A Mini Overview of Malaria in Pregnancy

Ahmadal-Agroudi, Mahfouz; Megahed, Laila Abd El-Mawla; Abdallah, Elham; Morsy, Tosson A

doi:10.21608/jesp.2017.78027

Cited by 5 publications

(4 citation statements)

References 93 publications

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“…Ahora bien, anualmente, alrededor de 50 millones de mujeres que habitan en regiones endémicas de paludismo, quedan embarazadas, y se estima que 10 mil gestantes y 20 mil niños fallecen producto de su infección durante el embarazo (19,20). En 2019, el 35 % (n = 12 millones) de los 33 millones de embarazos que se reportaron en 33 naciones africanas, con riesgo moderado a grave de transmitir esta enfermedad, estuvo expuesto a infección por malaria durante dichas gestaciones, principalmente en África Central, cuya prevalencia fue del 40 %, seguido de África Occidental, con un 39 %, y África Oriental y del Sur, con un 24 %.…”

Section: Epidemiologíaunclassified

Malaria asociada al embarazo: revisión narrativa

Núñez-Troconis¹,

Ruiz²,

Núñez³

2023

RSOGV

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Malaria infections increase the risk of complications in the mother-fetus binomial. In Venezuela, the casuistry of this vulnerable group has not been updated in recent years. The objective of this narrative review was to comprehensively describe what pregnancy-associated malaria is and its maternal, fetal and neonatal effects; trying to answer the following research question. All forms of pregnancy-associated malaria, including gestational, placental and congenital malaria, cause maternal-fetal and neonatal alterations that, if they progress, could lead to the death of this binomial. Physiopathology and immunopathology can explain the symptoms of pregnant women and the fetus, as well as their complications; depending on the parasitic form affecting. There are new updates in the diagnosis, prevention and treatment of this entity.

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Section: Epidemiologíaunclassified

Malaria asociada al embarazo: revisión narrativa

Núñez-Troconis¹,

Ruiz²,

Núñez³

2023

RSOGV

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“…More than 40% of all births worldwide occur in areas with endemic malaria and in women living in endemic areas, placental malaria occurs in 16-63% of maternal infections [39]. Several histological changes in infected placentae have been described, including the infiltration of mononuclear cells, deposition of malaria pigment, thickening of the trophoblast basement membrane, syncytial knotting, and complement deposition [2,59]. Histologically, placental malaria is characterized by parasites and leukocytes in the intervillous space and pigment within macrophages.…”

Section: Plasmodium and Trypanosomamentioning

confidence: 99%

Stillbirths’ microbiology: a favorable time for post-mortem microbiology

et al. 2023

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Post-Mortem Microbiology (PMM) aims to detect infections that could be a cause of stillbirth. A newborn having no sign of life after delivery is defined as stillbirth. Different infections could cause a chain of events leading to stillbirth but the relationships between maternal infection and stillbirth are often not very clear; as a matter of fact, the positive serologic tests do not prove causality. Screening, prevention, and treatment of maternal infections are important to reduce the stillbirth risk. The identification of an infectious agent that causes stillbirth through PMM is a shared aim by microbiologists, pathologists and surgeons, and it is also the common goal in clinical and forensic autopsies. The aim of this paper is a review the major infections that lead to stillbirths.

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“…18 Annually, around 50 million pregnancies take place in malariaendemic regions, and it is estimated that 10 thousand pregnant women and 20 thousand children perish as a result of their gestational-related infection. 19,20 In 2020, out of the of the 33.8 million pregnancies reported in 33 moderate and high transmission African nations, 34% (n=12 million) were exposed to malarial infection during these pregnancies, mainly in West Africa, with a 39.8% prevalence, followed by Central Africa (39.4%) and East and South Africa (22%). This high prevalence of gestational malaria resulted in 819 thousand newborns with low birthweight, a result of the low use of prenatal care services, with preventive antimalarial treatment during pregnancy.…”

Section: Epidemiologymentioning

confidence: 99%

Malaria and pregnancy: a Venezuelan approach. Review article

Ruiz¹,

Núñez²,

Martín-Castelli³

et al. 2022

OGIJ

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Aim: to review and describe exhaustively the implications of malaria in pregnancy, including its maternal, fetal, and neonatal clinical manifestations and effects; immunopathology and pathophysiology; advancements in its diagnostics, histopathology, and treatment options; and epidemiology, particularly in Venezuela, a country where its data is almost non-existent. Methods: the information used to write this manuscript was obtained during a three-month period, between June and September 2022, from specialized literature, written in English and Spanish, related to malaria associated with pregnancy, mainly published during the last five years, using journals found in the most relevant medical digital archives, including PubMed, SciELO, Elsevier, Google Scholar, Latindex, and Cochrane Plus. Among the keywords used for obtaining this updated information were malaria; malaria in pregnancy; gestational malaria; placental malaria; congenital malaria. Results: all the clinical forms related to malaria in pregnancy, including gestational, placental, and congenital malaria, can cause maternal-fetal alterations, that, in case of progressing, could lead to the death of this binomial. Their pathophysiology and immunopathology can explain the gestational and fetal symptomatology, as well as their complications, depending on the parasite form that affected them. There are new updates regarding the diagnostics, prevention, and treatment of this medical entity. Conclusion: it is imperative to exalt the relevance of studying this disease in pregnant patients, especially in the Venezuelan topography, a focus of infection with a plethora of cases of said entity, whose lack of updated epidemiological data, regarding its prevalence and incidence, is profoundly preoccupying. Pregnant patients are not only one of the most vulnerable risk groups of this parasitosis, but also have the capacity of duplicating the risk of infecting the fetus.

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A Mini Overview of Malaria in Pregnancy

Cited by 5 publications

References 93 publications

Malaria asociada al embarazo: revisión narrativa

Malaria asociada al embarazo: revisión narrativa

Stillbirths’ microbiology: a favorable time for post-mortem microbiology

Malaria and pregnancy: a Venezuelan approach. Review article

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