A Miniature Wireless Silicon-on-Insulator Image Sensor for Brain Fluorescence Imaging

Zhang, Jie; Khalifa, Adam; Spetalnick, Samuel; Alemohammad, Milad; Rattray, John; Thakur, Chetan Singh; Eisape, Adebayo; Etienne‐Cummings, Ralph

doi:10.1109/embc44109.2020.9175405

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…Compared to a 16-mm 2 NIC-powered device (C), we achieved over 4 times larger power density and 5 times larger power. (References : A 25 , B 47 , C 48 , D 49 , E 50 , F 51 , G 52 , H 53 , I 54 )…”

Section: Resultsmentioning

confidence: 99%

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Magnetoelectrics Enables Large Power Delivery to mm-Sized Wireless Bioelectronics

Kim,

Tuppen,

Alrashdan

et al. 2023

Preprint

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To maximize the capabilities of minimally invasive implantable bioelectronic devices, we must deliver large amounts of power to small implants; however, as devices are made smaller, it becomes more difficult to transfer large amounts of power without a wired connection. Indeed, recent work has explored creative wireless power transfer (WPT) approaches to maximize power density (the amount of power transferred divided by receiver footprint area (length x width)). Here, we analyzed a model for WPT using magnetoelectric (ME) materials that convert an alternating magnetic field into an alternating voltage. With this model, we identify the parameters that impact WPT efficiency and optimize the power density. We find that improvements in adhesion between the laminated ME layers, clamping, and selection of material thicknesses lead to a power density of 3.1 mW/mm2, which is over 4 times larger than previously reported for mm-sized wireless bioelectronic implants at a depth of 1 cm or more in tissue. This improved power density allows us to deliver 31 mW and 56 mW to 10-mm2 and 27-mm2 ME receivers, respectively. This total power delivery is over 5 times larger than similarly sized bioelectronic devices powered by radiofrequency electromagnetic waves, inductive coupling, ultrasound, light, capacitive coupling, or previously reported magnetoelectrics. This increased power density opens the door to more power-intensive bioelectronic applications that have previously been inaccessible using mm-sized battery-free devices.

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Section: Resultsmentioning

confidence: 99%

“…We compared the performance of our optimized ME receivers with similarly sized bioelectronic devices of various WPT modalities 25,[47][48][49][50][51][52][53][54] [Fig. 7(b) and Table S3].…”

Section: High Power Density Experimentally Demonstrated Through Porci...mentioning

confidence: 99%

Magnetoelectrics Enables Large Power Delivery to mm-Sized Wireless Bioelectronics

Kim,

Tuppen,

Alrashdan

et al. 2023

Preprint

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“…Fully injectable wirelessly powered devices, or microdevices, play a major role in many emerging biomedical applications including neural monitoring (Lee et al, 2020;Sigurdsson et al, 2020;Zhang et al, 2020), neural stimulation (Freeman et al, 2017;Khalifa et al, 2019), and temperature sensing (Cortese et al, 2020;Shi et al, 2021). Microdevices in this case should not be confused with micro/nanoparticles (Chen et al, 2018;Le et al, 2019;Kozielski et al, 2021) as the latter does not include integrated circuitry.…”

Section: Introductionmentioning

confidence: 99%

Tracking the Migration of Injectable Microdevices in the Rodent Brain Using a 9.4T Magnetic Resonance Imaging Scanner

et al. 2021

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Wirelessly powered microdevices are being miniaturized to improve safety, longevity, and spatial resolution in a wide range of biomedical applications. Some wireless microdevices have reached a point where they can be injected whole into the central nervous system. However, the state-of-the-art floating microdevices have not yet been tested in chronic brain applications, and there is a growing concern that the implants might migrate through neural tissue over time. Using a 9.4T MRI scanner, we attempt to address the migration question by tracking ultra-small devices injected in different areas of the brain (cortico-subcortical) of rats over 5 months. We demonstrate that injectable microdevices smaller than 0.01 mm3 remain anchored in the brain at the targeted injection site over this time period. Based on CD68 (microglia) and GFAP (astrocytes) immunoreactivity to the microdevice, we hypothesize that glial scar formation is preventing the migration of chronically implanted microdevices in the brain over time.

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Bioelectronic devices for light-based diagnostics and therapies

et al. 2023

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Light has broad applications in medicine as a tool for diagnosis and therapy. Recent advances in optical technology and bioelectronics have opened opportunities for wearable, ingestible, and implantable devices that use light to continuously monitor health and precisely treat diseases. In this review, we discuss recent progress in the development and application of light-based bioelectronic devices. We summarize the key features of the technologies underlying these devices, including light sources, light detectors, energy storage and harvesting, and wireless power and communications. We investigate the current state of bioelectronic devices for the continuous measurement of health and on-demand delivery of therapy. Finally, we highlight major challenges and opportunities associated with light-based bioelectronic devices and discuss their promise for enabling digital forms of health care.

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A Miniature Wireless Silicon-on-Insulator Image Sensor for Brain Fluorescence Imaging

Cited by 4 publications

References 16 publications

Magnetoelectrics Enables Large Power Delivery to mm-Sized Wireless Bioelectronics

Magnetoelectrics Enables Large Power Delivery to mm-Sized Wireless Bioelectronics

Tracking the Migration of Injectable Microdevices in the Rodent Brain Using a 9.4T Magnetic Resonance Imaging Scanner

Bioelectronic devices for light-based diagnostics and therapies

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