A microporous titanosilicate for selective killing of HeLa cancer cells

Ferdov, Stanislav; Shikova, Evelina; Ivanova, Zina; Dimowa, L.; Nikolova, Rositsa; Lin, Zhi; Shivachev, Boris

doi:10.1039/c3ra23381b

Cited by 11 publications

(5 citation statements)

References 29 publications

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“…204,218 The anticancer drugs were loaded into the pores of zeolite Y (FAU), zeolite A (LTA) and zeolite Beta (BEA), and they have shown a noticeable cytotoxic effect when applied to cancer cells. 204,219 However, the zeolites alone reveal no toxicity to cancer cells, while, importantly, anticancer drug-zeolite led to an inhibition of cell viability up to 585-fold when compared to the non-encapsulated drug.…”

Section: Drug Delivery Application Of Nanosized Zeolitesmentioning

confidence: 99%

Nanosized microporous crystals: emerging applications

2015

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This review highlights recent developments in the synthesis and unconventional applications of nanosized microporous crystals including framework (zeolites) and layered (clays) type materials. Owing to their microporous nature nanosized zeolites and clays exhibit novel properties, different from those of bulk materials. The factors controlling the formation of nanosized microporous crystals are first revised. The most promising approaches from the viewpoint of large-scale production of nanosized zeolites and clays are discussed in depth. The preparation and advanced applications of nanosized zeolites and clays in free (suspension and powder forms) and fixed (films) forms are summarized. Further the review emphasises the non-conventional applications of new porous materials. A comprehensive analysis of the emerging applications of microporous nanosized crystals in the field of semiconductor industry, optical materials, chemical sensors, medicine, cosmetics, and food industry is presented. Finally, the future needs and perspectives of nanosized microporous materials (zeolites and clays) are addressed.

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Section: Drug Delivery Application Of Nanosized Zeolitesmentioning

confidence: 99%

Nanosized microporous crystals: emerging applications

2015

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“…[1,2,[4][5][6][7][8] This phenomenon is known as polyamorphism [9,10] and is well-documented for tetrahedral microporous aluminosilicates, namely zeolites. [14] As a prominent member of that family, ETS-4 is a microporous titanosilicate that is known for its anticancer properties [15] and size-adjustable pores for gas separation. [2] Similar to zeolites, transition-metal silicates show porous-network topologies, but instead of consisting of AlO 4 tetrahedra, the building blocks of the SiO 4 units are combined with MO x polyhedra of various elements.…”

Section: Stanislav Ferdov*mentioning

confidence: 99%

“…[1,[11][12][13] Polyamorphism in zeolites involves a low-density amorphous phase, which defines the onset of the structural collapse, and a high-density amorphous phase that forms later on further heating. [14] As a prominent member of that family, ETS-4 is a microporous titanosilicate that is known for its anticancer properties [15] and size-adjustable pores for gas separation. [14] As a prominent member of that family, ETS-4 is a microporous titanosilicate that is known for its anticancer properties [15] and size-adjustable pores for gas separation.…”

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confidence: 99%

Low‐Density Macroporous Foams Obtained from a Molecular Sieve by Temperature‐Induced Amorphization

Ferdov

2013

Angew Chem Int Ed

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The thermal properties of zeolites and related porous solids are essential for their applications. It is currently thought that crystalline porous materials collapse to a dense amorphous state when subjected to temperatures above their thermal stability. [1,2] Herein, an alternative route of amorphization for ordered molecular sieves is revealed that leads to light, template-free, and hierarchical macroporous foams. Simple control of the time and temperature in an ambient atmosphere ensures thermal decomposition and drastic expansion of the microporous titanosilicate ETS-4 (Engelhard titanosilicate 4), [3] which results in progressively low-density (0.73-0.17 g cm À3 ) multichamber bodies with pore sizes that range from less than one to several hundred micrometers. The formation of macroporous foams by thermal disintegration of crystalline microporous solids could be an ideal system for a better understanding of the amorphization phenomenon observed in molecular sieves, and offers a wide range of applications in the context of inorganic porous materials.Porous crystalline materials comprise a large number of solids that are composed of condensed units of various elements. At elevated temperatures, their low-density frameworks compressively collapse to a glass with conventional density.[1] For a number of materials, this process of thermal amorphization is related to the co-existence of at least two amorphous phases with the same composition, but with different densities. [1,2,[4][5][6][7][8] This phenomenon is known as polyamorphism [9,10] and is well-documented for tetrahedral microporous aluminosilicates, namely zeolites. [1,[11][12][13] Polyamorphism in zeolites involves a low-density amorphous phase, which defines the onset of the structural collapse, and a high-density amorphous phase that forms later on further heating. [2] Similar to zeolites, transition-metal silicates show porous-network topologies, but instead of consisting of AlO 4 tetrahedra, the building blocks of the SiO 4 units are combined with MO x polyhedra of various elements. [14] As a prominent member of that family, ETS-4 is a microporous titanosilicate that is known for its anticancer properties [15] and size-adjustable pores for gas separation. [16] The thermal behavior of ETS-4 has been studied profoundly, [16][17][18][19] and although the material has been known since the late 1980s, [3] nothing unusual about its amorphous state is reported. The structure starts to collapse at 200 8C, and it becomes completely amorphous at 500 8C. At higher temperatures (700-800 8C), the amorphous fraction transforms into a dense titanosilicate with narsarsukite structure. [18,20] Herein, we show how the thermal disintegration of ETS-4 reveals a route of amorphization that leads to macroporous structures with progressively expandable pores and low-density frameworks.Macroporous titanosilicate foams were prepared by a onestep method. ETS-4 particles were gradually heated and cooled in air (for details, see the Experimental Section). The structural disinte...

