A Mimic Molecule of Blue Copper Protein Active Site [(−)-Sparteine-N,N‘](maleonitriledithiolato- S,S‘)copper(II)

Kim, Young‐Jin; Kim, Su-Oak; Kim, Young-Inn; Choi, Sung-Nak

doi:10.1021/ic001396i

Cited by 49 publications

(55 citation statements)

References 28 publications

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“…The decrease in the observed Aʈ value (Axx 15, Ayy 25, Azz 137) is consistent with a severe distortion away from a square planar geometry toward a tetrahedral arrangement of the ligands coordinated to copper. Thus, the EPR data support a type 2 copper site with a N2SO coordination sphere (35) about Cu(II) that is intermediate between a square plane (preferred by Cu(II)) and a tetrahedral configuration (preferred by Cu(I)). We would expect that the coordination about the reduced form of copper would be the tetrahedral structure depicted in Fig.…”

Section: Resultsmentioning

confidence: 67%

Structure of the Alzheimer's Disease Amyloid Precursor Protein Copper Binding Domain

Barnham

McKinstry

Multhaup

et al. 2003

Journal of Biological Chemistry

269

249

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A major source of free radical production in the brain derives from copper. To prevent metal-mediated oxidative stress, cells have evolved complex metal transport systems. The Alzheimer's disease amyloid precursor protein (APP) is a major regulator of neuronal copper homeostasis. APP knockout mice have elevated copper levels in the cerebral cortex, whereas APP-overexpressing transgenic mice have reduced brain copper levels. Importantly, copper binding to APP can greatly reduce amyloid ␤ production in vitro. To understand this interaction at the molecular level we solved the structure of the APP copper binding domain (CuBD) and found that it contains a novel copper binding site that favors Cu(I) coordination. The surface location of this site, structural homology of CuBD to copper chaperones, and the role of APP in neuronal copper homeostasis are consistent with the CuBD acting as a neuronal metallotransporter.

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Section: Resultsmentioning

confidence: 67%

Structure of the Alzheimer's Disease Amyloid Precursor Protein Copper Binding Domain

Barnham

McKinstry

Multhaup

et al. 2003

Journal of Biological Chemistry

269

249

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“…plants has been also studied. [23][24][25][26][27][28] Jirovetz et al 25 characterized the volatile fraction of essential oils from different Piper species by HS-SPME coupled to GC and GC-MS. The results were comparable to those obtained by GC-sniffing and olfactometry.…”

Section: Introductionmentioning

confidence: 99%

Determination of volatile compounds in antioxidant rosemary extracts by multiple headspace solid-phase microextraction and gas chromatography

Carrillo

Tena

2006

Flavour Fragr. J.

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Rosemary extracts are commercialized as natural antioxidants that delay the lipid oxidation process. Residual amounts of rosemary odour-responsible volatile compounds, such as borneol, camphor and verbenone, can remain in the final extract. The presence of these compounds may be undesirable when the extracts are used as food or cosmetic additives. In this paper a MHS-SPME method is proposed to quantify 10 rosemary odour-responsible compounds in a commercial solid rosemary extract. Multiple headspace solid-phase microextraction (MHS-SPME) is a recent technique proposed to eliminate the matrix effect on the quantitative analysis of solid samples. This technique performs few consecutive extractions from the same sample, and the total area corresponding to an exhaustive extraction is calculated as the sum of individual area values obtained from each extraction or by using an equation. The most influential variables of the extraction process, such as type of fibre, temperature and extraction time, were studied. Extraction was carried out using 2.5 mg solid extract and a divinylbenzene-carboxen-polydimethylsiloxane (DVB-CAR-PDMS) fibre at 55°C for 60 min; calibration was carried out using aqueous standard solutions containing 1% (v/v) ethanol at 40°C for 45 min. The features of the method were established using aqueous standard solutions. Precision was 4-15%, expressed as RSD, and the method allowed detection limits of 0.4 -47 ng for p-cymene and verbenone, respectively. Finally, the method was applied to analyse a rosemary solid extract, and verbenone (356 µ µ µ µ µg/g), borneol (190 µ µ µ µ µg/g) and camphor (136 µ µ µ µ µg/g) were found to be the most abundant compounds.

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“…However, where the hetrocyclic atom and the azomethine nitrogen are involved in bidentite coordination, and the sulfur atom is considered not be coordinated, weakly coordinated to the same metal center or coordinated to an adjacent metal center (4) . In (2005) Chandra and co-worker (5) reported the synthesis and charactrisation of 2-methyl cyclohexanon thiosemicarbazone [ …”

Section: Introductionmentioning

confidence: 99%

SYNTHESIS AND CHARACERISATION OF NOVEL PENTADENTATE LIGAND TYPE N2S2O 4-METHYL-2,6- BIS[4-METHYL THIOSEMICARBAZONYLIDEN]- PHENOL AND THEIR COMPLEXES WITH Ni+2 , Pd+2 , Cu+2 , Zn+2 , Cd+2 and Hg+2

Musa¹

2009

JNUS

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A Mimic Molecule of Blue Copper Protein Active Site [(−)-Sparteine-N,N‘](maleonitriledithiolato- S,S‘)copper(II)

Cited by 49 publications

References 28 publications

Structure of the Alzheimer's Disease Amyloid Precursor Protein Copper Binding Domain

Structure of the Alzheimer's Disease Amyloid Precursor Protein Copper Binding Domain

Determination of volatile compounds in antioxidant rosemary extracts by multiple headspace solid-phase microextraction and gas chromatography

SYNTHESIS AND CHARACERISATION OF NOVEL PENTADENTATE LIGAND TYPE N2S2O 4-METHYL-2,6- BIS[4-METHYL THIOSEMICARBAZONYLIDEN]- PHENOL AND THEIR COMPLEXES WITH Ni+2 , Pd+2 , Cu+2 , Zn+2 , Cd+2 and Hg+2

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