the magnetic sorbent are typically uncoupled stages, thus reducing the potential simplicity. Stir bar sorptive dispersive microextraction (SBSDME) is a novel technique that integrates both stages into a single device. Its miniaturization (mSBSDME) makes it more portable and compatible with low-availability samples. This article reports the direct combination of mSBSDME and MS using a needle-based electrospray ionization (NESI) emitter as the interface. This combination is applied to determine tetrahydrocannabinol in saliva samples, a relevant societal problem if the global consumption rates of cannabis are considered. The coupling requires only the transference of the magnet (containing the sorbent and the isolated analyte) from the mSBSDME to the hub of a hypodermic needle, where the online elution occurs. The application of 5 kV on the needle forms an electrospray on its tip, transferring the ionized analyte to the MS inlet. The excellent performance of mSBSDME-NESI-MS/MS relies on the sensitivity (limits of detection as low as 2.25 ng mL–1), the precision (relative standard deviation lower than 15%), and the accuracy (relative recoveries ranged from 87 to 127%) obtained. According to the results, the mSBSDME-NESI-MS/MS technique promises faster and more efficient chemical analysis in MS-based applications.

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Section: Introductionmentioning

confidence: 99%