A microscopic oxygen transport model for ultra‐high dose rate radiotherapy in vivo: The impact of physiological conditions on FLASH effect
Lixiang Guo,
Paul M. Medin,
Ken Kang‐Hsin Wang
Abstract:BackgroundUltra‐high dose rate irradiation (≥40 Gy/s, FLASH) has been shown to reduce normal tissue toxicity, while maintaining tumor control compared to conventional dose‐rate radiotherapy. The radiolytic oxygen (O2) depletion (ROD) resulting from FLASH has been proposed to explain the normal tissue protection effect; however, in vivo experiments have not confirmed that FLASH induced global tissue hypoxia. Nonetheless, the experiments reported are based on volume‐averaged measurement, which have inherent limi… Show more
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