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“…Besides zeolites, which consist in tetrahedra, a few microporous inorganic materials with mixed polyhedral frameworks exist in nature, , for example, umbite. Encouraged by these natural products, the development of new microporous silicates with mixed tetrahedral–octahedral frameworks, such as titanosilicates and zirconosilicate, catches much attention and has broadened the family of zeolite-type materials and the possibility of applications. − For example, the first inorganic drug (Lokelma) for treating hyperkalemia was approved recently, , which is a zirconium silicate (ZS-9). Potassium is asymmetrically distributed under physiological conditions, namely, ca.…”

Section: Introductionmentioning

confidence: 99%

Syntheses of Hafnium–Zirconium Silicate Solid Solutions and a Simple Method to Efficiently Evaluate the Homogeneity of Zr and Hf Distribution

Lin

2021

J. Phys. Chem. C

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Solid solutions of the microporous mixed tetrahedra− octahedra framework with the structures AV-3 Na 2+z [(Zr 1−x Hf x )-Si 3 O 9 (Cl,OH) z ]•H 2 O (x = 0, 0.33, 0.67, and 1), AV-13 Na 2+z [(Zr 1−x Hf x )Si 3 O 9 Cl z ]•2.5H 2 O (x = 0, 0.33, and 1), and AV-14 Na 2 [(Zr 1−x Hf x )Si 4 O 11 ]•2H 2 O (x = 0, 0.33, and 1) have been prepared under hydrothermal conditions. This was the first time that the hydrothermal synthesis of Hf-AV-3 was reported. Wadeite K 2 [(Zr 1−x Hf x )Si 3 O 9 ] (x = 0, 0.33, 0.67, and 1) has been prepared using high-temperature phase transformation. The desired phase and phase purity were studied by powder X-ray diffraction, scanning electron microscopy, and energy dispersive X-ray spectrometry. The framework substitution of Zr by Hf has been investigated by 29 Si magic-angle spinning (MAS) nuclear magnetic resonance (NMR) and Raman spectroscopy. In the selected region, Raman shifts depend on the hafnium content in these samples. 29 Si MAS NMR is a unique technique, which provides clear evidence for the framework substitution of Zr by Hf. Therefore, the hafnium content is able to be estimated from Raman shifts of bands in the selected region and the intensity of the 29 Si MAS NMR signals. 29 Si MAS NMR spectroscopy is also proposed to be an efficient technique to evaluate the homogeneity of Zr and Hf distribution in the hafnium−zirconium silicate solid solution.

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A microporous titanosilicate for selective killing of HeLa cancer cells

Abstract: Structural distribution of zinc(II) ions in the pore system of three silicate molecular sieves has revealed an unprecedented application of the microporous titanosilicate Zn ETS 4 as a non toxic, highly efficient and selective inhibitor of HeLa cancer cells.

Cited by 11 publications

References 29 publications

Nanosized microporous crystals: emerging applications

Nanosized microporous crystals: emerging applications

Low‐Density Macroporous Foams Obtained from a Molecular Sieve by Temperature‐Induced Amorphization

Syntheses of Hafnium–Zirconium Silicate Solid Solutions and a Simple Method to Efficiently Evaluate the Homogeneity of Zr and Hf Distribution

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