A microscopic comparison of clinically and artificially produced changes in enamel

Coolidge, Thomas B.; Besic, F.C.; Jacobs, M.H.

doi:10.1016/0030-4220(55)90384-4

Cited by 34 publications

(6 citation statements)

References 5 publications

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“…Among the various methods for in vitro simulation of sub-surface enamel lesions, perhaps the simplest involves applying plain acetate or Iactate buffers partially saturated with calcium and phosphate to enamel surfaces as proposed by earlier investigators (Enright & Friesell 1933, Coolidge et al, 1955, Manson-Hing et al, 1972, While partially saturated buffers of high solvent activity tend to produce either surface erosion or very superficial subsurface lesions in short periods of time, those of lower solvent activities over long periods of time produce subsurface lesions with a preserved surface layer of considerable thickness (10-30 ^m). Under the conditions of this investigation the apparent width of a 5-day lesion was approximately 70-90 ^m with a preserved layer of about lOjtm, Because of the free diffusion of ions in the acid bufTer, all areas of the enamel surface are under comparable acid attack.…”

Section: Natural Vs Experimental Conditions For Inducing Lesions On Dmentioning

confidence: 99%

Enamel remineralization as a factor in the pathogenesis of dental caries

Koulourides¹,

Cameron²

1980

J Oral Pathology Medicine

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This paper describes an investigation of local tooth resistance acquired in response to cariogenic attacks and remineralization periods from environmental fluids. Surfaees from extracted human teeth with yellow and brown areas indicative of consolidated carious lesions were exposed to acid buffers. Subsurface lesions were developed on areas of sound enamel adjaeent to, but not in areas of. consolidated lesions. The development of higher tooth resistance to acid through demineralization and remineralization was demonstrated experimentally on bovine enamel presoftened in acid, treated with fluoride, exposed to the oral environtnent, and finally exposed to acid buffers for development of subsurfaee lesions. These results are interpreted as an extension of the theory of tissue adaptation to an injurious challenge, in that the tooth surfaee is primed by the ehallenge for possible remineralization and the development of higher resistance. Thus, cariogenic challenges ean result in either local adaptation of the enamel to the challenge through lesion eonsolidation or to open eavitation. As in any biologieal adaptation, the determining faetors for the final outcome are: (a) the frequency and duration of the challenge, (b) the frequency and duration of remineralizing eonditions. and (c) the composition of the remineralizing fluid. The implications of the theory in the pathogenesis of caries are discussed in the light of clinical and laboratory investigations.

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Section: Natural Vs Experimental Conditions For Inducing Lesions On Dmentioning

confidence: 99%

Enamel remineralization as a factor in the pathogenesis of dental caries

Koulourides¹,

Cameron²

1980

J Oral Pathology Medicine

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“…Besic [1953] and Coolidge [1955] were the first to investigate the influence of cal cium, phosphate, and acid concentration on the lesion formation. In previous stud ies we determined the mineral content in such artificial lesions as a function of depth [Theuns el al., 1983a-c].…”

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confidence: 99%

The Surface Layer during Artificial Carious Lesion Formation

Theuns¹,

Dijk²,

Driessens

et al. 1984

Caries Res

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This paper gives a detailed description of the development of the surface layer during demineralization of human enamel. Optical inspection of microradiograms of lesions in different stages of development can give the impression that the surface layer increases in thickness with time. Using a more objective method of inspection together with an explicit description, the development of the surface layer was followed with time more quantitatively. This method was based on the changes occurring at the inside of the surface layer. It appeared that the surface layer thickness was constant with time in all lesions investigated. These observations indicate that at constant composition of the buffer solutions, no dissolved material from the body of the lesion is deposited at the inside of the surface layer.

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“…Artificially induced WSLs were used to study the remineralization of enamel owing to their histological similarity to natural WSLs. 29,30 The method of production of WSLs was verified by subjecting 10 additional premolars to the demineralizing solution for 96 hours followed by sectioning of the teeth and examination of the sections using PLM. All the sections showed subsurface enamel lesions.…”

Section: Discussionmentioning

confidence: 99%

Effect of nano-hydroxyapatite versus caesin-phosphopeptide amorphous calcium phosphate on remineralization of early enamel lesions - In vitro study

Yacout

Mowafy

Abdallah

2020

Egyptian Orthodontic Journal

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Objective: To evaluate and compare the effect of zinc carbonate -nano hydroxyapatite (n-HA) (Biorepair toothpaste) and casein phosphopeptide -amorphous calcium phosphate (CPP-ACP) (GC Tooth Mousse creme) on the depth of white spot lesions (WSLs). Materials and Methods: Thirty six human premolar teeth with artificially induced WSLs were randomly assigned to three groups (n=12). Group I: n-HA toothpaste, Group II: CPP-ACP topical creme, and Group III: negative control. The teeth were longitudinally sectioned and photographed using polarized light microscopy (PLM) and the depth of enamel subsurface demineralization was measured. Statistical analysis was performed. Results: The n-HA group showed the least mean lesion depth, followed by the CPP-ACP group (76.8 ± 10.2 µm and 79.8 ± 9.7 µm respectively), while, the control group showed the largest mean lesion depth (107.8 ± 8.5 µm).

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A microscopic comparison of clinically and artificially produced changes in enamel

Cited by 34 publications

References 5 publications

Enamel remineralization as a factor in the pathogenesis of dental caries

Enamel remineralization as a factor in the pathogenesis of dental caries

The Surface Layer during Artificial Carious Lesion Formation

Effect of nano-hydroxyapatite versus caesin-phosphopeptide amorphous calcium phosphate on remineralization of early enamel lesions - In vitro study

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