A mini-epidemic of eruptive hypomelanosis in three children of the same family; the first piece of epidemiological evidence for an infectious cause of a novel paraviral exanthem

Multiple “angiomas” in a 14‐month‐old infant

“…Serological tests were unremarkable. Eruptive pseudoangiomatosis has previously been reported in association with Epstein-Barr virus, cytomegalovirus, ECHO virus and adenovirus infections [3][4][5] . However, as there is no evidence of a virus in the skin, the disease is rather thought to represent an infection-related immune response (paraviral exanthem).…”

“…However, as there is no evidence of a virus in the skin, the disease is rather thought to represent an infection-related immune response (paraviral exanthem). Histologically, ectatic capillaries with prominent endothelial cells and a perivascular lymphohistiocytic infi ltrate are typical but not pathognomonic [ 4,[6][7][8] . Given our patient's typical clinical presentation and age, we decided to do without a biopsy for histological confi rmation.…”

“…This would also explain the familial outbreak previously reported [ 8 ] . Compared to eruptive pseudoangiomatosis, differential diagnoses such as spider nevi, cherry angiomas, as well as multiple lesions of pyogenic granuloma and bacillary angiomatosis do not heal spontaneously and do not present as an exanthem [ 4 ] .…”

Annular Eruptive Pseudoangiomatosis and Adenovirus Infection: A Novel Clinical Variant of Paraviral Exanthems and a Novel Virus Association

“…The inclusion of diseases in this category is debated, but is generally taken to be pityriasis rosea, pityriasis lichenoides, Gianotti-Crosti syndrome, asymmetric periflexural exanthem/unilateral laterothoracic exanthem, papular-purpuric gloves and socks syndrome, EP, and eruptive hypomelanosis (3)(4)(5).…”

“…Antonio CHUH1 , Rüdiger PANZER 2 , Ann-Christine ROSENTHAL2 , Ehrhardt PROKSCH 2 , Werner KEMPF3 , Vijay ZAWAR4 , Helmuth FICKENSCHER5 and Regina FÖLSTER-HOLST 2 1 Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong and the Prince of Wales Hospital, Shatin, Hong Kong, 2 Dermatologie, Venerologie und Allergologie, and 5 Institut für Infektionsmedizin, Christian-Albrechts-Universität zu Kiel und Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Germany, 3 Histologische Diagnostik, and Department of Dermatology, University Hospital Zürich, Zürich, Switzerland, and 4 Department of Dermatology, Godavari Foundation Medical College and Research Center, DUPMCJ, Nashik, India Acta Derm Venereol 2017 Annular eruptive pseudoangiomatosis ml, reference: < 11 U/ml). IgM and IgG against capsid antigens of Epstein-Barr virus, and IgG against its nuclear antigens were negative.…”