A Mild and Highly Efficient Oxidation of Sulfides to Sulfoxides with Periodic Acid Catalyzed by FeCl₃

Abstract

H i g h l y E f f i c i e n t O x i d a t i o n o f S u l f i d e s t o S u l f o x i d e s

Relative Inhibitory Potency of Molinate and Metabolites with Aldehyde Dehydrogenase 2: Implications for the Mechanism of Enzyme Inhibition

“…Adapted from a literature method (30), molinate (112.7mg, 0.6mmol) was combined with iron trichloride (FeCl 3 , 3mg, 0.02mmol) in 600µL of acetonitrile (ACN) and vigorously vortexed for 5min. Then, periodic acid (150mg, 0.66mmol) was added.…”

Iron-Catalyzed Reactions in Organic Synthesis

“…Selective oxidations of sulfides to sulfoxides with iron catalysts and H 5 IO 6 or HNO 3 as oxidants have been reported, and they offer interesting alternatives to existing methods . However, to effect this reaction with iron catalysts in an asymmetric fashion has always been a major challenge.…”

Some applications of zirconium(IV) tetrachloride (ZrCl4) and zirconium(IV) oxydichloride octahydrate (ZrOCl2.8H2O) as catalysts or reagents in organic synthesis

“…This transformation has been accomplished in a variety of ways [16][17][18][19][20][21][22][23][24][25][26][27][28]. During recent years, very useful procedures involving aqueous hydrogen peroxide (H 2 O 2 ) as the terminal oxidant, and a Lewis acid as an activator have been developed to promote this transformation [29], Very recently, H 2 O 2 /ZrCl 4 system has been applied as a selective method to oxidize sulfides efficiently to their sulfoxides or sulfones even in the presence of easily oxidized functional groups (Scheme 8) [30].…”