A microphysiological model of human trophoblast invasion during implantation

Park, Ju Young; Mani, Subha; Clair, Gérémy; Olson, Heather; Paurus, Vanessa; Ansong, Charles; Blundell, Cassidy; Young, Rachel E.; Kanter, Jessica R.; Gordon, Scott M.; Yi, Alex Y.; Mainigi, Monica; Huh, Dongeun

doi:10.1038/s41467-022-28663-4

Cited by 51 publications

(55 citation statements)

References 69 publications

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“…Other potential players during uterine spiral artery remodeling are immune cells (macrophages and dNK cells), especially dNK cells are present in high numbers within the decidua, and are suggested to be responsible for the disruption of endothelial structures [ 28 , 65 , 170 ]. A very novel organ-on-a-chip model supports a general promoting role of dNK cells on EVT invasion [ 149 ].…”

Section: Extravillous Trophoblast Subpopulations and Trophoblast Inva...mentioning

confidence: 99%

Early human trophoblast development: from morphology to function

Gauster

Moser

Wernitznig

et al. 2022

Cell. Mol. Life Sci.

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Human pregnancy depends on the proper development of the embryo prior to implantation and the implantation of the embryo into the uterine wall. During the pre-implantation phase, formation of the morula is followed by internalization of blastomeres that differentiate into the pluripotent inner cell mass lineage, while the cells on the surface undergo polarization and differentiate into the trophectoderm of the blastocyst. The trophectoderm mediates apposition and adhesion of the blastocyst to the uterine epithelium. These processes lead to a stable contact between embryonic and maternal tissues, resulting in the formation of a new organ, the placenta. During implantation, the trophectoderm cells start to differentiate and form the basis for multiple specialized trophoblast subpopulations, all of which fulfilling specific key functions in placentation. They either differentiate into polar cells serving typical epithelial functions, or into apolar invasive cells that adapt the uterine wall to progressing pregnancy. The composition of these trophoblast subpopulations is crucial for human placenta development and alterations are suggested to result in placenta-associated pregnancy pathologies. This review article focuses on what is known about very early processes in human reproduction and emphasizes on morphological and functional aspects of early trophoblast differentiation and subpopulations.

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Section: Extravillous Trophoblast Subpopulations and Trophoblast Inva...mentioning

confidence: 99%

Early human trophoblast development: from morphology to function

Gauster

Moser

Wernitznig

et al. 2022

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

show abstract

“…Future developments include 3D-models containing both stromal, vascular, immune and epithelial cells. For example, a new 'implantation-on-a-chip model that includes maternal preimplantation immune cells shows that these affect the decidua of pregnancy [67]. Additional new models that enable study of the interactions between all cell types involved at implantation are eagerly awaited.…”

Section: Organoidsmentioning

confidence: 99%

Infertility and the Endometrium

Salamonsen¹,

Dimitriadis²

2022

Clin. Exp. Obstet. Gynecol.

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Background: A couple's infertility can originate from the male and/or the female. In women, the uterus provides the site where the maternal-fetal interface is established and maintained. Final blastocyst development occurs within the uterine cavity, then the blastocyst must attach to and implant into the endometrium (the inner uterine surface), via its outermost trophectodermal cells. Beneath the epithelium, these differentiate into syncytial trophoblast and invasive trophoblast -the latter progress through the endometrium to invade the spiral arteries converting them to the flaccid blood sacs of the placenta. Therefore, the endometrium plays a critical role in establishment of pregnancy. Objectives: To critically examine current knowledge of endometrial preparation for blastocyst implantation and placental development at the cellular and molecular level and to evaluate measures to improve implantation success. Mechanism: Literature searching by leading experts in the field. Findings: A wealth of new knowledge resulting from 'omics' technologies and new functional models has greatly enhanced our knowledge, but this information is yet to be translated into enhanced outcomes. Conclusions: The endometrium remains the 'black box' of infertility. Extensive trials do not support current adjuvant therapies as being better than placebo while effectively timed testing for endometrial preparedness for implantation is still urgently needed.

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“…Hydrogels are ductile and extremely porous polymers with a three-dimensional network structure, which was first produced by Wicherle and Lim in 1960 [ 3 ]. Over time, the research of hydrogels has developed for biomedical applications [ 4 ], including wound dressings [ 5 , 6 ], anti-tumor immunotherapy [ 7 , 8 ], anti-central nervous system disorders [ 9 ], tissue-engineering [ 10 , 11 , 12 , 13 , 14 ], smart drug-delivery systems [ 7 , 15 , 16 ], and contraception [ 15 ], due to their good biocompatibility, excellent physical and mechanical properties, and long-term implant stability.…”

Section: Introductionmentioning

confidence: 99%

Advances in Cellulose-Based Hydrogels for Biomedical Engineering: A Review Summary

Zou¹,

Yao²,

Cui³

et al. 2022

Gels

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In recent years, hydrogel-based research in biomedical engineering has attracted more attention. Cellulose-based hydrogels have become a research hotspot in the field of functional materials because of their outstanding characteristics such as excellent flexibility, stimulus-response, biocompatibility, and degradability. In addition, cellulose-based hydrogel materials exhibit excellent mechanical properties and designable functions through different preparation methods and structure designs, demonstrating huge development potential. In this review, we have systematically summarized sources and types of cellulose and the formation mechanism of the hydrogel. We have reviewed and discussed the recent progress in the development of cellulose-based hydrogels and introduced their applications such as ionic conduction, thermal insulation, and drug delivery. Also, we analyzed and highlighted the trends and opportunities for the further development of cellulose-based hydrogels as emerging materials in the future.

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A microphysiological model of human trophoblast invasion during implantation

Cited by 51 publications

References 69 publications

Early human trophoblast development: from morphology to function

Early human trophoblast development: from morphology to function

Infertility and the Endometrium

Advances in Cellulose-Based Hydrogels for Biomedical Engineering: A Review Summary

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