A miniaturized multicellular platform to mimic the 3D structure of the alveolar-capillary barrier
Michela Licciardello,
Cecilia Traldi,
Martina Cicolini
et al.
Abstract:Several diseases affect the alveoli, and the efficacy of medical treatments and pharmaceutical therapies is hampered by the lack of pre-clinical models able to recreate in vitro the diseases. Microfluidic devices, mimicking the key structural and compositional features of the alveoli, offer several advantages to medium and high-throughput analysis of new candidate therapies. Here, we developed an alveolus-on-a-chip recapitulating the microanatomy of the physiological tissue by including the epithelium, the fib… Show more
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