2011
DOI: 10.1007/s13346-011-0021-7
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A miniature, single use, skin-adhered, low-voltage, electroosmotic pumping-based subcutaneous infusion system

Abstract: A programmable, skin-attached, 36 × 30 × 8 mm system for subcutaneous infusion of 1.2 mL of a drug solution is described. The system is intended to be replaced daily. It comprises a 20 × 14 × 8 mm electronic controller and power source, an 8 mm diameter 2 mm thick electroosmotic pump, a two-compartment reservoir for a pumped water and a drug solution, an adhesive tape for attachment to the skin, and a 6 mm long 27 gauge needle. Its removable electronic controller programs the dose rate and dose and is re-used.… Show more

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Cited by 13 publications
(14 citation statements)
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“…The flux of the driven fluid is linearly dependent on the applied voltage and current. Hence, the fluid delivered can be directly related to the coulomb consumed, the most attractive factor of EOPs, and can be used in monitoring of infused drugs or nutrients in infusion devices a device usually used in a situation where drugs or nutrients are impractical, expensive, or unreliable if delivered manually by nursing staff. Other applications of electroosmotic phenomena are preparation of well-defined arrangement of colloidal particles and controlled transport of biological molecules and complex fluids. , The demonstration in fuel cell applications to remove the water flooding at the cathode and microfluidic devices has been reported.…”
Section: Introductionmentioning
confidence: 99%
“…The flux of the driven fluid is linearly dependent on the applied voltage and current. Hence, the fluid delivered can be directly related to the coulomb consumed, the most attractive factor of EOPs, and can be used in monitoring of infused drugs or nutrients in infusion devices a device usually used in a situation where drugs or nutrients are impractical, expensive, or unreliable if delivered manually by nursing staff. Other applications of electroosmotic phenomena are preparation of well-defined arrangement of colloidal particles and controlled transport of biological molecules and complex fluids. , The demonstration in fuel cell applications to remove the water flooding at the cathode and microfluidic devices has been reported.…”
Section: Introductionmentioning
confidence: 99%
“…The pumps were similar to, but not identical with, those described. , Briefly, 8 mm o.d., 6 mm i.d. pumps were made by sandwiching a phosphosilic acid coated silica membrane between two identical flow-through Ag/Ag 2 O-coated carbon paper electrodes.…”
Section: Methodsmentioning
confidence: 99%
“…For this reason, maintenance of the flow required its dynamic monitoring and adjusting with control, i.e., feedback, loops . Because the Ag/Ag 2 O-ceramic membrane-Ag/Ag 2 O pump has consumable electrodes, it operates at low voltages where water is not electrolyzed. , In the absence of gassing, one would have expected the maintenance of a fixed flow-rate at a particular voltage or current without a control loop, but the actual flow-rate decreased during the operation of the pumps because of accumulation of dissolved Ag + cations.…”
mentioning
confidence: 99%
“…18 Various electrokinetic pump designs have been proposed. 19, 20 The electrolysis pump, for instance, can be applied to generate fluid motion in a microchannel. 16 ACEF flow represents another promising method for fluid pumping in microchannels.…”
Section: Microfluidic Operationsmentioning
confidence: 99%