A mini-review on phytochemistry and pharmacological activities of Scrophularia striata

Abstract

Introduction: Scrophularia striata (Scrophulariaceae) is an important medicinal plant in Iran and in Iranian folk medicine it has been used for variety of disorders. The present article aims to provide a review at the studies done on phytochemistry and pharmacological effects of S. striata. Methods: This mini review is based on a literature study of scientific journals from electronic sources, such as Science Direct, PubMed, Google Scholar, Scopus and Web of Science. Results: The main chemical constituents which have been isolated and identified from Scrophularia striata are cinnamic acid, some flavonoids such as quercetin, isorhamnetin3-O-rutinoside and nepitrin and one glycoside (acteoside1) . This plant possesses antiinflammatory , antibacterial , antioxidant, anticancer, analgesic and neuroprotective effects. In addition it accelerates wound healing process Conclusion : Scrophularia striata has a potential for the treatment of several diseases and disorders, but there are only a few studies done to investigate the plant phytochemistry, thus f urther studies should be focused on isolation and identification of active compounds with pharmacological activities. Besides, the majority of pharmacological studies have been performed using aerial parts of plant , thus further studies are needed to investigate bioactivity of other parts of the plant.

Phytotoxic Potential and Phenolic Profile of Extracts from Scrophularia striata

“…The distribution of S. striata occurs predominantly in the arid and semi-arid regions of southwestern Iran [ 5 ]. Alkaloids, phenolics, iridoids, and cryptophilic acids are active constituents that accumulate in different parts of S. striata [ 6 , 7 , 8 ]. In the Iranian folk medicine, this species has been used as a wound healing agent [ 9 ].…”

Constipation: An ethno-botanical study of medicinal plants used for constipation in Shahrekord city, Chaharmahal & Bakhtiari province, Iran

“…Various causes of constipation usually limit its clinical efficacy of the conventional treatments. Medicinal plant usually have mul-tifunction properties [22][23][24][25][26][27][28]. The shortcomings of the current treatments can be completed by medicinal plants which not only are able to target multiple organs of the body but also can reduce their toxic effects [29][30][31][32][33].…”

Study of extraction and chemical compounds of Scrophularia striata Boiss. and Scrophularia deserti Delile using HS-SPME and GC-MS

“…The major chemical compounds isolated and identified from S. striata are cinnamic acid, some flavonoids such as quercetin, isorhamnetin-3-O-rutinoside, nepitrin and a glycoside (octreotide 1). The plant has anti-inflammatory, antibacterial, antioxidant, anticancer, analgesic and neuroprotective as well as wound healing effects [25]. Spathulenol, caryophyllene oxide, linalool, alpha-terpineol, trans-caryophyllene and geraniol alpha-phellandrene, beta-myrcene and trans-caryophyllene can be active ingredients of these two plants that have the above-mentioned therapeutic effects [26][27][28][29][30][31][32][33].…”