A mini-review of anti-hepatitis B virus activity of medicinal plants

Siddiqui, Manzer H.; Alamri, Saud; Al-Whaibi, Mohamed H.; Hussain, Zahid; Ali, Hayssam M.; El-Zaidy, Mohamed

doi:10.1080/13102818.2016.1240593

Cited by 22 publications

(16 citation statements)

References 51 publications

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“…It is a medicinal plant popularly known as stonebreaker, as it has historically been used in the elimination of kidney stones, commonly used as an herbal medicine [ 3 ]. Its clinical effects include antihepatotoxic, antilytic, antihypertensive, anti-inflamatory, anti-human immunodeficiency virus (HIV), and anti-hepatitis B activities [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Calli Production Resulted in Different Profiles of Plant-Derived Medicinal Compounds in Phyllanthus amarus

2020

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The efficient production of plant-derived medicinal compounds (PDMCs) from in vitro plants requires improvements in knowledge about control of plant or organ development and factors affecting the biosynthesis pathway of specific PDMCs under in vitro conditions, leading to a realistic large-scale tool for in vitro secondary metabolite production. Thus, this study aimed to develop an in vitro technique, through the induction and proliferation of calli, for production of plant fresh weight, and to compare the PDMC profile obtained from the plants versus in vitro calli of Phyllanthus amarus. It was successfully possible to obtain and proliferate two types of calli, one with a beige color and a friable appearance, obtained in the dark using Murashige and Skoog (MS) medium plus 2,4-dichlorophenoxyacetic acid (2,4-D), and a second type with a green color, rigid consistency, and nonfriable appearance obtained under light conditions and MS medium plus 6-benzyladenine (6-BA). In vitro micropropagated plants that gave rise to calli were also acclimatized in a greenhouse and cultivated until obtaining the mass for PDMC analysis and used as a control. While the micropropagated-derived plants concentrated the lignans niranthin, nirtetralin, and phyllanthin, the Phyllanthus amarus calli proliferated in vitro concentrated a completely different biochemical profile and synthesis of compounds, such as betulone, squalene, stigmasterol, and β-sitosterol, in addition to others not identified by GC-MS database. These results demonstrate the possibility of applying the calli in vitro from Phyllanthus amarus for production of important PDMCs unlike those obtained in cultures of differentiated tissues from field plants.

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Section: Introductionmentioning

confidence: 99%

In Vitro Calli Production Resulted in Different Profiles of Plant-Derived Medicinal Compounds in Phyllanthus amarus

2020

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“…It has been previously reported that various compounds isolated from these plants display promising bioactivity. 16 A number of medicinal plants from various countries have been tested for anti-HBV to find potential candidates for anti-HBV drug development. The goal of HBV therapy is to prevent the progression of chronic hepatitis B to cirrhosis, end-stage liver disease, hepatocellular carcinoma and death.…”

Section: Discussionmentioning

confidence: 99%

Antiviral Activity of Indonesian Medicinal Plants against Hepatitis B Virus

Wahyuni¹,

Permanasari²,

Widyawaruyanti³

et al. 2020

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Background: Hepatitis B virus (HBV) infects more than 300 million people globally and is a common cause of liver cancer. Current therapy using reverse transcriptase inhibitors require long-term treatment and the potential risk of development of drug-resistant viruses remains an important issue to be considered. Hence, the development of new drugs is critical. Traditional medicinal plants used for the treatment of infectious diseases may provide a viable option for the discovery of anti-HBV drug candidates. Objective: This study examined anti-HBV activity of 31 kinds of Indonesian plants. Materials and Methods: Crude extracts of various part of plants, leaves and stem, were obtained using dichloromethane and ethanol solvent. The effect on viral entry was examined by determining levels of HBsAg expression in the supernatants of HBV-infected HepG2-NTCP cells by ELISA. The effect on HBV replication was determined by measuring HBV DNAs amounts in Hep38.7-Tet cells by quantitative real-time PCR. Results: The extracts of Phyllantus niruri leaves and Curcuma xanthorrhiza showed reduction of strong HBsAg production from HepG2-NTCP cells with IC 50 values of 170.48 and 270.51 μg/mL, respectively. Treatment of HepAD38.7-Tet cells with P. niruri and C. xanthorhiza at the highest concentration while avoiding cytotoxicity reduced extracellular HBV DNA levels by 70% and 30 % of the untreated control respectively. Conclusion: P. niruri inhibited both the entry and HBV replication, thus P. niruri is a promising candidate for anti-HBV drug development.

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“…Nishikori et al 93 95 Elsebai et al 96 concluded that grosheimol and cynaropicrin of wild Egyptian artichoke (Cynara cardunculus L.) are promising candidates for the development of new pan-genotypic entry inhibitors of HCV infection. Siddiqui et al 97 reported that the drugs available on the market for the treatment of hepatitis B are not sufficient and also cause side effects in patients suffering from HBV infection. Wan et al 98 reported that extract of Cananga odorata could be a good candidate for the development of anti-HBV drugs.…”

Section: Reishi Mushroom (Ganoderma Lucidum)mentioning

confidence: 99%

The Function of some Important TCM and Iranian Medicinal Plants in Treatment of Viral Hepatitis

Shahrajabian¹,

Sun²,

Cheng³

2021

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Introduction: Hepatitis is a systematic viral infection which significantly influences the liver and is divided into five types according to the causative virus. The goal of this article was to review some important medicinal plants used in both traditional Chinese and Iranian medicine in treatment of hepatitis. Methods: This manuscript included randomized control experiments, review articles, observational and analytical studies, which have been surveyed in Google Scholar, Scopus, ResearchGate and PubMed by using keywords including hepatitis, medicinal plants, traditional Iranian medicine, traditional Chinese medicine and health benefits. All relevant papers in both English and Chinese language were searched. We screened the articles first by reviewing titles and abstracts and subsequently reading the whole manuscript of those publications deemed suitable. Results: Three main kinds of hepatitis are recognized as hepatitis A, B, and C, and two other types are D and E. Each is caused by a disimilar virus, and all three types generally last for up to 6 months, although types B and C can be chronic, lasting substantially longer. All relevant papers in English language from different countries were collected. The keywords of hepatitis, medicinal plants, traditional Iranian medicine, traditional Chinese medicine and health benefits were searched in Google Scholar, Scopus, Science Direct and PubMed. The most important herbs used to prevent and treatment of different kinds of hepatitis are cordyceps (Cordyceps sinensis), milk thistle (Silybum marianum), licorice root (Glycyrrhiza glabra), and reishi mushroom (Ganoderma lucidum). The most important signs and symptoms of hepatits are flu-like symptoms, abdominal pain, fatigue, jaundice, nausea, loss of appetite and vomiting, weight loss, dark urine, diarrhea, whole body itching, mild anemia, as well as enlarged and tender liver. Conclusion: The use of natural and traditional medicinal plants in the treatments of different hepatitis may provide new solutions and more favorable results in the treatment of viral hepatitis.

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A mini-review of anti-hepatitis B virus activity of medicinal plants

Cited by 22 publications

References 51 publications

In Vitro Calli Production Resulted in Different Profiles of Plant-Derived Medicinal Compounds in Phyllanthus amarus

In Vitro Calli Production Resulted in Different Profiles of Plant-Derived Medicinal Compounds in Phyllanthus amarus

Antiviral Activity of Indonesian Medicinal Plants against Hepatitis B Virus

The Function of some Important TCM and Iranian Medicinal Plants in Treatment of Viral Hepatitis

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