A mini-review: phosphodiesterases in charge to balance intracellular cAMP during T-cell activation
Marie Bielenberg,
Roberta Kurelic,
Stefan Frantz
et al.
Abstract:T-cell activation is a pivotal process of the adaptive immune response with 3′,5′-cyclic adenosine monophosphate (cAMP) as a key regulator of T-cell activation and function. It governs crucial control over T-cell differentiation and production of pro-inflammatory cytokines, such as IFN-γ. Intriguingly, levels of intracellular cAMP differ between regulatory (Treg) and conventional T-cells (Tcon). During cell-cell contact, cAMP is transferred via gap junctions between these T-cell subsets to mediate the immunosu… Show more
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