A microRNA profile associated with Opisthorchis viverrini-induced cholangiocarcinoma in tissue and plasma

Plieskatt, Jordan; Rinaldi, Gabriel; Feng, Yanjun; Peng, Jin; Easley, Samantha; Jia, Xinying; Potriquet, Jeremy; Pairojkul, Chawalit; Bhudhisawasdi, Vajarabhongsa; Sripa, Banchob; Brindley, Paul J.; Bethony, Jeffrey M.; Mulvenna, Jason

doi:10.1186/s12885-015-1270-5

Cited by 38 publications

(34 citation statements)

References 72 publications

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“…123,165 Although many studies have validated gene expression signatures associated with patient outcomes, the clinical significance of microRNA signatures is not yet clear due to the limited number of large comprehensive profiling studies. 119,[166][167][168] Mutations in oncogenes such as KRAS and BRAF can be used to determine prognosis for patients with pancreatic or colorectal cancers. [169][170][171] However, there is controversy over whether these mutations can predict outcomes of patients with iCCA.…”

Section: Molecular Markers Of Iccamentioning

confidence: 99%

Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis

et al. 2017

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Primary liver cancer is the second leading cause of cancer-related death worldwide and therefore a major public health challenge. We review hypotheses of the cell of origin of liver tumorigenesis and clarify the classes of liver cancer based on molecular features and how they affect patient prognosis. Primary liver cancer comprises hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (iCCA), and other rare tumors, notably fibrolamellar carcinoma and hepatoblastoma. The molecular and clinical features of HCC versus iCCA are distinct, but these conditions have overlapping risk factors and pathways of oncogenesis. A better understanding of the cell types originating liver cancer can aid in exploring molecular mechanisms of carcinogenesis and therapeutic options. Molecular studies have identified adult hepatocytes as the cell of origin. These cells have been proposed to transform directly into HCC cells (via a sequence of genetic alterations), to dedifferentiate into hepatocyte precursor cells (which then become HCC cells that express progenitor cell markers), or to transdifferentiate into biliary-like cells (which give rise to iCCA). Alternatively, progenitor cells also give rise to HCCs and iCCAs with markers of progenitor cells. Advances in genome profiling and next-generation sequencing have led to the classification of HCCs based on molecular features and assigned them to categories such as proliferation-progenitor, proliferation-transforming growth factor β, and Wnt-catenin β1. iCCAs have been assigned to categories of proliferation and inflammation. Overall, proliferation subclasses are associated with a more aggressive phenotype and poor outcome of patients, although more specific signatures have refined our prognostic abilities. Analyses of genetic alterations have identified those that might be targeted therapeutically, such as fusions in the FGFR2 gene and mutations in genes encoding isocitrate dehydrogenases (in approximately 60% of iCCAs) or amplifications at 11q13 and 6p21 (in approximately 15% of HCCs). Further studies of these alterations are needed before they can be used as biomarkers in clinical decision making.

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Section: Molecular Markers Of Iccamentioning

confidence: 99%

Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis

et al. 2017

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“…Indeed, it is now apparent that merging different miRs into a panel of biomarkers can offer greater sensitivity and specificity. For instance, an miR profile of eight plasma miRs (483‐5p, 505‐3p, 874, 885‐5p, 320b, 92b‐3p, 1275, 1307‐3p) was shown to associate with iCCA, regardless of the degree of tumour differentiation . The levels of miR‐192 were also shown to be increased in serum from patients with O viverrini ‐related CCA compared with healthy controls (AUC: 0.803; sensitivity: 74%; specificity: 71%), positively correlating with lymph node metastasis and poor survival .…”

Section: Non‐invasive Biomarkersmentioning

confidence: 99%

Diagnostic and prognostic biomarkers in cholangiocarcinoma

Macı́as

Kornek

Rodrigues

et al. 2019

Liver International

101

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The high mortality rate of cholangiocarcinoma (CCA) is due, in part, to the lack of non‐invasive approaches able to accurately detect this silent tumour at early stages, when therapeutic options can be potentially curative or may at least increase the overall survival of patients. The fact that the majority of CCA tumours are not linked to any known aetiological factor highly compromises the monitoring of patients at risk for tumour development and also their early diagnosis. Combination of clinical/biochemical features, imaging techniques and analysis of non‐specific tumour biomarkers in serum are commonly used to help in the diagnosis of CCA, but tumour biopsy is usually required to confirm the diagnosis. Moreover, no prognostic biomarkers are currently used in the clinical setting, deserving more innovative research, and international validation and consensus. Important efforts have been made in the last few years to identify accurate non‐invasive biomarkers, by using innovative techniques and high‐throughput omics technologies. This review summarizes and discusses the advances in the investigation of novel diagnostic and prognostic biomarkers in CCA and envisions the future directions in this field of research.

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“…In addition to Opisthorchis infestation, studies have also linked Clonorchis infestation with cholangiocarcinoma [ 32 , 35 – 40 ]. Liver fluke induced chronic inflammation coupled with some specific microRNAs may explain the carcinogenesis from Opisthorchis or Clonorchis infection [ 41 , 42 ].…”

Section: Panel 2: Review On the Link Between Sanitation And Ncdsmentioning

confidence: 99%

Sanitation for all: the global opportunity to increase transgenerational health gains and better understand the link between NCDs and NTDs, a scoping review

Mishra

Dhimal

Bhandari

et al. 2017

Trop Dis Travel Med Vaccines

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The global sanitation divide is narrowing. However, in many countries in Asia and Africa, the gap between rural and urban sanitation coverage is rather widening. Moreover, there is an increase in the burden of non-communicable diseases (NCDs), notwithstanding to the already high burden of neglected tropical diseases (NTDs). A scientific query is building on how the global ‘sanitation for all’ goal will address the dual burden of NTDs and NCDs, and help further understand the link between the two. This paper aims to discuss the link between i) sanitation and NTDs, and ii) sanitation and NCDs through a scoping review of the literature.

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A microRNA profile associated with Opisthorchis viverrini-induced cholangiocarcinoma in tissue and plasma

Cited by 38 publications

References 72 publications

Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis

Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis

Diagnostic and prognostic biomarkers in cholangiocarcinoma

Sanitation for all: the global opportunity to increase transgenerational health gains and better understand the link between NCDs and NTDs, a scoping review

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