A mimicking red blood cell autoantibody accompanying transfusion and alloimmunization

Wenz, Barry; Gurtlinger, Karl F.; Wheaton, David L.; Dugan, E. P.

doi:10.1046/j.1537-2995.1982.22282177123.x

Cited by 12 publications

(5 citation statements)

References 3 publications

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“…This phenomenon has been described for antibodies directed against antigens of the Rhesus system [1,2,5,7], but also against antigens in the S system…”

Section: Introductionmentioning

confidence: 73%

Red-Cell Auto-Antibodies Mimicking Anti-Fy^b Specificity

Veer¹,

Leeuwen²,

Haas³

et al. 1984

Vox Sanguinis

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An antibody is described, produced by an Fy(a+b-) woman that at first reacted with her own cells, preferentially with Fy(b+) cells but not with Fy(a-b-) cells. Later, pure anti-Fyb specificity occurred. Elution and absorption studies revealed that the antibody recognized a determinant absent from Fy(a-b-) cells but present on Fy(a+b-) and Fy(a-b+) cells, much more strongly, however, on the latter, and that it was an autoantibody.

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“…This phenomenon has been described for antibodies directed against antigens of the Rhesus system [1,2,5,7], but also against antigens in the S system…”

Section: Introductionmentioning

confidence: 73%

Red-Cell Auto-Antibodies Mimicking Anti-Fy^b Specificity

Veer¹,

Leeuwen²,

Haas³

et al. 1984

Vox Sanguinis

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“…In each of the previously reported cases the erythrocyte autoantibody developed in association with erythrocyte alloantibodies. Frequently, multiple alloantibodies had already been identified (Orlina et al , 1991; Sosler et al , 1989; Petz & Garratty, 1980; Chaplin & Zarkowksy, 1981; Ambruso et al , 1987), and in some cases the autoantibody occurred simultaneously with the development of new alloantibodies (Lalezari et al , 1975; Wenz et al , 1982). Our data support this observation, since seven of our patients were previously alloimmunized and eight developed one or more new alloantibodies simultaneous with the erythrocyte autoantibody (Table II).…”

Section: Discussionmentioning

confidence: 99%

“…In patients with sickle cell disease there are only a few reports of erythrocyte autoantibody formation. Wenz et al (1982) described a child who, after receiving a single preoperative erythrocyte transfusion, developed an IgG autoantibody with anti-E specificity. The authors did not comment about surface complement or clinical haemolysis.…”

Section: Discussionmentioning

confidence: 99%

“…The development of erythrocyte autoantibodies in association with transfusions is much less commonly recognized. Erythrocyte autoantibodies in transfused patients have been described only in case reports (Orlina et al , 1991; Sosler et al , 1989; Lalezari et al , 1975; Petz & Garratty, 1980; Wenz et al , 1982) or small series (Chaplin & Zarkowksy, 1981; Ambruso et al , 1987). In some of these patients the autoantibodies were associated with clinically significant haemolysis.…”

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confidence: 99%

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Erythrocyte autoantibodies in paediatric patients with sickle cell disease receiving transfusion therapy: frequency, characteristics and significance

et al. 1999

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The formation of erythrocyte autoantibodies following transfusion therapy has been described in case reports and small series. To determine the frequency, serological characteristics, and clinical significance of this phenomenon in paediatric patients with sickle cell disease, we analysed the patient database at the Duke University Pediatric Hematology Clinic. We identified children who received multiple erythrocyte transfusions, then reviewed clinical records to identify children who developed erythrocyte autoantibodies in association with transfusions. Among 184 paediatric patients who received multiple erythrocyte transfusions, 14 children (7.6%) developed warm (IgG) erythrocyte autoantibodies. Median transfusion exposure at the time of autoantibody formation was 24 erythrocyte units, range 3-341 units. The autoantibody reacted as a panagglutinin in 11 cases but had anti-e specificity in three patients. Surface complement also was detected in five patients. Clinically significant haemolysis was documented in four patients, each of whom had both surface IgG and C3 detected. The development of erythrocyte autoantibodies was associated with the presence of erythrocyte alloantibodies. Formation of warm erythrocyte autoantibodies in association with transfusions is not rare in paediatric patients with sickle cell disease. Clinicians should be aware of this complication and recognize that the presence of surface C3 is often associated with significant haemolysis.

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“…96 In 1999, Castellino and associates 97 reported on the frequency, characteristics, and significance of erythrocyte autoantibodies in a large group of multiply transfused children with SCD. 96 In 1999, Castellino and associates 97 reported on the frequency, characteristics, and significance of erythrocyte autoantibodies in a large group of multiply transfused children with SCD.…”

Section: Autoimmunization To Rbc Antigensmentioning

confidence: 99%