A mild and efficient synthesis of benzodiazepines using La(NO3)3· 6H2O as a catalyst under solvent-free conditions

Silica gel‐supported sulfuric acid catalyzed synthesis of 1,5‐benzodiazepine derivatives

“…The organic layer was concentrated, and the crude product was purified by silica gel column chromatography using ethyl acetate-n-hexane (1:9) as eluent to afford the desired product (3). Entry 1-5 and 11 spectral data [20], entry 7, 8 spectral data [21], and entry 9, 10, and 13 spectral data [22] are in full agreement with the reported literature, and the new compounds spectral data are given later.…”

Lanthanum(III) nitrate hexahydrate catalyzed chemoselective thioacetalization of aldehydes

“…They can be conveniently handled and removed from the reaction mixture, making the experimental procedure simple and eco-friendly. Recently, we explored La(NO 3 ) 3 ·6H 2 O as a mild and efficient acid catalyst in various organic transformations, such as chemoselective deprotection of primary acetonides [28], tetrahydropyranylation of primary alcohols [29], acetylation of alcohols, phenols and amines [30], in the synthesis of α-amino nitriles [31], benzodiazepines [32] and N -tert-butoxycarbonylation, N-benzyloxycarbonylation of amines [33,34]. La(NO 3 ) 3 ·6H 2 O is mild, inexpensive, nontoxic, readily available, easy to handle and insensitive to air.…”

Synthesis of 2-Substituted Benzimidazoles and 1,5- Disubstituted Benzodiazepines Using Alum

“…[12][13][14][15][16][17][18] However, to the best of our knowledge no attempt has been made to correlate the surface properties of the catalysts and their catalytic activity in the condensation of aldehydes/ketones with OPDA to synthesizes benzimidazole and benzodiazepines Metal oxides and supported metal oxides are known to possess surface acidity and/or basicity and activate a number of industrially important organic transformations. [19][20][21][22][23][24] We have developed new method of synthesis of benzimidazole using green approach and alum as catalyst.…”