A Miniature Dual-Fiber Probe for Quantitative Optical Coherence Elastography

Latus, Sarah; Grube, Sarah; Eixmann, Tim; Neidhardt, Maximilian; Gerlach, Stefan; Mieling, Robin; Hüttmann, Gereon; Lutz, Matthias; Schlaefer, Alexander

doi:10.1109/tbme.2023.3275539

Cited by 2 publications

(2 citation statements)

References 31 publications

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“…These two studies demonstrated the capability to perform elastography, but these probes are too oversize, hindering their ability to navigate within lumens for successful in vivo imaging. Latus et.al reported an OCE system with a 5.5-MHz hand-held ultrasound probe for shear wave excitation and a 1-mm dual-fiber probe for detection [ 23 ]. Although they demonstrated the feasibility of endoscopic OCE to quantify elasticity in ex-vivo coronary arteries, they did not integrate the excitation source into the OCE probe.…”

Section: Introductionmentioning

confidence: 99%

In vivo endoscopic optical coherence elastography based on a miniature probe

Xu,

Xia,

Shu

et al. 2024

Biomed. Opt. Express

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Optical coherence elastography (OCE) is a functional extension of optical coherence tomography (OCT). It offers high-resolution elasticity assessment with nanoscale tissue displacement sensitivity and high quantification accuracy, promising to enhance diagnostic precision. However, in vivo endoscopic OCE imaging has not been demonstrated yet, which needs to overcome key challenges related to probe miniaturization, high excitation efficiency and speed. This study presents a novel endoscopic OCE system, achieving the first endoscopic OCE imaging in vivo. The system features the smallest integrated OCE probe with an outer diameter of only 0.9 mm (with a 1.2-mm protective tube during imaging). Utilizing a single 38-MHz high-frequency ultrasound transducer, the system induced rapid deformation in tissues with enhanced excitation efficiency. In phantom studies, the OCE quantification results match well with compression testing results, showing the system's high accuracy. The in vivo imaging of the rat vagina demonstrated the system's capability to detect changes in tissue elasticity continually and distinguish between normal tissue, hematomas, and tissue with increased collagen fibers precisely. This research narrows the gap for the clinical implementation of the endoscopic OCE system, offering the potential for the early diagnosis of intraluminal diseases.

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Section: Introductionmentioning

confidence: 99%

In vivo endoscopic optical coherence elastography based on a miniature probe

Xu,

Xia,

Shu

et al. 2024

Biomed. Opt. Express

View full text Add to dashboard Cite

show abstract

“…Previous methods for endoscopic optical elastography either used acoustic radiation force or intraluminal pressure change as mechanical stimulus [ 18 , 25 – 27 ]. For endoscopic OCE, the former needs the integration of optical and acoustical components [ 28 ], and the latter requires synchronization with imaging speed [ 19 ]. Here we utilize a balloon catheter, which is common to percutaneous interventional procedures [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Learning-based distortion correction enables proximal-scanning endoscopic OCT elastography

Zhang,

Gu,

Lan

et al. 2024

Biomed. Opt. Express

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Proximal rotary scanning is predominantly used in the clinical practice of endoscopic and intravascular OCT, mainly because of the much lower manufacturing cost of the probe compared to distal scanning. However, proximal scanning causes severe beam stability issues (also known as non-uniform rotational distortion, NURD), which hinders the extension of its applications to functional imaging, such as OCT elastography (OCE). In this work, we demonstrate the abilities of learning-based NURD correction methods to enable the imaging stability required for intensity-based OCE. Compared with the previous learning-based NURD correction methods that use pseudo distortion vectors for model training, we propose a method to extract real distortion vectors from a specific endoscopic OCT system, and validate its superiority in accuracy under both convolutional-neural-network- and transformer-based learning architectures. We further verify its effectiveness in elastography calculations (digital image correlation and optical flow) and the advantages of our method over other NURD correction methods. Using the air pressure of a balloon catheter as a mechanical stimulus, our proximal-scanning endoscopic OCE could effectively differentiate between areas of varying stiffness of atherosclerotic vascular phantoms. Compared with the existing endoscopic OCE methods that measure only in the radial direction, our method could achieve 2D displacement/strain distribution in both radial and circumferential directions.

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A Miniature Dual-Fiber Probe for Quantitative Optical Coherence Elastography

Cited by 2 publications

References 31 publications

In vivo endoscopic optical coherence elastography based on a miniature probe

In vivo endoscopic optical coherence elastography based on a miniature probe

Learning-based distortion correction enables proximal-scanning endoscopic OCT elastography

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